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Malignant melanoma of the gallbladder: A case report and literature review

Jeon HJ, Kwon HJ, Kim SG, Hwang YJ

Metastatic melanoma of the gallbladder is extremely rare. It has a poor prognosis. Its optimal treatment remains unclear. Surgical resection is generally considered the mainstay of treatment. However, there are...
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A Case of Blue Nevus of the Nasal Septum

Choi JY, Choi MS

Blue nevus (BN) is a blue- or black-colored benign melanocytic proliferation that commonly occurs on the dorsal surface of the hands and feet or in the head and neck region....
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Salicylamide Enhances Melanin Synthesis in B16F1 Melanoma Cells

Ito Y, Sato K

Salicylamide, a non-steroidal anti-inflammatory drug (NSAID), is used as an analgesic and antipyretic agent. We have previously shown that several NSAIDs have anti-melanogenic properties in B16F1 melanoma cells. In contrast,...
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Differential Sensitivity of Wild-Type and BRAF-Mutated Cells to Combined BRAF and Autophagy Inhibition

Yeom H, Hwang SH, Han BI, Lee M

BRAF inhibitors are insufficient monotherapies for BRAF-mutated cancer; therefore, we investigated which inhibitory pathway would yield the most effective therapeutic approach when targeted in combination with BRAF inhibition. The oncogenic...
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Vertical Rectus Abdominis Myocutaneous-Pedicled Island Flap for Covering Defect of the Suprapubic Area: A Case Report

Yeo HD, Chung JH, Park SH, Lee BI, Yoon ES

Immediate reconstruction of defects in the lower abdomen is challenging. We present a successful reconstruction case using a vertical rectus abdominis myocutaneous (VRAM) flap for a radiation ulcer on the...
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Frequency of Trauma, Physical Stress, and Occupation in Acral Melanoma: Analysis of 313 Acral Melanoma Patients in Korea

Lee JH, Choi YD, Hwang JH, Shin MH, Yun SJ

Background: Traumatic events are thought to be a cause of acral melanoma. However, little is known about the role of mechanical trauma or physical stress in the development of acral...
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Analysis of the Dermatologic Side Effects and the Factors Affecting the Efficacy of Immune Checkpoint Inhibitor in Melanoma: A Single-Center, Retrospective Study

Yoon D, Oh SJ, Kim HJ, Park JH, Lee JH, Lee DY, Lee JH

  • KMID: 2516137
  • Korean J Dermatol.
  • 2021 May;59(4):251-258.
Background: Programmed death 1 inhibitors enhance pre-existing immune responses by directly blocking anti-programmed cell death receptor-1. They have been widely used these days, but little is known about the dermatologic...
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Primary malignant mucosal melanoma of the maxillofacial area

Kim H, Lee S, Cha IH, Kim HJ, Nam W

Objectives: We aimed to collect and report data from all patients who have been diagnosed with mucosal malignant melanoma to obtain the epidemiology and principles of current treatments. Materials and Methods:...
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Predictor of Subungual Melanoma against Benign Longitudinal Melanonychia: A Retrospective Cohort Study from Korea

Yim SH, Kwon IS, Hong D, Jung KE, Lee Y, Seo YJ, Choi CW

Background: Longitudinal melanonychia (LM) is a common clinical finding. Most cases of LM are benign, and a waitand-see approach is preferred in the management of this condition. Nevertheless, it is...
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Development of GATE Monte Carlo Code for Simulation and Dosimetry of New I-125 Seeds in Eye Plaque Brachytherapy

Taherparvar P, Fardi Z

Purpose Dose distributions are calculated by Monte Carlo (MC) simulations for two low-energy models 125 I brachytherapy source—IrSeed-125 and IsoAid Advantage (model IAI-125A)—loaded in the 14-mm standardized plaque of the...
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A Case of Metastatic Melanoma in the Liver Mimicking Hepatocellular Carcinoma

So JK, Hong JY, Chung MW, Cho SB

The liver is one of the most common sites of metastasis. Although most metastatic liver cancers are hypovascular, some hypervascular metastases, such as those from melanoma, need to be differentiated...
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Elucidating molecular mechanisms of acquired resistance to BRAF inhibitors in melanoma using a microfluidic device and deep sequencing

Han J, Jung Y, Jun Y, Park S, Lee S

BRAF inhibitors (e.g., vemurafenib) are widely used to treat metastatic melanoma with the BRAF V600E mutation. The initial response is often dramatic, but treatment resistance leads to disease progression in...
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Systemic therapy augmented by radiotherapy (STAR) effect for brain metastases in a BRAF-mutated melanoma patient with prolonged survival: a case report

Cristaudo A, Malorgio A, Medoro S, Stefanelli A

Brain metastases are common in stage IV malignant melanoma, carrying a prognosis traditionally regarded as severe, with a median survival of few months. Recently introduced systemic therapies as targeted therapy...
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Subunit Principle: Key Element for Plantar Reconstruction with Free Sensate Flaps

Sanchez BYA, Gallardo DDL, Espinoza JAG, Soto DF

Purpose: Plantar wounds represent a frequent practice of the plastic and reconstructive surgeon. The uniqueness and high complexity of the microarchitecture and biomechanics of the plantar region explain the complex...
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Malignant Melanoma of Anorectum: Two Case Reports

Pham BV, Kang JH, Phan HH, Cho MS, Kim NK

Malignant melanoma of the anorectum is a rare disorder. Patients often present with local symptoms similar to benign diseases. The prognosis is very poor, and almost all patients die because...
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PTEN Promoter Hypermethylation Is Associated with Breslow Thickness in Acral Melanoma on the Heel, Forefoot, and Hallux

Park HS, Kim JH, Cho MY, Chung KY, Roh MR

Background: Acral melanoma occurs on glabrous skin or the nail apparatus and is distinct from ultraviolet-related melanoma due to differing genetic alteration patterns. Although the pathogenesis of acral melanoma is...
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Prognostic Significance of Epidermal Growth Factor Receptor Expression in Distant Metastatic Melanoma from Primary Cutaneous Melanoma

Lee KH, Suh HY, Lee MW, Lee WJ, Chang SE

Background: Epidermal growth factor receptor (EGFR) is overexpressed in many cancers. However, EGFR expression in melanoma and its role are conflicting. Objective: This study aimed to evaluate EGFR expression in...
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Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects

Lu YP, Fan S, Liang Z, Song Y, Liu K, Zhou K, Wang X, Kang J, Yang Y, Liu X

Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the...
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Fucoidan Induces Apoptosis in A2058 Cells through ROS-exposed Activation of MAPKs Signaling Pathway

Ryu YS, Hyun JW, Chung HS

Fucoidan, a natural component of brown seaweed, has various biological activities such as anticancer activity, anti-oxidant, and anti-inflammatory against various cancer cells. However, the fucoidan has been implicated in melanoma...
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Clinical management of uveal melanoma: a comprehensive review with a treatment algorithm

Sayan M, Mamidanna S, Oncel D, Jan I, Vergalasova I, Weiner J, Ohri N, Acikalin B, Chundury A

Uveal melanoma (UM), the most frequently occurring non-cutaneous melanoma and most common primary intraocular malignancy in adults, arises from the melanocytes of the choroid in approximately 95% of cases. Prompt...
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