J Nutr Health.  2014 Oct;47(5):313-320. 10.4163/jnh.2014.47.5.313.

Hypoglycemic and antioxidant effects of jaceosidin in streptozotocin-induced diabetic mice

• Park E
• Kwon BM
• Jung IK
• Kim JH

• KMID: 2327164
• DOI: http://doi.org/10.4163/jnh.2014.47.5.313

Abstract

PURPOSE
In this study, we investigated the effects of jaceosidin on blood glucose regulation in type 1 diabetic mice.
METHODS
C57BL/6 mice were divided into four groups; normal control (Normal), diabetes control (D-Control), diabetes low-jaceosidin (D-0.005%), and diabetes high-jaceosidin (D-0.02%). Type 1 diabetes was induced by streptozotocin and mice were then fed a diet containing jaceosidin for eight weeks. Fasting blood glucose, oral glucose tolerance test, insulin tolerance test, lipid peroxidation, and antioxidant enzyme activities were assessed.
RESULTS
Jaceosidin supplementation for eight weeks had no effect on body weight, organ weight, and blood lipid profiles. However, jaceosidin supplementation significantly lowered fasting blood glucose level and reduced insulin resistance. We also found that jaceosidin supplementation increased antioxidant capacity by enhancement of catalase and GSH-px activities.
CONCLUSION
These results suggest that jaceosidin could be a therapeutic candidate to ameliorate hyperglycemia through increase of antioxidant enzyme activity.

Keyword

jaceosidin; diabetes mellitus; antioxidant; lipid peroxidation

MeSH Terms

Animals
Antioxidants*
Blood Glucose
Body Weight
Catalase
Diabetes Mellitus
Diet
Fasting
Glucose Tolerance Test
Hyperglycemia
Insulin
Insulin Resistance
Lipid Peroxidation
Mice*
Organ Size
Streptozocin
Antioxidants
Blood Glucose
Catalase
Insulin
Streptozocin

Figure

• 

  Fig. 1. Effects of jaceosidin intake on fasting blood glucose, oral glucose tolerance test and insulin tolerance test in STZ-induced mice. A: Fasting blood glucose levels after 8 weeks of diet, B: Oral glucose tolerance test (OGTT) was performed at 6 week of diet. C: Area of under curve (AUC) was calculated based on OGTT results. D: Insulin tolerance test (ITT) was performed at 7 week of diet. E: AUC was calculated based on ITT results.

Reference

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