Korean J Nutr.  2003 Dec;36(10):981-989.

Effects of Edible and Medicinal Plants Intake on Blood Glucose, Glycogen and Protein Levels in Streptozotocin Induced Diabetic Rats

• Lim SJ
• Han HK
• Ko JH

Abstract

The hypoglycemic effects of four edible plants (Angelicae tenuissimae (A. ten.), Pleurospermum kamtschaticum (P. kam.), Adenophora remotiflora (A. rem.) and Zanthoxylum schinifolium (Z. sch.)) in streptozotocin (STZ)-induced diabetic rats were investigated. Sprague-Dawley male rats weighing 190-230 g were induced diabetes mellitus by the STZ injection (45 mg/kg) into the tail vein and were divided into six groups ; normal, STZ-control and four edible plant groups (A. ten., P kam., A. rem. and Z. sch. groups). Normal and STZ-control groups were fed a AIN-93 diet and four groups of STZ-induced diabetic rats were fed one of each experimental diets containing 10% of the edible plant powder for 4 weeks. Diabetic rats showed the lower weight gain compared to the normal rats. In experimental groups except P. kam., AST activities were close to normal. A. ten. group were lowered ALT activities slightly. The plasma glucose levels of the diabetic experimental groups were significantly decreased at 4th week. The plasma insulin levels in diabetic experimental groups were not significantly different compared to the STZ-control group. The liver glycogen levels in STZ injected rats were significantly lower in compared to the normal rats. However no significant differences were found in response experimental plants intake in diabetic rats. The muscle glycogen were not significantly different among all the groups.

Keyword

Angelicae tenuissimae; Pleurospermum kamtschaticum; Adenophora remotiflora; Zanthoxylum schinifolium; streptozotocin-induced diabetic rats; hypoglycemic effect

MeSH Terms

Animals
Blood Glucose*
Campanulaceae
Diabetes Mellitus
Diet
Glycogen*
Humans
Hypoglycemic Agents
Insulin
Liver Glycogen
Male
Plants, Edible
Plants, Medicinal*
Plasma
Rats*
Rats, Sprague-Dawley
Streptozocin*
Veins
Weight Gain
Zanthoxylum
Blood Glucose
Glycogen
Hypoglycemic Agents
Insulin
Liver Glycogen
Streptozocin