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Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations

Sheu WH, Chan SP, Matawaran , Deerochanawong C, Mithal A, Chan J, Suastika K, Khoo CM, Nguyen HM, Linong J, Luk A, Yoon KH

The prevalence of obesity in Asia is of epidemic proportions, with an estimated 1 billion overweight/obese individuals in the region. The majority of patients with type 2 diabetes mellitus (T2DM)...
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Efficacy and Tolerability of Low-Dose Perampanel in Patients with Childhood-Onset Intractable Epilepsy

Park H, Ahn H, Jang HN, Kim HJ, Yum MS, Ko TS

PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of perampanel as adjunctive therapy in childhood-onset refractory epilepsy. METHODS: We retrospectively reviewed the medical records of 110...
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Efficacy and Tolerability of Low-Dose Perampanel in Patients with Childhood-Onset Intractable Epilepsy

Park H, Ahn H, Jang HN, Kim HJ, Yum MS, Ko TS

PURPOSE: The aim of this study was to evaluate the efficacy and tolerability of perampanel as adjunctive therapy in childhood-onset refractory epilepsy. METHODS: We retrospectively reviewed the medical records of 110...
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Weight Gain during Neoadjuvant Chemotherapy is Associated with Worse Outcome among the Patients with Operable Breast Cancer

Fang Q, Huang J, Gan L, Shen K, Chen X, Wu B

PURPOSE: This study was aimed at identifying the influence of initial weight and weight change during neoadjuvant chemotherapy (NAC) on pathologic complete response (pCR) and long-term survival in Chinese patients...
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Association Between Trp64arg Polymorphism of the β3 adrenoreceptor Gene and Female Sex in Obese Turkish Children and Adolescents

Yılmaz R, Ateş O, Gül A, Kasap T, Özer S, Ensari E

PURPOSE: The β3-adrenergic receptor (ADRB3) is expressed in visceral adipose tissue and has been speculated to contribute to lipolysis, energy metabolism, and regulation of the metabolic rate. In this study,...
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Postthyroidectomy obesity in a Korean population: does the extent of surgery matter?

Park MY, Nam SE, Park KS, Saindane M, Yoo YB, Yang JH, Ahn AL, Choi JK, Park WS

PURPOSE: The purpose of this study was to investigate the prevalence of postthyroidectomy obesity, and the relationship between the extent of thyroidectomy and obesity. METHODS: A survey conducted at an outpatient...
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Comparative study of liver injury induced by high-fat methionine- and choline-deficient diet in ICR mice originating from three different sources

Lee S, Kwak JH, Kim SH, Jeong TB, Son SW, Kim JH, Lim Y, Cho JY, Hwang DY, Kim KS, Jung YS

Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. It is characterized by the accumulation of lipids without alcohol intake and often progresses to non-alcoholic...
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The effects of coenzyme Q₁₀ supplement on blood lipid indices and hepatic antioxidant defense system in SD rats fed a high cholesterol diet

Kim HN, Jeon DG, Lim Y, Jang IS

A total of 24 SD rats were allotted to four treatment groups such as the control (CON), 1% of cholesterol diet (CHO), 0.5% of coenzyme Q₁₀ (COQ) and 1% of...
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Effect of Individual Low Sodium Dialysate on Blood Pressure, Interdialytic Weight Gain, Thirst and Intradialytic Discomfort In End-Stage Renal Disease Patients

Kim S, Choi Y

PURPOSE: The purpose of this paper was to identify blood pressure, interdialytic weight gain, thirst and intradialytic discomfort in subjects after applying individual low-sodium dialysis fluid (1,2,3 mEq/L) to hemodialysis...
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Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment

Steinman J, Shibli-Rahhal A

Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis...
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Effect of Yeonsan Ogye bioactive peptides on anti-oxidant indexes in rats' liver

Kim HW, Shim JH, Kim KN

PURPOSE: This study investigated the effect of bioactive Yeonsan Ogye peptides (YOPs) intake on changes in the hepatic anti-oxidant indexes in male rats. METHODS: Sprague-Dawley male rats were divided into 3...
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Registered dietitian nutritionists and perceptions of liberalizing the hemodialysis diet

Welte AL, Harpel T, Schumacher J, Barnes JL

BACKGROUND/OBJECTIVES: The objective of this study was to assess the level of awareness, comfort, and likelihood of liberalizing the hemodialysis diet in practicing renal registered dietitian nutritionists (RDN). SUBJECTS/METHODS: An original,...
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Interactions of Behavioral Changes in Smoking, High-risk Drinking, and Weight Gain in a Population of 7.2 Million in Korea

Kim YY, Kang HJ, Ha S, Park JH

OBJECTIVES: To identify simultaneous behavioral changes in alcohol consumption, smoking, and weight using a fixed-effect model and to characterize their associations with disease status. METHODS: This study included 7 000 529...
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Coexistence of Excessive Weight Gain and Celiac Disease in Children: An Unusual Familial Condition

Calcaterra V, Regalbuto , Madè A, Magistrali M, Leonard MM, Cena H

Excessive weight gain in children diagnosed with celiac disease (CD) is becoming more common. We describe 2 siblings (9-year and 6 months-old female and 6-year and 9 months-old male) with...
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A pilot study of gonadotropin-releasing hormone agonist combined with aromatase inhibitor as fertility-sparing treatment in obese patients with endometrial cancer

Zhang Z, Huang H, Feng F, Wang J, Cheng N

OBJECTIVE: This study aims to evaluate the effects and pregnancy outcomes of gonadotropin-releasing hormone agonist (GnRH agonist) combined with aromatase inhibitor (AI) in preserving the fertility of obese women with...
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Sodium-Glucose Cotransporter 2 Inhibitors for People with Type 1 Diabetes

Kim CH, Moon JS

Althowgh intensive insulin regimen is the main treatment in people with type 1 diabetes, glucose variability and weight gain remain as challenges for this treatment. Sodium-glucose cotransporter (SGLT) inhibitors (including...
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Correlates of the Pregnancy Experience and Attitude regarding Weight Change during Pregnancy in Primigravida Women

Shin G, Kim M

PURPOSE: We aimed to examine the correlations between pregnancy experience and attitude regarding weight change during pregnancy. METHODS: This correlative study was conducted from July 2017 to October 2017 by involving...
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Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation

Bae JY, Kim DY, Kwon YD, Song YH, Lim HH, Park HD, Lim JW

Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH...
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Outcome of Children with Severe Acute Malnutrition and Diarrhea: a Cohort Study

Bhatnagar , Kumar R, Dua R, Basu S, Kumar P

PURPOSE: Severe acute malnutrition (SAM) is an important public health problem which contributes to significant number of under five deaths. Protocol based management significantly decreases risk of deaths in children...
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Comparison of Improving Effects for Diabetic Erectile Dysfunction according to the Anti-Glycemic Agents: Phlorizin and Insulin

Park J, Kwon O, Cho SY, Cho MC, Paick JS, Kim SW

PURPOSE: To compare the improving effects of diabetic erectile dysfunction with two anti-glycemic agents; phlorizin and insulin. MATERIALS AND METHODS: Sixty Sprague-Dawley rats were divided into four groups (n=15 in each...
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