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Safety and Efficacy of Intravenous Thrombolysis in the 3- to 4.5-hour Window in Acute Ischemic Stroke Patients Who Have Both Diabetes Mellitus and History of Prior Stroke

Kim B, Lee JS, Park HK, Yung YB, Oh KC, Park JJ, Cho YJ, Kang K, Lee SJ, Kim JG, Cha JK, Kim DH, Bae HJ, Park TH, Park SS, Lee KB, Lee J, Lee BC, Lee M, Kim JT, Choi KH, Kim DE, Choi JC, Shin DI, Kwon JH, Kim WJ, Sohn SI, Hong JH, Park HJ, Jang SH, Park KY, Lee SH, Park JM, Hong KS

Background: For acute ischemic stroke (AIS) patients with history of prior stroke (PS) and diabetes mellitus (DM), intravenous recombinant tissue plasminogen activator (IV-tPA) therapy in the 3- to 4.5-hour window...
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Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice

Zhu Q, Zhou Q, Luo Xl, Zhang Xj, Li Sy

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these...
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Fatty Liver & Diabetes Statistics in Korea: Nationwide Data 2009 to 2017

Han E, Han KD, Lee Yh, Kim KS, Hong S, Park JH, Park CY, on Behalf of Fatty Liver Research Group of the Korean Diabetes Association

Background: This study investigated the changes of fatty liver disease prevalence in general Korean population. Methods: This study analyzed data from the Korean National Health Insurance Service from 2009 to 2017...
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The Ratio of Estimated Glomerular Filtration Rate Based on Cystatin C and Creatinine Reflecting Cardiovascular Risk in Diabetic Patients

Khang AR, Lee MJ, Yi D, Kang YH

Background: The ratio of estimated glomerular filtration rate (eGFR) based on cystatin C and creatinine (eGFRcystatin C/eGFRcreatinine ratio) is related to accumulating atherosclerosis-promoting proteins and increased mortality in several cohorts. Methods:...
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Glycemia according to the Use of Continuous Glucose Monitoring among Adults with Type 1 Diabetes Mellitus in Korea: A Real-World Study

Lee YB, Kim M, Kim JH

Background: We explored the association between continuous glucose monitoring (CGM) use and glycemia among adults with type 1 diabetes mellitus (T1DM) and determined the status of CGM metrics among adults...
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Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes

Wang J, Zhou H, Shao J, Zhang S, Jin J

Background: Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)...
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Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis

Kim HJ, Lee SJ, Sa S, Bae JH, Song G, Lee CW, Kim JH, Shim SR, Hong M, Han HW

Background: Little is known about the adverse events (AEs) associated with coronavirus disease 2019 (COVID-19) vaccination in patients with type 2 diabetes mellitus (T2DM). Methods: This study used vaccine AE reporting...
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Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases

Kong BS, Lee C, Cho YM

Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c...
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Machine Learning Approach to Drug Treatment Strategy for Diabetes Care

Fujihara K, Sone H

Globally, the number of people with diabetes mellitus has quadrupled in the past three decades, and approximately one in 11 adults worldwide have diabetes mellitus. Since both microvascular and macrovascular...
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Association between Visual Impairment and Nutritional Risk among Older Adults with Diabetes: A Population-Based Cross-Sectional Study

Yang E, Lee KH

Purpose Despite the high prevalence of visual impairment caused by diabetic retinopathy and nutritional problems among older adults with diabetes, evidence regarding factors related to nutritional risk in this population is...
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Endoscopic duodenal mucosal resurfacing for treating obesity and metabolic diseases: State-of-the-art review

Kim SH, Lee JK

Despite various advanced medical treatments for chronic metabolic diseases, such as type 2 diabetes and obesity, many fall short of their treatment goals. Bariatric surgery is one of the potential...
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Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice

Song NN, Huang X, Lu HL, Lu C, Chen J, Xu WX

  • KMID: 2541577
  • J Neurogastroenterol Motil.
  • 2023 Apr;29(2):250-261.
  • doi: 10.5056/jnm22052
Background/Aims The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients’ life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this...
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Correlation analysis of cancer incidence after pravastatin treatment

Yu J, Kim R, Shinn J, Park MY, Kim HS

Background: Few studies have investigated the cancer-preventive effects of statins, which are known to protect against cardio-cerebrovascular diseases. In this study, we analyzed the degree to which pravastatin, a low-potency...
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Risk for Newly Diagnosed Type 2 Diabetes Mellitus after COVID-19 among Korean Adults: A Nationwide Matched Cohort Study

Choi JH, Kim KM, Song K, Seo GH

Background: Coronavirus disease 2019 (COVID-19) can cause various extrapulmonary sequelae, including diabetes. However, it is unclear whether these effects persist 30 days after diagnosis. Hence, we investigated the incidence of...
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Implications of comorbidities in nonalcoholic fatty liver disease

Song SJ, Wong VWS

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Performance of Simple Fibrosis Score in Non-Alcoholic Fatty Liver Disease with and without Type 2 Diabetes

Chung SM, Kang MK, Moon JS, Park JG

This cross-sectional study enrolled 267 patients with metabolic risk factors and established non-alcoholic fatty liver disease in the prospective cohort. The performance of fibrosis-4 (FIB-4) score (≥1.3) to diagnose advanced...
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The art of diabetes care: guidelines for a holistic approach to human and social factors

Hashim MJ

A holistic approach to diabetes considers patient preferences, emotional health, living conditions, and other contextual factors, in addition to medication selection. Human and social factors influence treatment adherence and clinical...
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Effect of diabetes-specific oral nutritional supplements with allulose on weight and glycemic profiles in overweight or obese type 2 diabetic patients

Tak J, Bok M, Rho H, Park JH, Lim Y, Chon S, Lim H

BACKGROUND/OBJECTIVES: Diabetes-specific oral nutritional supplements (ONS) have anti-hyperglycemic effects, while D-allulose exerts anti-diabetic and anti-obesity effects. In this study, we investigated the efficacy and safety of diabetes-specific ONS, including allulose, on...
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Utilization of nutrition labels and related factors among patients with diabetes in Korea

Lee SJ, Han MA, Park J, Ryu SY

BACKGROUND/OBJECTIVES: The prevalence of diabetes has continued to increase globally. Changes in eating habits, lack of exercise, increased stress, and aging are major contributors. Glycemic control is the key strategy of diabetes...
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Association of advanced chronic kidney disease with diabetic retinopathy severity in older patients with diabetes: a retrospective cross-sectional study

Lee GW, Lee CH, Kim SG

Background: Despite the recent increasing trend in the prevalence of type 2 diabetes among older individuals, the relationship between diabetic retinopathy (DR) and chronic kidney disease (CKD) in these patients...
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