Lab Anim Res.  2016 Jun;32(2):91-98. 10.5625/lar.2016.32.2.91.

Anti-inflammatory effect of egg white-chalcanthite and purple bamboo salts mixture on arthritis induced by monosodium iodoacetate in Sprague-Dawley rats

Affiliations
  • 1Department of Bio Applied Toxicology, Graduate school of Hoseo University, Asan, Korea. bshan@hoseo.edu
  • 2Hoseo Toxicological Research Center, Hoseo University, Asan, Korea.
  • 3Insan Bamboo Salt Inc. and Insan Korean Medical Cancer Clinic, Hamyang, Korea.

Abstract

The aim of this study is to investigate the potential of anti-osteoarthritis effects on egg white-chalcanthite (EC), purple bamboo salts (PBS), and a mixture of EC and PBS (EC+PBS). EC is a mixture of egg white and pulverized chalcanthite. PBS has been widely used as one of functional foods in Korea and shows unique features compared with common salt. Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate (MIA, 4mg/kg bw) in Sprague-Dawley (SD) rats. Test substances were administered once daily for 6 weeks at doses of 10 mg EC, EC+100 mg PBS, EC+200 mg PBS before and after MIA injection. Each substance was assessed by blood chemistry parameters, and by serum cytokines including IL-1β and IL-6, and nitric oxide (NO) and prostaglandin-E2 (PGE2). Structural changes of articular cartilage were also evaluated by histopathological examination. As a result, body weight and blood chemistry parameter were not different in all experimental groups. EC+PBS mixture reduced the production of PGE2, NO, IL-1β, and IL-6. In histological grade of osteoarthritis, EC+PBS mixture had a tendency to ameliorate damage of articular cartilage induced by MIA in a dose-dependent manner. In conclusion, EC+PBS mixture was demonstrated to have a potential for anti-inflammatory effect against osteoarthritis induced by MIA in a dose-dependent manner.

Keyword

arthritis; purple bamboo salts (PBS); egg white-chalcanthite (EC); monosodium iodoacetate (MIA)

MeSH Terms

Animals
Arthritis*
Body Weight
Cartilage, Articular
Chemistry
Cytokines
Dinoprostone
Egg White
Functional Food
Injections, Intra-Articular
Interleukin-6
Korea
Nitric Oxide
Osteoarthritis
Ovum*
Rats
Rats, Sprague-Dawley*
Salts*
Cytokines
Dinoprostone
Interleukin-6
Nitric Oxide
Salts
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