Nutr Res Pract.  2013 Aug;7(4):273-280.

Bamboo salt attenuates CCl4-induced hepatic damage in Sprague-Dawley rats

Affiliations
  • 1Department of Food Science and Nutrition, Pusan National University, 30 Jangjun-dong, Geumjung-gu, Busan 609-735, Korea. kunypark@pusan.ac.kr
  • 2Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, PR China.

Abstract

Bamboo salt, a Korean folk medicine, is prepared with solar salt (sea salt) and baked several times at high temperatures in a bamboo case. In this study, we compared the preventive effects of bamboo salt and purified and solar salts on hepatic damage induced by carbon tetrachloride in Sprague-Dawley rats. Compared with purified and solar salts, bamboo salts prevented hepatic damage in rats, as evidenced by significantly reduced serum levels of aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase (P < 0.05). Bamboo salt (baked 9x) triggered the greatest reduction in these enzyme levels. In addition, it also reduced the levels of the proinflammatory cytokines interleukin (IL)-6, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha. Histopathological sections of liver tissue demonstrated the protective effect of bamboo salt, whereas sections from animals treated with the other salt groups showed a greater degree of necrosis. We also performed reverse transcription-polymerase chain reaction and western blot analyses of the inflammation-related genes iNOS, COX-2, TNF-alpha, and IL-1beta in rat liver tissues. Bamboo salt induced a significant decrease (~80%) in mRNA and protein expression levels of COX-2, iNOS, TNF-alpha, and IL-1beta, compared with the other salts. Thus, we found that baked bamboo salt preparations could prevent CCl4-induced hepatic damage in vivo.

Keyword

Bamboo salt; hepatic damage; CCl4; cytokines; inflammation

MeSH Terms

Alanine Transaminase
Animals
Aspartate Aminotransferases
Blotting, Western
Carbon Tetrachloride
Cytokines
Inflammation
Interferons
Interleukins
L-Lactate Dehydrogenase
Liver
Medicine, Traditional
Necrosis
Rats
Rats, Sprague-Dawley
RNA, Messenger
Salts
Tumor Necrosis Factor-alpha
Alanine Transaminase
Aspartate Aminotransferases
Carbon Tetrachloride
Cytokines
Interferons
Interleukins
L-Lactate Dehydrogenase
RNA, Messenger
Salts
Tumor Necrosis Factor-alpha
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