Korean J Pediatr Infect Dis.  2010 Jun;17(1):30-35.

Causative Organisms of Community Acquired Urinary Tract Infection and Their Antibiotic Susceptibility at a Secondary hospital in Korea

• Jo YJ
• Lee EJ
• Choi KM
• Eun YM
• Yoo HJ
• Kim CH
• Lee HH
• Kim PK

Abstract

PURPOSE
We investigated the causative organism and its antibiotic susceptibility of community acquired urinary tract infection (UTI) in children at a secondary hospital to test the adequacy of the current guidelines.
METHODS
Children diagnosed with UTI at the Department of Pediatrics, Kwandong University Myongji Hospital by pyuria and bacterial growth of greater than 1.0x10(5) CFU/mL on clean catch midstream urine from January 2005 to December 2008 were studied retrospectively. The epidemiologic data, causative organism, and the antibiotic susceptibility were analyzed.
RESULTS
Sixty two children were diagnosed with sixty four cases of UTI's. Two bacteria were isolated in one case and thus data on 65 urine cultures were analyzed. The male:female ratio was 1.6:1 and 78.1% were less than 12 months of age. Escherichia coli was the predominant cause consisting of 53 cases (82.8%) of the cases. K. pneumoniae (5), Enterobacter (4), Enterococcus (1), beta-streptococcus (1), Diphtheroides (1) were isolated. The antibiotic resistance of E. coli were as follows; ampicillin 69.8%, cefotaxime 1.9%, gentamicin 15.1%, amikacin 0.0%, levofloxacin 1.9%, and trimethoprim/sulfamethoxazole 26.4%. Only one case of the E. coli was extended spectrum beta-lactamase (ESBL) positive.
CONCLUSION
Compared to prior reports from other tertiary hospitals in Korea, E. coli was the predominant cause in childhood UTI and the rate of ESBL positivity was low. The antibiotic resistance was also different compared to prior reports. We conclude that a difference in the cause and antibiotic resistance of childhood UTI exists between centers and this should be taken into consideration when prescribing antibiotics for childhood UTIs.

Keyword

Urinary Tract Infection; Organism; Antibiotics; Susceptibility

MeSH Terms

Amikacin
Ampicillin
Anti-Bacterial Agents
Bacteria
beta-Lactamases
Cefotaxime
Child
Drug Resistance, Microbial
Enterobacter
Enterococcus
Escherichia coli
Gentamicins
Humans
Korea
Ofloxacin
Pediatrics
Pneumonia
Pyuria
Retrospective Studies
Tertiary Care Centers
Urinary Tract
Urinary Tract Infections
Amikacin
Ampicillin
Anti-Bacterial Agents
Cefotaxime
Gentamicins
Ofloxacin
beta-Lactamases