Korean J Anat.
2000 Oct;33(5):519-527.
Morphological Effect of Chronic Alcohol Drinking upon the Gastric Mucosa of Rats
- Affiliations
-
- 1Department of Anatomy, College of Medicine, Pusan National University, Pusan, Korea.
- 2Department of Internal Medicine, College of Medicine, Soonchunhyang, Choongnam, Korea.
- 3Department of Anatomy, College of Medicine, University of Ulsan, Seoul, Korea.
Abstract
- In order to investigate the effect of chronic alcohol drinking upon the gastric mucosa of rats, Sprague-Dawley rats (200~235 g) had drunken 10% alcohol in stead of water and were maintained on regular feed. They drank about 20cc of 10% alcohol a day. The experimental groups sacrificed in 1, 2, 4 and 8 weeks. The gastric mucosa from the gastric body near by the fundus and the gastric body in the vicinity of the pylorus were fixed in neutral formalin, dehydrated in graded ethanol and embedded in paraffin. They were sectioned and stained with hematoxylin and eosin, and stained with alcian blue pH 2.5. The results were as follows: 1. Mucosal epithelium of the rat destroyed a little in some place, but the damage was not severe in all the experimental groups. Migrating cells and parietal cells covered the damaged places. 2. In the mucosa of the gastric body near by the fundus, the cells of the gastric gland showed positive reaction with alcian blue pH 2.5 and increased in number at 1 week. The number and reactivity of the cells decreased at 4 and 8 weeks of the experiment. 3. The surface mucous cells of the gastric pits in the body near by the pylorus decreased in number. The mucous neck cells of the gastric gland also decreased in number with time. 4. The cells in the base of the gastric gland showed alcian blue pH 2.5 positive at 4 and 8 weeks of the experiment. 5. The thickness of the gastric mucosa in all the experimental groups decreased in comparison with that of normal gastric mucosa.
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