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Overexpression of HER2/HER3 and clinical feature of ovarian cancer

Chung YW, Kim S, Hong JH, Lee JK, Lee NW, Lee YS, Song JY

OBJECTIVES: Human epidermal growth factor receptor-2 (HER2) and 3 (HER3) belong to the epidermal growth factor receptor (EGFR) family of transmembrane receptor tyrosine kinases. In this study, we assessed HER2/HER3...
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Comparison of the Impact of an Optimized Ice Cooling Vest and a Paraffin Cooling Vest on Physiological and Perceptual Strain

Zare M, Dehghan H, Yazdanirad S, Khoshakhlagh AH

BACKGROUND: Ice cooling vests can cause tissue damage and have no flexibility. Therefore, these two undesirable properties of ice cooling vest were optimized, and the present study was aimed to...
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A large thymic mass with persistent active tissue in an elderly cadaver

Tripathy P, Chaudhary , Gaikwad MR, Britto NJ

Thymus is an encapsulated organ having its bilateral origin from the third pharyngeal pouch. It appears to be a single organ but actually it is bilobed. It attains its maximum...
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Electroretinography Changes in Feline Model of Iodoacetic Acid-induced Retinal Degeneration

Kim C, Lee M, Lee SU, Lee SJ

PURPOSE: We explored changes in photoreceptor function and histology in an iodoacetic acid (IAA)-induced model of feline retinal degeneration. METHODS: From January to October 2014, we studied 11 adult felines (22...
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Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time

Lee M, Chun SM, Sung CO, Kim SY, Kim TW, Jang SJ, Kim J

BACKGROUND: Microsatellite instability (MSI) analysis is becoming increasingly important in many types of tumor including colorectal cancer (CRC). The commonly used MSI tests are either time-consuming or labor-intensive. A fully...
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Landscape of Actionable Genetic Alterations Profiled from 1,071 Tumor Samples in Korean Cancer Patients

Lee SH, Lee B, Shim JH, Lee KW, Yun JW, Kim SY, Kim TY, Kim YH, Ko YH, Chung HC, Yu CS, Lee J, Rha SY, Kim TW, Jung KH, Im SA, Moon HG, Cho S, Kang JH, Kim J, Kim SK, Ryu HS, Ha SY, Kim JI, Chung YJ, Kim C, Kim HL, Park WY, Noh DY, Park K

PURPOSE: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian...
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Paraffinoma induced bilateral preauricular cheek skin defects

Heo JW, Kim BK

“Paraffinoma” is a well-recognized complication of paraffin oil injection into various body parts for an aesthetic purpose. After a variable latency phase, paraffinoma can present as a wide range of...
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Early fragment removal on in vitro fertilization day 2 significantly improves the subsequent development and clinical outcomes of fragmented human embryos

Kim SG, Kim YY, Park JY, Kwak SJ, Yoo CS, Park IH, Sun HG, Kim JW, Lee KH, Park HD, Chi HJ

OBJECTIVE: To determine whether fragment removal on in vitro fertilization (IVF) day 2 improved the subsequent development and pregnancy outcomes of fragmented embryos compared to similar-grade embryos without fragment removal. METHODS:...
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IRB review points for studies utilizing paraffin blocks archived in the pathology laboratory

Kim YJ, Jeong CR, Park JS

In the personalized medicine era, utilizing paraffin blocks in pathology archives for investigating human diseases has come into the limelight. This archived material with clinical data will reduce the research...
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The Major Role of NF-κB in the Depth of Invasion on Acral Melanoma by Decreasing CD8⁺ T Cells

Usman HA, Hernowo BS, Tobing MD, Hindritiani R

BACKGROUND: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor κB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in...
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Let Archived Paraffin Blocks Be Utilized for Research with Waiver of Informed Consent

Kim YJ, Park JS, Ko K, Jeong CR

Advances in biomedical and genetic research have contributed to more effective public health improvement via bench-to-bed research and the emergence of personalized medicine. This has certainly showcased the importance of...
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Androgen receptor as a prognostic biomarker and therapeutic target in uterine leiomyosarcoma

Baek MH, Park JY, Park Y, Kim KR, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Nam JH

OBJECTIVE: To investigate the expression of androgen receptor (AR) and its correlation with disease status and survival outcome in uterine leiomyosarcoma with other hormone receptors. METHODS: The medical records and paraffin...
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Contralateral Internal Mammary Lymphadenopathy Mimicking Metastasis in a Patient with a History of Breast Cancer and Prior Interstitial Mammoplasty by Paraffin Injection: MRI, PET-CT, and Pathological Findings

Nam KJ, Choo KS, Kim JY

Foreign body injections into breasts may produce foreign body reactions, fibrosis, and local swelling of involved lymph nodes, which can be misdiagnosed as metastasis or malignancy. Here, the authors report...
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Histomorphological changes in the common carotid artery of the male rat in induced hypogonadism

Cheruiyot , Olabu B, Kamau M, Ongeti K, Mandela P

The role of androgens in the development of cardiovascular diseases remains controversial. The current study therefore sought to determine the changes in the histomorphology of the common carotid artery of...
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Programmed Death-Ligand 1 Expression and Its Correlation with Lymph Node Metastasis in Papillary Thyroid Carcinoma

An HJ, Ko GH, Lee JH, Lee JS, Kim DC, Yang JW, Kim MH, Kim JP, Jung EJ, Song DH

BACKGROUND: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited....
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Angiomyolipoma of the Liver without a Fat Component, Mimicking a Hepatocellular Carcinoma

Woo YM, Ryu SH, Min JW, Kim MR, Park TY, Moon JS, Kang YK

Angiomyolipoma (AML) is a rare benign mesenchymal tumor in the liver, which is composed of blood vessels, smooth muscle, and adipose cells. The proportion of each component varies, making a...
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Paraffin Granuloma Associated with Buried Glans Penis-Induced Sexual and Voiding Dysfunction

Chon W, Koo JY, Park MJ, Choi KU, Park HJ, Park NC

A paraffinoma is a type of inflammatory lipogranuloma that develops after the injection of an artificial mineral oil, such as paraffin or silicon, into the foreskin or the subcutaneous tissue...
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The use of human mature cystic ovarian teratoma as a model to study the development of human lymphatics

Al-Jomard , Amarin Z

The angiogenic theory to the development of human lymphatics is not clear. The objective of this study was to investigate the development of human lymphatics. Semi-thin and thin paraffin sections...
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Acellular Dermal Matrices and Paraffinoma: A Modern Tool for a Nearly Obsolete Disease

Grassetti , Torresetti M, Scalise A, Lazzeri D, Di Benedetto G

Paraffinoma is a destructive complication of paraffin oil injection, usually associated with massive tissue destruction, thus requiring radical surgery and subsequent complex reconstruction. Although breast and penile paraffinomas have been...
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Conditioned Medium Derived from Salidroside-Pretreated Mesenchymal Stem Cell Culture Ameliorates Mouse Lipopolysaccharide-Induced Cerebral Neuroinflammation-Histological and Immunohistochemical Study

El Maadawi ZM

BACKGROUND AND OBJECTIVES: Neuroinflammation is involved in the pathogenesis of neurodegenerative disorders. Conditioned medium (CM) derived from bone marrow mesenchymal stem cells (MSCs) revealed substantial benefits due to its rich...
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