J Korean Med Sci.
2001 Jun;16(3):313-316. 10.3346/jkms.2001.16.3.313.
Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues
- Affiliations
-
- 1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. dskim@hmc.hanyang.ac.kr
- KMID: 1129903
- DOI: http://doi.org/10.3346/jkms.2001.16.3.313
Abstract
- The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Activities of Hepatic Enzymes for Ethanol Metabolism in Cholestatic Rats with Acute Ethanol Intoxication
- Effects of high taurocholate load on activities of hepatic alcohol metabolizing enzymes
- The Effects of Castration and Sex Hormone Administration on Lactic and Malic Dehydrogenase Activities in the Testis and the Prostate Tissues of Male Rabbits
- Effects of Aging on the Gastric and Hepatic Alcohol Dehydrogenase Activities in Rats
- The Extract of Limonium tetragonum Protected Liver against Acute Alcohol Toxicity by Enhancing Ethanol Metabolism and Antioxidant Enzyme Activities
