Infect Chemother.
2004 Apr;36(2):68-74.
In Vitro Activities of Gatifloxacin against Bacteria isolated from Respiratory Specimens of Patients of University Hospitals in Korea
- Affiliations
-
- 1Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, Korea. leekcp@yumc.yonsei.ac.kr
- 3Brain Korea 21 Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
- 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 5Handok Pharma Central Laboratory, Seoul, Korea.
Abstract
-
BACKGROUND: Gatifloxacin, a new 8-methoxyquinolone, has a broad-spectrum activity with expanded potency against respiratory pathogens. In this study, we examined the in vitro activity of gatifloxacin and comparators against recently isolated bacteria from respiratory specimens of patients in Korean hospitals.
METHODS
Forty-nine isolates were from respiratory specimens of patients with acute exacerbations of chronic lower respiratory infections in eight university hospitals and 108 isolates were from respiratory specimens from patients of Yonsei University Hospital. Minimum inhibitory concentrations (MICs) were determined by NCCLS agar dilution method.
RESULTS
MIC90 of gatifloxacin for Streptococcus pneumoniae was 1 g/mL, which was 8-fold and 2-fold lower than those of ciprofloxacin and levofloxacin, respectively. All strains of Haemophilus in fluenzae and Moraxella (Branhamella) catarrhalis were inhibited by < or =0.06 g/mL and < or =0.25 g/mL of gatifloxacin, respectively, and were susceptible to all fluoroquinolones tested. MIC90 of gatifloxacin for Klebsiella pneumoniae was 0.06 g/mL, which was 2-fold lower than those of levofloxacin and moxifloxacin.
CONCLUSION
Gatifloxacin is highly active against S. pneumoniae, H. influenzae and M. (B.) catarrhalis isolated from respiratory specimens of patients of university hospitals in Korea.
Keyword
MeSH Terms
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- In vitro Antimicrobial Activity of Cefcapene against Clinical Isolates
- In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea
- In Vitro Activities of Panipenem against Clinical Isolates of Aerobic and Anaerobic Bacteria
- Epizootiological and Bacteriological Studies of Bovine Tuberculosis in Korea -Report 2 A Study on the Acid-Fast Bacteria Isolated from Tuberculin Reactors of Dairy Cattle in 1971
- Trends of Anaerobic Bacteria Isolated from Clinical Specimens
