Infect Chemother.  2005 Jun;37(3):133-137.

In vitro Antimicrobial Activity of Cefcapene against Clinical Isolates

• Choo EJ
• Kwak YG
• Lee MS
• Jeong JY
• Choi SH
• Kim NJ
• Kim YS
• Woo JH
• Ryu J

Abstract

BACKGROUND: Cefcapene pivoxil hydrochloride is a new oral cephem which has a broad-spectrum activity with expanded potency against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus, as well as Gram-negative bacteria. In this study, we examined the in vitro activity of cefcapene against recently isolated clinical specimens from patients in a tertiary hospital.
MATERIALS AND METHODS
We tested the in vitro antimicrobial activities of cefcapene and other cephalosporins against 450 clinical isolates from of patients in Asan Medical Center. Minimal inhibitory concentrations (MICs) were determined by agar dilution method according to the recommendations of National Committee for Clinical Laboratory Standards.
RESULTS
Compared with other cephalosporins (cefaclor, cefpodoxime, and cefixime), cefcapene had lower MIC distributions for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and methicillin-susceptible S. aureus. Cefcapene had variable activity against Enterobateriaceae.
CONCLUSION
Cefcapene had excellent in vitro antimicrobial activities against common typical bacterial respiratory tract pathogens and methicillin-susceptible S. aureus. Cefcapene appears to be a promising agent for treatment of community-acquired respiratory tract infections and infections caused by methicillin-susceptible S. aureus.

Keyword

Cefcapene; Cephalosporin; Minimal inhibitory concentrations

MeSH Terms

Agar
Cephalosporins
Chungcheongnam-do
Gram-Negative Bacteria
Gram-Positive Bacteria
Haemophilus influenzae
Humans
Moraxella (Branhamella) catarrhalis
Respiratory System
Respiratory Tract Infections
Staphylococcus aureus
Streptococcus
Streptococcus pneumoniae
Tertiary Care Centers
Agar
Cephalosporins