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NJK14047 Suppression of the p38 MAPK Ameliorates OVA-Induced Allergic Asthma during Sensitization and Challenge Periods

Lee JH, Son SH, Kim NJ, Im DS

p38 MAPK has been implicated in the pathogenesis of asthma as well as pro-allergic Th2 cytokines, orosomucoid-like protein isoform 3 (ORMDL3), regulation of sphingolipid biosynthesis, and regulatory T cell-derived IL-35....
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Clinical Characteristics of Patients with Probable Coronavirus Disease 2019-associated Pulmonary Aspergillosis at a Tertiary Care Hospital in the Republic of Korea: A Case Series

Hwang YH, Kim D, Kang CK, Choe PG, Park WB, Kim NJ, Oh Md

Background: Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) is a life-threatening invasive fungal infection in critically ill patients with COVID-19. However, only a few studies have reported CAPA in the...
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How We Have Treated Severe to Critically Ill Patients With Coronavirus Disease 2019 in Korea

Park DH, Kang CK, Choe PG, Kim NJ, Park WB, Oh Md

Since 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and the coronavirus disease 2019 (COVID-19) pandemic currently continues. In response to this unprecedented pandemic, several researchers and...
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p38 MAPK Inhibitor NJK14047 Suppresses CDNB-Induced Atopic Dermatitis-Like Symptoms in BALB/c Mice

Lee JH, Son SH, Kim NJ, Im DS

Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Suppression of MAPKs and NF-κB is implicated as a vital mechanism of action of several traditional Chinese medicines for AD therapy....
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Success factors for the Development of Health Community Organizing in: 148 Village, Gangbuk-gu, Seoul

Jong-Won JW, Kim JH, Lee SH, Kim NJ, Park WS

Objectives: The purpose of this study was to examine the success factors for the development of health community organizing in regard to its perspective in: 148 village, Gangbuk-gu, Seoul. Methods: We...
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Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

Park DH, Lee CM, Chang E, Kang CK, Park WB, Kim NJ, Choe PG, Oh Md

Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has...
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Changes in Anxiety Level and Personal Protective Equipment Use Among Healthcare Workers Exposed to COVID-19

Park DH, Lee E, Jung J, Kang CK, Song KH, Choe PG, Park WB, Bang JH, Kim ES, Kim HB, Park SW, Kim NJ, Oh Md

Background: The relationship between changes in anxiety levels and personal protective equipment (PPE) use is yet to be evaluated. The present study assessed this relationship among healthcare workers (HCWs) involved...
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Kinetics of Neutralizing Antibody Responses Against SARS-CoV-2 Delta Variant in Patients Infected at the Beginning of the Pandemic

Choe PG, Kim Y, Chang E, Kang CK, Kim NJ, Cho NH, Park WB, Oh Md

We investigated the kinetics of the neutralizing antibody responses to the severe acute respiratory syndrome-coronavirus-2 delta variant over the course of 1 year in 16 patients infected at the beginning...
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Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study

Mo H, Lee J, Park JB, Park SC, Kim YH, Han A, Jung IM, Ha J, Kim NJ, Min S

Background: The use of organs from donors with infection is limited because of the possibility of transmission. We aimed to investigate the transmission after deceased donor transplantation with bloodstream infection...
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A Direct Rapid Phenotypic Antimicrobial Susceptibility Test Enables Early Selection of Optimal Antibiotics to Treat Bacteremia in COVID-19 Patients

Park DH, Chang E, Kang CK, Choe PG, Kim NJ, Kim TS, Park WB, Oh Md

Background: Co-infection with bacteria and severe acute respiratory syndrome coronavirus 2 may result in greater use of healthcare resources and a poor prognosis. Therefore, early selection and use of optimal...
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Prevalence of Multidrug-Resistant Tuberculosis in HIV/Tuberculosis Co-Infected Patients

Lee CM, Lee E, Bang JH, Park SW, Park WB, Oh Md, Kim NJ

Tuberculosis (TB) is a common opportunistic infection in human immunodeficiency virus (HIV)-infected patients. Patients with multidrug-resistant (MDR)-TB have poor outcomes. This study aimed to determine the prevalence of MDR-TB in HIV/TB...
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Work Restrictions for Healthcare Personnel with Potential In-hospital Exposure to SARS-CoV-2: Experience at a Tertiary Hospital

Jo HJ, Kim JS, Choe PG, Lee HY, Chang E, Jung H, Kang CK, Park WB, Kim NJ, Oh Md

Applying work restrictions for asymptomatic healthcare personnel (HCP) with potential exposure to coronavirus disease 2019 (COVID-19) is recommended to prevent transmission from potentially contagious HCP to patients and other HCP....
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Microbial Contamination Rates of Hospital Privacy Curtains: A Prospective Culture Study

Lee CM, Goh HY, Lee HY, Oh YR, Choe PG, Park WB, Kim NJ

Contaminated curtains are a reservoir of microorganisms that can be a source of infection outbreak. In order to investigate the contamination rates of hospital curtains over time, we obtained cultures...
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Microbiologic Diagnosis of Pyogenic Spondylitis

Kim NJ

Pyogenic spondylitis requires long-term antibiotics treatment and identification of the etiologic microorganism is essential. The first test in the microbiologic diagnosis of pyogenic spondylitis is a blood culture. Any microorganisms...
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Developing a Framework for Pandemic COVID-19 Vaccine Allocation: a Modified Delphi Consensus Study in Korea

Choi MJ, Choi WS, Seong H, Choi JY, Kim JH, Kim YJ, Cho EY, Kim DH, Park H, Lee H, Kim NJ, Song JY, Cheong HJ, Kim SI, Peck KR

Background: This study presents a framework for determining the allocation and distribution of the limited amount of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods: After analyzing the pandemic...
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Antibody Responses One Year after Mild SARS-CoV-2 Infection

Choe PG, Kim KH, Kang CK, Suh HJ, Kang E, Lee SY, Kim NJ, Yi J, Park WB, Oh Md

Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic...
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Clinical Application of the Standard Q COVID-19 Ag Test for the Detection of SARS-CoV-2 Infection

Oh SM, Jeong H, Chang E, Choe PG, Kang CK, Park WB, Kim TS, Kwon WY, Oh MD, Kim NJ

We evaluated the Standard Q COVID-19 Ag test for the diagnosis of coronavirus disease 2019 (COVID-19) compared to the reverse transcription-polymerase chain reaction (RT-PCR) test. We applied both tests to patients...
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Development of Free Fatty Acid Receptor 4 (FFA4/GPR120) Agonists in Health Science

Son SE, Kim NJ, Im DS

Till the 21st century, fatty acids were considered as merely building blocks for triglycerides, phospholipids, or cholesteryl esters. However, the discovery of G protein-coupled receptors (GPCRs) for free fatty acids at...
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Anti-GQ1b Antibody Syndrome Presenting with Severe Headache

Choi SY, Kim KH, Kim JK, Kim NJ, Kim YH, Choi KD

Anti-GQ1b antibody syndrome, including Miller Fisher syndrome, Guillain-Barré syndrome with ophthalmoplegia, Bickerstaff’s brainstem encephalitis, and acute ophthalmoplegia without ataxia, has overlapped clinical symptoms and mostly associated with anti-GQ1b immunoglobulin (Ig)...
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The Importance of Proper History Taking: Asking a Fever Pattern in Patients with Vivax Malaria

Chang Ej, Song KH, Park WB, Bang JH, Kim ES, Park SW, Kim NJ

Characteristic fever patterns of malarial infection are clues for diagnosis. However, checking fever patterns in febrile patients has been usually missed, and unnecessary tests have been performed. We reviewed electrical...
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