Infect Chemother.  2003 Dec;35(6):423-433.

In Vitro Activities of Panipenem against Clinical Isolates of Aerobic and Anaerobic Bacteria

Affiliations
  • 1Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Korea. leekcp@yumc.yonsei.ac.kr
  • 2Brain Korea 21 Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
  • 3Department of Microbiology, Kitasato University School of Medicine, Sagamihara City, Japan.

Abstract

BACKGROUND: Panipenem is a carbapenem antimicrobial agent which has been shown to have broad-spectrum activities against various aerobic and anaerobic bacteria. In this study, in vitro activities of panipenem against recent clinical isolates of aerobic and anaerobic bacteria were determined.
METHODS
Aerobic and anaerobic bacteria were isolated in 2001 and in 2000-2001, respectively, from a tertiary-care hospital patients. Antimicrobial susceptibility was tested by the NCCLS agar dilution method.
RESULTS
MIC90s of panipenem were:similar to those of imipenem for aerobic gram-positive cocci and Enterobacteriaceae; slightly lower than those of meropenem for gram-positive cocci, but slightly higher for Enterobacteriaceae; slightly higher than imipenem for A. baumannii, but similar for anaerobic bacteria.
CONCLUSION
MIC90s of panipenem were similar to those of imipenem for aerobic and anaerobic bacterial isolates, which frequently involve respiratory, urinary, intraabdominal and wound infections. When imipenem breakpoints are applied to interpret panipenem susceptibilities, panipenem can be considered useful for the treatment of various infections, including nosocomially acquired ones.

Keyword

Panipenem; Aerobes; Anaerobes; Antimicrobial activity

MeSH Terms

Agar
Bacteria, Anaerobic*
Enterobacteriaceae
Gram-Positive Cocci
Humans
Imipenem
Wound Infection
Agar
Imipenem
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