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Artificial intelligence for endoscopy in inflammatory bowel disease

Takenaka K, Kawamoto A, Okamoto R, Watanabe M, Ohtsuka K

Inflammatory bowel disease (IBD), with its 2 subtypes, Crohn’s disease and ulcerative colitis, is a complex chronic condition. A precise definition of disease activity and appropriate drug management greatly improve...
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Stem cell-based therapy for inflammatory bowel disease

Shimizu H, Suzuki K, Watanabe M, Okamoto R

Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a...
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In Vitro Activities of Panipenem against Clinical Isolates of Aerobic and Anaerobic Bacteria

Lee K, Lee WH, Yong D, Yum JH, Chong Y, Okamoto R, Inoue M

  • KMID: 2285145
  • Infect Chemother.
  • 2003 Dec;35(6):423-433.
BACKGROUND: Panipenem is a carbapenem antimicrobial agent which has been shown to have broad-spectrum activities against various aerobic and anaerobic bacteria. In this study, in vitro activities of panipenem against...
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Why do antimicrobial agents become ineffectual?

Inoue M, Kuga A, Shimauchi , Yano H, Okamoto R

Antibiotic resistance has evolved over the past 50 years from a merely microbiological curiosity to a serious medical problem in hospitals all over the world. Resistance has been reported in...
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Combination of leucine-rich alpha-2 glycoprotein and fecal markers detect Crohn’s disease activity confirmed by balloon-assisted enteroscopy

Kawamoto A, Takenaka K, Hibiya S, Kitazume Y, Shimizu H, Fujii T, Saito E, Ohtsuka K, Okamoto R

Background/Aims: Endoscopic activity confirmed by enteroscopy is associated with poor clinical outcome in Crohn’s disease (CD). We investigated which of the existing biomarkers best reflects endoscopic activity in CD patients...
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Characteristics of Extended-spectrum Beta-lactam Hydrolyzing Activity of Klebsiella pneumoniae and Escherichia coli Strains Isolated from Clinical Specimens

Chong Y, Lee K, Okamoto R, Inoue M

  • KMID: 1548825
  • Korean J Infect Dis.
  • 1997 Nov;29(6):477-486.
BACKGROUND: Increase in Escherichia coli and Klebsiella pneumoniae isolates with extended- spectrum beta-lactamase (ESBL) have been noted recently in Korea. Current NCCLS disk diffusion test is not sensitive to detect...
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Evaluation of bone substitutes for treatment of peri-implant bone defects: biomechanical, histological, and immunohistochemical analyses in the rabbit tibia

dos Santos PL, de Molon R, Queiroz TP, Okamoto R, de Souza Faloni AP, Gulinelli , Luvizuto E, Garcia IR

PURPOSE: We sought to evaluate the effectiveness of bone substitutes in circumferential peri-implant defects created in the rabbit tibia. METHODS: Thirty rabbits received 45 implants in their left and right tibia....
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