J Korean Med Sci.
2002 Dec;17(6):737-742. 10.3346/jkms.2002.17.6.737.
In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea
- Affiliations
-
- 1Department of Clinical Pathology and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Korea.
- 2Department of Internal Medicine, Korea University College of Medicine, Korea.
- 3Division of Infectious Diseases, Asan Medical Center, and Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Korea.
- 4Department of Internal Medicine, College of Medicine, the Catholic University of Korea, Seoul, Korea. infect@cmc.cuk.ac.kr
- 5Department of Clinical Pathology, College of Medicine, the Catholic University of Korea, Seoul, Korea.
- 6LGCI/Life Science, Seoul, Korea.
- KMID: 648780
- DOI: http://doi.org/10.3346/jkms.2002.17.6.737
Abstract
- Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in vitro activities of gemifloxacin, gatifloxacin, moxifloxacin, levofloxacin, ciprofloxacin, and other commonly used antimicrobial agents against 1,689 bacterial strains isolated at four Korean university hospitals during 1999-2000. Minimum inhibitory concentrations (MICs) were determined using the agar dilution method of National Committee for Clinical Laboratory Standards. Gemifloxacin had the lowest MICs for the respiratory pathogens: 90% of Streptococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae were inhibited by 0.06, 0.03, and 0.03 mg/L, respectively. Gemifloxacin was more active than the other fluoroquinolones against methicillin-susceptible Staphylococcus aureus, coagulase-negative staphylococci, streptococci, and Enterococcus faecalis. The MIC90s of gemifloxacin for Klebsiella oxytoca, Proteus vulgaris, and nontyphoidal Salmonella spp. were 0.25, 1.0, and 0.12 mg/L, respectively, while those for other Gram-negative bacilli were 4-64 mg/L. In conclusion, gemifloxacin was the most active among the comparative agents against Gram-positive species, including respiratory pathogens isolated in Korea.
MeSH Terms
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Anti-Infective Agents/*therapeutic use
*Aza Compounds
Bacteria/*drug effects
Ciprofloxacin/therapeutic use
*Fluoroquinolones
Haemophilus influenzae/drug effects
Korea
Microbial Sensitivity Tests
Moraxella/drug effects
Naphthyridines/*therapeutic use
Ofloxacin/therapeutic use
*Quinolines
Streptococcus pneumoniae/drug effects
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