Immune Netw.  2014 Apr;14(2):107-115. 10.4110/in.2014.14.2.107.

Phellinus linteus Extract Exerts Anti-asthmatic Effects by Suppressing NF-kappaB and p38 MAPK Activity in an OVA-induced Mouse Model of Asthma

Affiliations
  • 1Department of Anatomy and Histology and Embryology, Yanbian University School of Basic Medical Sciences, YanJi 133002, Jilin, China.
  • 2Department of Anatomy, Medical School, Institute for Medical Sciences, Chonbuk National University, Jeonju 561-180, Korea. why76@jbnu.ac.kr

Abstract

Phellinus linteus has been used as a traditional herbal medicine in Asian countries and is known to have anti-tumor, immunomodulatory, anti-inflammatory, and anti-allergic activities. However, the protective effects of P. linteus against experimental asthma have not been fully investigated. The objective of this study was to determine whether P. linteus ethanol extract (PLE) suppresses inflammatory response in an OVA-induced asthma model. As expected, the oral administration of PLE significantly inhibited eosinophilic airway inflammation and airway hyperresponsiveness in OVA-challenged BALB/c mice. Supporting these data, the augmentation of Th2 cytokines (IL-4, IL-5, and IL-13), eotaxin, and adhesion molecules in lung tissues and bronchoalveolar lavage fluid after OVA inhalation was markedly attenuated by PLE. Furthermore, PLE reduced OVA-induced activation of NF-kappaB and p38 MAPK in lung tissues. Therefore, our results suggest the potential of P. linteus as a therapeutic agent for asthma.

Keyword

Phellinus linteus; Asthma; Allergic inflammation; Th2 cytokine; NF-kappaB; p38

MeSH Terms

Administration, Oral
Animals
Asian Continental Ancestry Group
Asthma*
Bronchoalveolar Lavage Fluid
Cytokines
Eosinophils
Ethanol
Herbal Medicine
Humans
Inflammation
Inhalation
Interleukin-5
Lung
Mice*
NF-kappa B*
Ovum
p38 Mitogen-Activated Protein Kinases*
Cytokines
Ethanol
Interleukin-5
NF-kappa B
p38 Mitogen-Activated Protein Kinases
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