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Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma

Jung JW, Park HS, Park CS, Cho SH, Choi IS, Moon HB, Kwon SS, Yoon HJ, Park JW, Lee JM, Choi DC, Choi BW

Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma. Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement...
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4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice

Lee JH, Im DS

Free fatty acid receptor 2 (FFA2, also known as GPR43), a G-protein-coupled receptor, has been known to recognize short-chain fatty acids and regulate inflammatory responses. FFA2 gene deficiency exacerbated disease...
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Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

Piao CH, Fan YJ, Nguyen TV, Yu ZN, Shin HS, Song CH, Chai OH

Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi...
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Dexmedetomidine as an adjunctive treatment for acute asthma

Motamed H, Forouzan A, Moezzi M, Alizadeh H

Objective This study aimed to compare the efficacy of using dexmedetomidine with salbutamol and salbutamol nebulization alone in patients with acute exacerbation of asthma presenting to the emergency department. Methods This...
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The Role of Upper Airway Microbiome in the Development of Adult Asthma

Losol P, Choi JP, Kim SH, Chang YS

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper...
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Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies

PARK RM

Background Toluene diisocyanate (TDI) is a highly reactive chemical that causes sensitization and has also been associated with increased lung cancer. A risk assessment was conducted based on occupational epidemiologic estimates...
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Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014

Woo H, Samra MS, Lim DH, Kim JH

Background: Most epidemiological studies depend on the subjects' response to asthma symptom questionnaires. Questionnaire-based study for childhood asthma prevalence may overestimate the true prevalence. The aim of this study was...
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MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway

Hur J, Rhee CK, Lee SY, Kim YK, Kang JY

Background/Aims: Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling...
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Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma

Kim YH, Jang YY, Jeong J, Chung HL

Background: Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose: We aimed to investigate the factors associated with BHR in adolescents with childhood...
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Age Differences in Pet Sensitization by Pet Ownership

Won JY, Kwon JW, Hong SN, Lee WH

Objectives. The association between pet sensitization and pet ownership remains unclear. Therefore, we aimed to elucidate the association between pet sensitization and pet ownership by age. Methods. We retrospectively reviewed 2,883...
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The Influence of COVID-19 on Asthma and Allergic Rhinitis

Kim YH

As the coronavirus disease 2019 (COVID-19) pandemic continues, doctors face many difficulties in managing patients with respiratory allergies. As research continues, much new knowledge has emerged about the link between...
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Therapeutic effect of atorvastatin on interleukin-13-induced lung pathology

Mo Y, Bae B, Kim J, Kim RL, Son K, Kang MJ, Lee CG, Cho SH, Kang HR

Purpose: Asthma is a common chronic lung disease, in which interleukin (IL)-13 is implicated as a central regulator of IgE synthesis, mucus hypersecretion, airway hyperresponsiveness (AHR), and fibrosis. This study...
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Efficacy and safety of mepolizumab in Korean patients with severe eosinophilic asthma from the DREAM and MENSA studies

Kim MK, Park HS, Park CS, Min SJ, Albers FC, Yancey SW, Mayer B, Kwon N

Background/Aims: The efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated in a global clinical trial programme. This post hoc analysis assesses the efficacy and...
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The Temporal Hyper-Morbidity of Asthma and Attention Deficit Disorder: Implications for Interpretation Based on Comparison of Prospective and Cross-Sectional Population Samples

Chai PH, Chang S, Cawthorpe D

Objective The purpose of this study was to test the hypothesis that a significant temporal relationship exists between asthma and attention deficit hyperactivity disorder (ADHD). Methods The population dataset consisted of...
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Eosinophils and childhood asthma

Choi BS

Eosinophils are a type of granulocyte with eosinophilic granules in the cytoplasm that play an important role in allergic and parasitic diseases. Eosinophils are important in the pathogenesis of asthma,...
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Nonepisodic angioedema with eosinophilia: A case report of a Korean patient

Choi J, Park SY, Moon KT, Lee WM, Lee BH, Kim SH

Nonepisodic angioedema with eosinophilia (NEAE) is a rare disease characterized by nonrecurrent angioedema with eosinophilia and normal serum IgM levels occurring predominantly in an East Asian female population. A 49-year-old...
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Antiasthmatic effect of atorvastatin via modulation of macrophage activation

Mo Y, Bae B, Kim Y, Kang H, Lee HS, Cho SH, Kang HR

Purpose: Asthma is a chronic airway inflammatory disorder and is associated with macrophages. Statin, a well-known lipid-lowering agent, has recently been noted for its anti-inflammatory effect on macrophage. This study...
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Cell Autonomous Circadian Systems and Their Relation to Inflammation

Annamneedi VP, Park JW, Lee GS, Kang TJ

All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN)...
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Are Patients with Asthma and Chronic Obstructive Pulmonary Disease Preferred Targets of COVID-19?

Bouazza B, Hadj-Said D, Pescatore KA, Chahed R

The coronavirus pandemic, known as coronavirus disease 2019 (COVID-19), is an infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus first identified in patients...
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Comparing Inhaler Use Technique Based on Inhaler Type in Elderly Patients with Respiratory Disease

Lee HY, Song JH, Won HK, Park Y, Chung KB, Lim HJ, Ahn YM, Lee BJ

Background: The aim of this study was to investigate inhaler device handling in elderly patients. Inhaler devices with respect to misuse and error correction were also compared. Methods: Inhaler use technique...
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