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Role of NEAT1/MiR-9-5p/SLC26A2 Pathway on Human Airway Smooth Muscle Cell

Wang X, Xu R, Chi D, Dai C, Sheng M

Purpose: Asthma is a serious inflammatory disease of the respiratory system in which airway smooth muscle cells (ASMCs) play a key role. This study aimed to investigate the expression of...
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Establishment of particulate matterinduced lung injury model in mouse

Park SY, An KS, Lee B, Kang JH, Jung HJ, Kim MW, Ryu HY, Shim KS, Nam KT, Yoon YS, Oh SH

Background: Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for...
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Patterns of medical care utilization according to environmental factors in asthma and chronic obstructive pulmonary disease patients

Jo EJ, Choi MH, Kim CH, Won KM, Kim YK, Jeong JH, An HY, Hwang MK, Park HK

Background/Aims: Weather and air pollution are associated with the exacerbation of respiratory diseases. We investigated patterns of medical care use according to meteorological factors and air pollution in patients with...
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Suppressive Effect of CYM50358 S1P4 Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice

Jeon WJ, Chung KW, Lee JH, Im DS

Levels of sphingosine 1-phosphate (S1P), an intercellular signaling molecule, reportedly increase in the bronchoalveolar lavage fluids of patients with asthma. Although the type 4 S1P receptor, S1P4 has been detected...
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Relationship between Thoracic Kyphosis and Selected Cardiopulmonary Parameters and Respiratory Symptoms of Patients with Chronic Obstructive Pulmonary Disease and Asthma

Aweto HA, Adodo RI

Background: Patients with advanced asthma and chronic obstructive pulmonary disease (COPD) have postural deviations such as thoracic hyperkyphosis, forward shoulder posture (FSP) due to an increase in head and cervical...
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Indoleamine 2,3-Dioxygenase in Hematopoietic Stem Cell-Derived Cells Suppresses Rhinovirus-Induced Neutrophilic Airway Inflammation by Regulating Th1- and Th17-Type Responses

Hossain FMA, Park SO, Kim HJ, Eo JC, Choi JY, Tanveer M, Uyangaa E, Kim K, Eo SK

Asthma exacerbations are a major cause of intractable morbidity, increases in health care costs, and a greater progressive loss of lung function. Asthma exacerbations are most commonly triggered by respiratory...
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Interactions between NCR + ILC3s and the Microbiome in the Airways Shape Asthma Severity

Ham J, Kim J, Choi S, Park J, Baek Mg, Kim YC, Sohn KH, Cho SH, Yang S, Bae YS, Chung DH, Won S, Yi H, Kang HR, Kim HY

Asthma is a heterogeneous disease whose development is shaped by a variety of environmental and genetic factors. While several recent studies suggest that microbial dysbiosis in the gut may promote...
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Association between Parental Cotinineverified Smoking Status and Childhood Asthma: a Population-based Nationally Representative Analysis

Jung J, Park HJ, Jung M

Background: Environmental tobacco smoke exposure due to parents is a modifiable risk factor for childhood asthma, but many studies have evaluated parental smoking using selfreported data. Therefore, we aimed to...
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Influence of age at complementary food introduction on the development of asthma and atopic dermatitis in Korean children aged 1–3 years

Lee J, Shin M, Lee B

Background: Complementary food in infancy is necessary for human growth, neurodevelopment, and health. However, the role of allergen consumption in early infancy and its effects on the development of food...
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A study on depression among adolescents with asthma in South Korea using the 15th Korea Youth Risk Behaviour Web-Based Survey

Park JH, Kim MJ

Purpose: This study investigated the factors that influence depression in adolescents diagnosed with asthma in South Korea, providing basic data supporting efforts to improve adolescents' mental health. Methods: Multiple regression analysis...
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Analysis of PC20-FEF25%-75% and △FVC in the methacholine bronchial provocation test

Kim HA, Kwon JE, Ahn JY, Choe JY, Kim DS, Park SH, Hyun MC, Choi BS

Purpose: Forced expiratory flow between 25% and 75% (FEF 25%-75%) is known to sensitively reflect bronchial obstruction. Methacholine challenge test (MCT) has shown varying reduction levels of forced vital capacity...
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Effect of omalizumab as add-on therapy to Quality of Life Questionnaire for Korean Asthmatics (KAQLQ) in Korean patients with severe persistent allergic asthma

Jung JW, Park HS, Park CS, Cho SH, Choi IS, Moon HB, Kwon SS, Yoon HJ, Park JW, Lee JM, Choi DC, Choi BW

Background/Aims: Omalizumab is the first biologic known to be effective in patients with severe allergic asthma. Methods: This study was conducted as a multicenter, single-group, open trial to evaluate the improvement...
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4-CMTB Ameliorates Ovalbumin-Induced Allergic Asthma through FFA2 Activation in Mice

Lee JH, Im DS

Free fatty acid receptor 2 (FFA2, also known as GPR43), a G-protein-coupled receptor, has been known to recognize short-chain fatty acids and regulate inflammatory responses. FFA2 gene deficiency exacerbated disease...
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Anti-allergic Effect of Fructus amomi on Ovalbumin-induced Asthma Mice Model

Piao CH, Fan YJ, Nguyen TV, Yu ZN, Shin HS, Song CH, Chai OH

Despite studies on the anti-inflammatory effect of Fructus amomi, mature fruit of Amomum villosum Lour, have been getting increasing extensively, it remains unknown about the detailed effects of F. amomi...
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Dexmedetomidine as an adjunctive treatment for acute asthma

Motamed H, Forouzan A, Moezzi M, Alizadeh H

Objective This study aimed to compare the efficacy of using dexmedetomidine with salbutamol and salbutamol nebulization alone in patients with acute exacerbation of asthma presenting to the emergency department. Methods This...
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The Role of Upper Airway Microbiome in the Development of Adult Asthma

Losol P, Choi JP, Kim SH, Chang YS

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper...
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Risk Assessment for Toluene Diisocyanate and Respiratory Disease Human Studies

PARK RM

Background Toluene diisocyanate (TDI) is a highly reactive chemical that causes sensitization and has also been associated with increased lung cancer. A risk assessment was conducted based on occupational epidemiologic estimates...
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Current Asthma Prevalence Using Methacholine Challenge Test in Korean Children from 2010 to 2014

Woo H, Samra MS, Lim DH, Kim JH

Background: Most epidemiological studies depend on the subjects' response to asthma symptom questionnaires. Questionnaire-based study for childhood asthma prevalence may overestimate the true prevalence. The aim of this study was...
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MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway

Hur J, Rhee CK, Lee SY, Kim YK, Kang JY

Background/Aims: Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling...
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Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma

Kim YH, Jang YY, Jeong J, Chung HL

Background: Bronchial hyperresponsiveness (BHR), an important physiological feature of asthma, is a prognostic marker of childhood asthma. Purpose: We aimed to investigate the factors associated with BHR in adolescents with childhood...
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