Immune Netw.  2014 Apr;14(2):81-88. 10.4110/in.2014.14.2.81.

Preclinical Efficacy and Mechanisms of Mesenchymal Stem Cells in Animal Models of Autoimmune Diseases

• Lee HK
• Lim SH
• Chung IS
• Park Y
• Park MJ
• Kim JY
• Kim YG
• Hong JT
• Kim Y
• Han SB

• KMID: 2168018
• DOI: http://doi.org/10.4110/in.2014.14.2.81

Abstract

Mesenchymal stem cells (MSCs) are present in diverse tissues and organs, including bone marrow, umbilical cord, adipose tissue, and placenta. MSCs can expand easily in vitro and have regenerative stem cell properties and potent immunoregulatory activity. They inhibit the functions of dendritic cells, B cells, and T cells, but enhance those of regulatory T cells by producing immunoregulatory molecules such as transforming growth factor-beta, hepatic growth factors, prostaglandin E2, interleukin-10, indolamine 2,3-dioxygenase, nitric oxide, heme oxygenase-1, and human leukocyte antigen-G. These properties make MSCs promising therapeutic candidates for the treatment of autoimmune diseases. Here, we review the preclinical studies of MSCs in animal models for systemic lupus erythematosus, rheumatoid arthritis, Crohn's disease, and experimental autoimmune encephalomyelitis, and summarize the underlying immunoregulatory mechanisms.

Keyword

Mesenchymal stem cells; Immunoregulation; Autoimmune diseases

MeSH Terms

Adipose Tissue
Arthritis, Rheumatoid
Autoimmune Diseases*
B-Lymphocytes
Bone Marrow
Crohn Disease
Dendritic Cells
Dinoprostone
Encephalomyelitis, Autoimmune, Experimental
Heme Oxygenase-1
Humans
Intercellular Signaling Peptides and Proteins
Interleukin-10
Leukocytes
Lupus Erythematosus, Systemic
Mesenchymal Stromal Cells*
Models, Animal*
Nitric Oxide
Placenta
Stem Cells
T-Lymphocytes
T-Lymphocytes, Regulatory
Umbilical Cord
Dinoprostone
Heme Oxygenase-1
Intercellular Signaling Peptides and Proteins
Interleukin-10
Nitric Oxide

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