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Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies

Jeong JH, Lee SY, Han HS, Kim JH, Sung IK, Park HS

Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with...
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Varicella zoster virus (VZV)-specific immunity and subclinical VZV reactivation in patients with autoimmune diseases

Lee KH, Choi S, Kwon JS, Kim SH, Park SY

Background/Aims: The risk of herpes zoster (HZ) is increased in patients with autoimmune diseases (AID), probably due to immunosuppressive therapy. Methods: This prospective cross-sectional study investigated varicella zoster virus (VZV)-specific immunity...
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Recent advances in the diagnosis and management of interstitial pneumonia with autoimmune features: the perspective of rheumatologists

Min HK, Kim SH, Lee SH, Kim HR

Interstitial pneumonia with autoimmune feature (IPAF) is a recently established disease entity that is comprised of interstitial lung diseases with evidence of autoimmune features but that does not fulfill the...
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Current advances in the treatment of autoimmune-associated interstitial lung diseases

Lee S, Lee JH

Autoimmune-associated interstitial lung disease (ILD) is a widespread and clinically significant form of autoimmune diseases. ILD can be present in most type of autoimmune diseases. Scleroderma, Sjogren syndrome, rheumatoid arthritis,...
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Biologic therapies for the treatment of systemic lupus erythematosus

Park SH

Systemic lupus erythematosus is a typical autoimmune disease with a complex etiology, including the interaction of genetic/epigenetic factors and environmental and hormonal factors with innate immune cells or B/T lymphocytes....
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Immunoglobulin G4-Related Disease of the Ovary Mimicking Bilateral Ovarian Malignancies

Sim Y, Chung T, Jung DC, Kim HS, Oh YT

Immunoglobulin G4-related disease (IgG4-RD) is a fibro-inflammatory condition characterized by several pathological features that can theoretically involve all organs. Ovarian involvement in IgG4-RD has been reported by two studies only....
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Gastric IgG4-related disease presenting as a mass lesion and masquerading as a gastrointestinal stromal tumor

Ramakrishna B, Yewale R, Vijayakumar K, Radhakrishna P, Ramakrishna BS

IgG4-related disease of the stomach is a rare disorder, and only a few cases have been reported. We present two cases that were identified over a 2-month period in our...
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Histone Deacetylase 9: Its Role in the Pathogenesis of Diabetes and Other Chronic Diseases

Hu S, Cho EH, Lee JY

As a member of the class IIa histone deacetylases (HDACs), HDAC9 catalyzes the deacetylation of histones and transcription factors, commonly leading to the suppression of gene transcription. The activity of...
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Report of the Korean Association of ExternalQuality Assessment Service on AutoimmuneTesting (2018–2019)

Chung HJ, Moon HW, Yi J

Under the Korean Association of External Quality Assessment Service,autoimmune proficiency testings (PT) for six test items were performed in2018–2019 for laboratory quality improvement. We conducted two trials peryear and sent...
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Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Ace Card to Address Autoimmune Diseases

Baharlooi , Azimi M, Salehi Z, Izad M

With the development of novel treatments for autoimmune disorders, it has become a popular research focus which mesenchymal stem cells (MSCs) have the capacity to counteract with autoimmune diseases progression....
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Helicobacter pylori and Immune-mediated Disorders

Park JY

Recently, many studies have reported the potential association of Helicobacter pylori (H. pylori) with various extragastric diseases. H. pylori, a major component of the gastric microbiota, is in symbiosis with...
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Mutation of ten-eleven translocation-2 is associated with increased risk of autoimmune disease in patients with myelodysplastic syndrome

Oh YJ, Shin DY, Hwang SM, Kim SM, Im K, Park HS, Kim JA, Song YW, Márquez A, Martín J, Lee DS, Park JK

Background/Aims: Myelodysplastic syndrome (MDS) is caused by genetic and epigenetic alteration of hematopoietic precursors and immune dysregulation. Approximately 20% of patients with MDS develop an autoimmune disease (AID). Here, we...
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Diffuse Systemic Sclerosis in a Patient with Primary Biliary Cirrhosis and Autoimmune Hepatitis Overlap Syndrome: A Case Report

Han HS, Ahn GR, Kim HJ, Park KY, Li K, Seo SJ

Systemic sclerosis (SSc) is a chronic systemic disease of unknown etiology characterized by vasculopathy, excessive accumulation of extracellular matrix, and fibrosis of the skin and other internal organs. Although its...
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Induction of anti-aquaporin 5 autoantibodies by molecular mimicry in mice

Lee A, Choi Y

Molecular mimicry is the most common mechanism that breaches self-tolerance. We previously identified autoantibodies to aquaporin-5 (AQP5) in the sera of patients with Sjögren’s syndrome and found that the aquaporin...
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Pathogenesis of vitiligo

Seok SH, Kim DH

Vitiligo is an autoimmune disease in which CD8+ T-cells target and destroy melanocytes, leaving areas of skin without pigment production. Nonsegmental vitiligo, the classical form of the disease, results in...
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Crosstalk between the Producers and Immune Targets of IL-9

Do-Thi VA, Lee JO, Lee H, Kim YS

IL-9 has been reported to play dual roles in the pathogenesis of autoimmune disorders and cancers. The collaboration of IL-9 with microenvironmental factors including the broader cytokine milieu and other...
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Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus

Li Y, Zhou Y, Zhao M, Zou J, Zhu Y, Yuan X, Liu Q, Cai H, Chu CQ, Liu Y

Background No currently available biomarkers or treatment regimens fully meet therapeutic needs of type 1 diabetes mellitus (T1DM). Circular RNA (circRNA) is a recently identified class of stable noncoding RNA that...
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Clinical Relevance for Serum Cold-Inducible RNA-Binding Protein Level in Alopecia Areata

Shin JM, Ko JW, Kwon IS, Choi JW, Hong D, Lee JH, Seo YJ, Kim CD, Lee JH, Lee Y, Park KD

BACKGROUND: Alopecia areata (AA), a chronic, relapsing hair-loss disorder, is considered to be a T-cell-mediated autoimmune disease. Cold-inducible RNA-binding protein (CIRP) belongs to a family of cold-shock proteins that respond...
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A Novel Immunomodulatory Mechanism Dependent on Acetylcholine Secreted by Human Bone Marrow-derived Mesenchymal Stem Cells

Yi TG, Cho YK, Lee HJ, Kim J, Jeon MS, Ham DS, Kim WC, Song SU

BACKGROUND AND OBJECTIVES: Mesenchymal stem cells (MSCs) are used to treat autoimmune or inflammatory diseases. Our aim was to determine the immunomodulatory mechanisms elicited by MSCs during inflammation. METHODS AND RESULTS:...
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Autoimmune Diseases and Gastric Cancer Risk: A Systematic Review and Meta-Analysis

Song M, Latorre G, Ivanovic-Zuvic D, Camargo MC, Rabkin CS

PURPOSE: Autoimmunity is an alternative etiology of gastric inflammation, the initiating event in the gastric carcinogenic cascade. This mechanism may be an increasingly important cause of gastric cancer with the...
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