Hanyang Med Rev.  2015 May;35(2):84-91. 10.7599/hmr.2015.35.2.84.

Noise-Induced Hearing Loss

Affiliations
  • 1Department of Otolaryngology, Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea. eardoc11@naver.com

Abstract

Noise-induced hearing loss (NIHL) is the second most common cause of permanent hearing impairment after age-related hearing loss. NIHL is influenced by environmental and genetic factors and the effects of noise can be exacerbated by the administration of ototoxic drugs or exposure to chemicals. The pathophysiology of NIHL is classified as either mechanical injury or metabolic (or biochemical) injury. Exposure of cochleae to intense sounds has been found to disrupt the stereocilia on the hair cells by separating the tip links and to depolymerize actin filaments, resulting in a disturbance in signal transduction. Major mechanisms of metabolic injuries include accumulation of reactive oxygen species enhanced by oxidative stress, cochlear ischemia followed by reperfusion injury, and excitotoxicity to auditory neuron induced by excessive release of the cochlear afferent neurotransmitter, glutamate. Many studies involving therapeutic or preventive trial with antioxidants, JNK inhibitors, and NMDA antagonists have shown partial effectiveness. However, protection from noise before cochlear injury occurs is very important because damaged hair cells and auditory neurons in the mammalian cochleae are unable to regenerate.

Keyword

Hearing Loss, Noise-Induced; Cochlea; Hair Cells, Auditory; Oxidative Stress; Apoptosis

MeSH Terms

Actin Cytoskeleton
Antioxidants
Apoptosis
Cochlea
Glutamic Acid
Hair
Hair Cells, Auditory
Hearing Loss
Hearing Loss, Noise-Induced*
Ischemia
N-Methylaspartate
Neurons
Neurotransmitter Agents
Noise
Oxidative Stress
Reactive Oxygen Species
Reperfusion Injury
Signal Transduction
Stereocilia
Antioxidants
Glutamic Acid
N-Methylaspartate
Neurotransmitter Agents
Reactive Oxygen Species

Figure

  • Fig. 1 Stress-activated MAPK signaling modules. The JNK and p38 MAPK are activated by dual phosphorylation on Thr and Tyr caused by members of the MAPKK group of protein kinases. The MAPKK are activated, in turn, by phosphorylation mediated by a group of MAPKKK. Stress-activated MAPK signaling modules can be created through the sequential actions of a MAPKKK, a MAPKK, and a MAPK. Ref. 30 with permission from Cell Press.

  • Fig. 2 Role of the JNK signaling pathway in stress-induced apoptosis. The caspase apoptotic machinery is illustrated in a simplified cartoon. Effector caspases, including caspase-3, are activated by initiator caspases that are activated by cell surface death receptors (caspase-8) and by the mitochondrial pathway (caspase-9). JNK is not required for death receptor signaling, but is required for caspase-9 activation by the mitochondrial pathway. Potential targets of JNK include members of the Bcl2 group of apoptotic regulatory proteins. Ref. 30 with permission from Cell Press.


Cited by  2 articles

The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
Dae Yun Kim, A Ram Kim, Joo Hyun Sung, Choong Ryeol Lee, Jiho Lee
Ann Occup Environ Med. 2019;31(1):.    doi: 10.35371/aoem.2019.31.e11.

Etiology and Rehabilitation of Sensorineural Hearing Loss
Seung Hwan Lee
Hanyang Med Rev. 2015;35(2):55-56.    doi: 10.7599/hmr.2015.35.2.55.


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