- Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?
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Park YH
- KMID: 2052083
- J Audiol Otol.
- 2015 Sep;19(2):63-67.
- doi: 10.7874/jao.2015.19.2.63
In mammals, the auditory system, which includes the cochlea, has a very complex structure harboring many types of cells performing different functions. Among these cells are the auditory hair cells... -
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- Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
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Lee S, Jeong HS, Cho HH
- KMID: 2367338
- Chonnam Med J.
- 2017 Jan;53(1):37-46.
- doi: 10.4068/cmj.2017.53.1.37
Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement... -
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- Noise-Induced Hearing Loss
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Shim HJ
- KMID: 1793736
- Hanyang Med Rev.
- 2015 May;35(2):84-91.
- doi: 10.7599/hmr.2015.35.2.84
Noise-induced hearing loss (NIHL) is the second most common cause of permanent hearing impairment after age-related hearing loss. NIHL is influenced by environmental and genetic factors and the effects of... -
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- Different uptake of gentamicin through TRPV1 and TRPV4 channels determines cochlear hair cell vulnerability
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Lee JH, Park C, Kim SJ, Kim HJ, Oh GS, Shen A, So HS, Park R
- KMID: 2154231
- Exp Mol Med.
- 2013 Mar;45(3):e12.
Hair cells at the base of the cochlea appear to be more susceptible to damage by the aminoglycoside gentamicin than those at the apex. However, the mechanism of base-to-apex gradient... -
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- Over-expression of myosin7A in cochlear hair cells of circling mice
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Kim YY, Nam H, Jung H, Kim B, Suh JG
- KMID: 2375266
- Lab Anim Res.
- 2017 Mar;33(1):1-7.
- doi: 10.5625/lar.2017.33.1.1
Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerated... -
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- Changes of Cochlear Nerve Terminals after Temporary Noise-Induced Hearing Loss
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Seo JK, Lim HW, Park HJ, Pak JH, Chung JW
- KMID: 1426497
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2013 Apr;56(4):206-211.
- doi: 10.3342/kjorl-hns.2013.56.4.206
BACKGROUND AND OBJECTIVES: Overexposure to intense sound can cause temporary or permanent hearing loss. Post-exposure recovery of thresholds has been assumed to indicate reversal of damage to the inner ear... -
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- Neural Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells: Applicability for Inner Ear Therapy
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Lee JH, Kang WK, Seo JH, Choi MY, Lee YH, Kim HM, Park KH
- KMID: 1828452
- Korean J Audiol.
- 2012 Sep;16(2):47-53.
- doi: 10.7874/kja.2012.16.2.47
BACKGROUND AND OBJECTIVES: Regeneration or replacement of damaged hair cells and neurons in the cochlea might be an ideal treatment for sensorineural hearing loss (SNHL). The purpose of the present... -
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- Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application
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Woods O, Saliba I
- KMID: 2415946
- J Audiol Otol.
- 2018 Apr;22(2):75-79.
- doi: 10.7874/jao.2017.00199
BACKGROUND AND OBJECTIVES: Locacorten Vioform (Novartis UK) is frequently prescribed for otomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, its ototoxic potential has not been evaluated.... -
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- Apoptosis Progression in the Hair Cells in the Organ of Corti of GJB2 Conditional Knockout Mice
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Zhang Y, Zhang X, Li L, Sun Y, Sun J
- KMID: 2134595
- Clin Exp Otorhinolaryngol.
- 2012 Sep;5(3):132-138.
- doi: 10.3342/ceo.2012.5.3.132
OBJECTIVES: Apoptosis may play an important role in the mechanism underlying the GJB2 gene conditional knockout (cCx26) mice cochlear cell death. The objective of this study was to explore the... -
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- Immunohistochemical Expressions of TrkB and TrkC Receptors in Rat Cochleas with Amikacin-induced Ototoxicity
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Park SY, Chae SY
- KMID: 2274515
- Korean J Otolaryngol-Head Neck Surg.
- 1998 Dec;41(12):1507-1512.
BACKGROUND AND OBJECTIVES: Neurotrophins have been known to be responsible for the differentiation and survival of developing neurons as well as for aiding the recovery of adult neurons from injury.... -
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- Valuation of Transient Evoked Otoacoustic Emissions and Distortion Product Otoacoustic Emissions in Tinnitus Patients with Normal Hearing
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Kim JT, Lee HS, Lee HR, Choi HS, Lee BD, Hwang K
- KMID: 2368010
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2016 Dec;59(12):831-835.
- doi: 10.3342/kjorl-hns.2016.59.12.831
BACKGROUND AND OBJECTIVES: This study aims to verify that one of the causes of tinnitus is the malfunction of outer hair cells and, on the basis of this, to investigate... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Protective Effect of Metformin on Gentamicin-Induced Vestibulotoxicity in Rat Primary Cell Culture
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Lee JY, Lee SH, Chang JW, Song JJ, Jung HH, Im GJ
- KMID: 2278369
- Clin Exp Otorhinolaryngol.
- 2014 Dec;7(4):286-294.
- doi: 10.3342/ceo.2014.7.4.286
OBJECTIVES: One of the antidiabetic drugs, metformin, have shown that it prevented oxidative stress-induced death in several cell types through a mechanism involving the opening of the permeability transition pore... -
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- Inhibition of K⺠outward currents by linopirdine in the cochlear outer hair cells of circling mice within the first postnatal week
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Kang SW, Ahn JW, Ahn SC
- KMID: 2371044
- Korean J Physiol Pharmacol.
- 2017 Mar;21(2):251-257.
- doi: 10.4196/kjpp.2017.21.2.251
Inhibition of K⺠outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using... -
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- ROS Scavenger, Ebselen, Has No Preventive Effect in New Hearing Loss Model Using a Cholesterol-Chelating Agent
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Lee MY, Kabara LL, Swiderski , Raphael Y, Duncan RK, Kim YH
- KMID: 2447576
- J Audiol Otol.
- 2019 Apr;23(2):69-75.
- doi: 10.7874/jao.2018.00255
BACKGROUND AND OBJECTIVES: The antioxidant ebselen will be able to limit or prevent the ototoxicity arising from 2-hydroxypropyl-β-cyclodextrin (HPβCD). Niemann-Pick Type C (NPC) disease is a disorder of lysosomal storage... -
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- Hearing Improvement in A/J Mice via the Mouse Nerve Growth Factor
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Gao L, Ge R, Xie G, Yao D, Li P, Wang O, Ma X, Han F
- KMID: 2396783
- Clin Exp Otorhinolaryngol.
- 2017 Dec;10(4):303-308.
- doi: 10.21053/ceo.2016.01354
OBJECTIVES: To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. METHODS: The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group... -
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- Differential Expression of Ca²âº-buffering Protein Calretinin in Cochlear Afferent Fibers: A Possible Link to Vulnerability to Traumatic Noise
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Sharma K, Seo YW, Yi E
- KMID: 2424734
- Exp Neurobiol.
- 2018 Oct;27(5):397-407.
- doi: 10.5607/en.2018.27.5.397
The synaptic contacts of cochlear afferent fibers (CAFs) with inner hair cells (IHCs) are spatially segregated according to their firing properties. CAFs also exhibit spatially segregated vulnerabilities to noise. The... -
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- The Objective Test of Cochlear Dead Region Using Acoustic Change Complex: A Preliminary Report
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Kang S, Han J, Woo J, Park HS, Moon IJ, Choi K, Hong SH
- KMID: 2436551
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2018 Nov;61(11):573-579.
- doi: 10.3342/kjorl-hns.2017.00976
BACKGROUND AND OBJECTIVES: Cochlear dead region (CDR) is a region in the cochlear where hearing loss has occurred due to damage to the inner hair cells and/or neurons. Recently, a... -
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