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Potential Implications of Slim Modiolar Electrodes for Severely Malformed Cochleae: A Comparison With the Straight Array With Circumferential Electrodes

Lee SY, Choi BY

Objectives. Malformations of the inner ear account for approximately 20% of cases of congenital deafness. In current practice, straight arrays with circumferential electrodes (i.e., full-banded electrodes) are widely used in...
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Three-Dimensional Distribution of Cochlear Macrophages in the Lateral Wall of Cleared Cochlea

Bae SH, Kwak SH, Yoo JE, Kim KM, Hyun YM, Choi JY, Jung J

Objectives. Resident macrophages are well known to be present in the cochlea, but the exact patterns thereof in spiral ligaments have not been discussed in previous studies. We sought to...
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Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

Oh SJ, Lee IW, Wang SG, Kong SK, Kim HK, Goh EK

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be...
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Distribution of Kv3 Subunits in Cochlear Afferent and Efferent Nerve Fibers Implies Distinct Role in Auditory Processing

Kim WB, Kang KW, Sharma K, Yi Ey

  • KMID: 2508471
  • Exp Neurobiol.
  • 2020 Oct;29(5):344-355.
  • doi: 10.5607/en20043
Kv3family K + channels, by ensuring speedy repolarization of action potential, enable rapid and high frequency neuronal firing and high precision temporal coding of auditory information in various auditory synapses...
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Cochlear Damage Caused by the Striking Noise of Titanium Head Golf Driver

Park YH, Chung J, Lee MY, Lee DY, Kim YH

OBJECTIVES.: To investigate how mouse cochleae are affected by the striking noise of titanium head golf driver. METHODS.: Thirty-two BALB/c mice (20–22 g) with normal hearing were used. The impact acoustic...
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Comparison of Temporal Bone Parameters before Cochlear Implantation in Patients with and without Facial Nerve Stimulation

Kasetty VM, Zimmerman , King S, Seyyedi M

BACKGROUND AND OBJECTIVES: Facial nerve stimulation (FNS) is a complication of cochlear implantation (CI). This study compared the thickness and density of the bone separating the upper basal turn of...
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Limitation of High Pitch Sound Perception in Nontumor Patients with Auditory Brainstem Implantation

Choi HS, Choi JY, Moon IS, Bae MR, Kim BG, Kim M, Chang JW, Jeong J

BACKGROUND AND OBJECTIVES: Auditory brainstem implantation (ABI) is another option for hearing rehabilitation in non-neurofibromatosis type 2 patients who cannot undergo cochlear implantation (CI). However, the average performance of ABI...
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The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1

Chang MY, Rhee J, Kim SH, Kim YH

OBJECTIVES: Local administration of 3-nitropropionic acid (3-NP) to the inner ear induces sensorineural hearing loss. Several studies have shown the otoprotective effects of ginkgo biloba extract EGb 761. Moreover, EGb...
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The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro

Moon BS, Ammothumkandy A, Zhang N, Peng L, Ibrayeva A, Bay M, Pratap A, Park HJ, Bonaguidi , Lu W

OBJECTIVES: Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown....
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A Case of Scala Vestibuli Cochlear Implantation in Tympanogenic Labyrinthitis Ossificans

Lee YS, Heo JH, Park YH, Choi JW

Labyrinthitis ossificans (LO) is a pathologic formation of fibrosis and new bone within the lumen of the otic capsule. The LO is a challenging issue in cochlear implantation since obliteration...
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Functional Significance of Medial Olivocochlear System Morphology in the Mouse Cochlea

Park SY, Park JM, Back SA, Yeo SW, Park SN

OBJECTIVES: Baso-apical gradients exist in various cochlear structures including medial olivocochlear (MOC) efferent system. This study investigated the cochlear regional differentials in the function and morphology of the MOC system,...
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Over-expression of myosin7A in cochlear hair cells of circling mice

Kim YY, Nam H, Jung H, Kim B, Suh JG

Circling mouse (C57BL/6J-cir/cir) deleted the transmembrane inner ear (Tmie) gene is an animal model for human non-syndromic recessive deafness, DFNB6. In circling mouse, hair cells in the cochlea have degenerated...
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Two Cases of Electrode Kinking in Cochlear Implantation

Lim S, Kim H, Kim JH, Im GJ

Less traumatic electrode insertion along the basal turn of cochlea is essential to cochlear implantation. However, immoderate attempts to insert the electrode beyond the point of resistance can result in...
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Clinical Application of Hyperbaric Oxygen in Treatment of Idiopathic Sudden Sensorineural Hearing Loss

Kim SA, Ahn JH

Sudden sensorineural hearing loss is relatively common disease with unknown etiology. Although its etiology is unknown, it is thought to be a common pathway that leads to cochlear ischemia which...
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Outcomes of Severe to Profound Idiopathic Sudden Sensorineural Hearing Loss

Jo SY, Lee S, Eom TH, Jeun ES, Cho HH, Cho YB

OBJECTIVES: While a severe to profound sudden sensorineural hearing loss (SSNHL) may cause serious disability in verbal communication, there have been little studies focusing on this high degree SSNHL. The...
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Stem Cell Therapy for Sensorineural Hearing Loss, Still Alive?

Park YH

In mammals, the auditory system, which includes the cochlea, has a very complex structure harboring many types of cells performing different functions. Among these cells are the auditory hair cells...
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Auditory Rehabilitation - Cochlear Implantation

Lee JH

The first cochlear implant was approved about 30 years ago. It just provided a limited sensation of sound and facilitated lip-reading based communication. Recent advances in the cochlear implant system...
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Noise-Induced Hearing Loss

Shim HJ

Noise-induced hearing loss (NIHL) is the second most common cause of permanent hearing impairment after age-related hearing loss. NIHL is influenced by environmental and genetic factors and the effects of...
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Mass and Stiffness Impact on the Middle Ear and the Cochlear Partition

Kim J, Koo M

Mass and stiffness affect on the peculiar characteristics of transmission of the middle ear and the distinctive behavior of the cochlear mechanics. Applying the principle of the mass and stiffness,...
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Influences of Diabetes on Hearing Recovery in Noise-Exposed Mice

Yang CJ, Lee JW, Chung JW

BACKGROUND AND OBJECTIVES: Many studies have reported an association between diabetes and hearing loss. However, these reports were mainly abstractive correlations between common hearing loss and the incidence of diabetes....
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