Korean J Physiol Pharmacol.  2002 Dec;6(6):311-317.

Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

• Kim MJ
• Ryu GR
• Yi SY
• Min DS
• Rhie DJ
• Yoon SH
• Hahn SJ
• Kim MS
• Jo YH

Abstract

This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and the tissue content of amylase were significantly reduced in diabetic rats, while the output and the content of lipase were increased. Plasma secretin and cholecystokinin (CCK) concentrations of diabetic rats were significantly increased compared to those of normal rats. The altered pancreatic exocrine function was abolished by the exogenous insulin administration. The exogenous insulin also restored the increased plasma secretin and CCK concentrations. From the above results, it is suggested that, in streptozotocin-induced diabetic rats, anticoordinated changes in pancreatic enzymes secretion as well as pancreatic enzymes content are attributable to insulin deficiency and that the insulin deficiency is responsible for the increased plasma concentrations of both secretin and CCK. However, it is not clear whether the elevated plasma secretin and CCK concentrations played a direct role in changes of pancreatic exocrine function.

Keyword

Amylase; Lipase; Secretin; Cholecystokinin; Streptozotocin; Diabetes

MeSH Terms

Amylases
Animals
Cholecystokinin
Gastrointestinal Hormones*
Insulin
Lipase
Plasma
Rats*
Secretin
Streptozocin
Amylases
Cholecystokinin
Gastrointestinal Hormones
Insulin
Lipase
Secretin
Streptozocin