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Evaluation of Asymptomatic Hyperamylasemia and Hyperlipasemia

Lee SH

There are increasing number of cases of serum amylase and lipase levels being examined as part of health screening, but the clinical significance of these amylase and lipase levels is...
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Is Oxytocin Application for Autism Spectrum Disorder Evidence-Based?

Lee SY, Lee AR, Hwangbo R, Han J, Hong M, Bahn GH

Autism spectrum disorder (ASD) is characterized by persistent deficits within two core symptom domains: social communication and restricted, repetitive behaviors. Although numerous studies have reported psychopharmacological treatment outcomes for the...
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Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder

Lee YJ, Oh SH, Park C, Hong M, Lee AR, Yoo HJ, Shin CY, Cheon KA, Bahn GH

  • KMID: 2171125
  • Clin Psychopharmacol Neurosci.
  • 2014 Apr;12(1):19-30.
In clinical practice, pharmacological treatment is mostly focused on behavioral symptoms in everyday life. Nevertheless, persistent effort continues to develop medication for causal treatment. Recent changes in diagnostic criteria from...
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The Effect of Secretin on Pepsin Secretion in Heidenhain Pouch

Lee SH, Kim CB

  • KMID: 2096305
  • J Korean Surg Soc.
  • 2006 Mar;70(3):161-169.
PURPOSE: This research was done to confirm the effect of secretin on pepsin secretion and to study whether or not feeding can depress the secretin-stimulated pepsin secretion (SSPS) with its...
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Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG

  • KMID: 1105280
  • Exp Mol Med.
  • 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,...
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The Clinical Usefulness of Fecal Elastase-1 Test as an Exocrine Pancreatic Function Test for the Diagnosis of Chronic Pancreatitis

Lee SH, Choi HS

  • KMID: 1773023
  • Korean J Gastrointest Endosc.
  • 2004 Dec;29(6):500-508.
BACKGROUND/AIMS: The quantitative analysis of fecal elastase-1 has been proposed as a noninvasive test for the examination of pancreatic exocrine function. Therefore, we evaluated the diagnostic value of fecal elastase-1...
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Roles of Gonadal Steroids on Exocrine Secretion of Isolated Perfused Rat Pancreas

Park HS, Kim SH, Park HJ, Lee MY, Han YH

  • KMID: 2285290
  • Korean J Physiol Pharmacol.
  • 2003 Aug;7(4):217-222.
To clarify the roles of gonadal steroids on pancreatic exocrine secretion, effects of progesterone and estradiol-17beta on spontaneous and secretagogue-induced exocrine response of isolated perfused rat pancreas were investigated. Intra-arterial...
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Altered Secretory Pattern of Pancreatic Enzymes and Gastrointestinal Hormones in Streptozotocin-induced Diabetic Rats

Kim MJ, Ryu GR, Yi SY, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH

  • KMID: 1615198
  • Korean J Physiol Pharmacol.
  • 2002 Dec;6(6):311-317.
This study was performed to investigate the pancreatic exocrine dysfunction in streptozotocin- induced diabetic rats. Changes in pancreatic enzymes secretion and in pancreatic enzymes content were observed. The output and...
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Effects of gamma-Aminobutyric Acid on Pancreatic Amylase Secretion Evoked by Sodium Oleate in Anesthetized Rats

Park YD, Cui ZY, Park HS, Park HJ

  • KMID: 1614855
  • Korean J Physiol Pharmacol.
  • 2002 Feb;6(1):27-32.
gamma-Aminobutyric Acid (GABA) is contained in pancreatic islet beta-cells although its physiological role in pancreatic exocrine function is completely unknown at the present time. Recently, we have reported that exogenous...
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Effect of Acriflavine-Guanosine Compound (AG60) Treatment on the Gastrointestinal Endocrine Cells of Mouse Inoculated with Ehrlich Carcinoma Cells

Park KH, Song HG, Ko JS, Ahn ET, Kim JG

  • KMID: 1559151
  • Korean J Anat.
  • 2002 Feb;35(1):25-36.
To study the tumor-suppression effect of a newly developed anti-tumor agent AG60 [ acriflavine (1) : guanosine (1) composition, Taerim Pharm. Co., Seoul, Korea], each Ehrlich carcinoma (107 cells)-inoculated mouse...
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A Case of Metachronous Multiple Endocrine Neoplasia Type I Manifested as Zollinger-Ellison Syndrome

Lee YM, Jung HY, Choi SY, Kang HH, Myung SJ, Yang SK, Hong WS, Kim JH, Min YI

  • KMID: 1606511
  • Korean J Gastroenterol.
  • 2002 Jan;39(1):50-54.
Zollinger-Ellison syndrome (ZES) is characterized by recurrent peptic ulcer and diarrhea caused by gastric acid hypersecretion due to gastrinoma. Approximately, one third of patients with gastrinoma have multiple endocrine neoplasia...
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The Effect of Escherichia coli Lipopolysaccharide on the Flow of Bile in the Cat

Choi JW, Jung YS, Park JW, Jin H, Lim SW

  • KMID: 2244350
  • Korean J Hepatobiliary Pancreat Surg.
  • 2000 Oct;4(2):27-33.
Pathophysiological conditions such as sepsis and hepatitis are frequently associated with cholestasis. Cholestasis in patients with sepsis has been attributed to the effects of endotoxin(lipopholysaccharides, LPS) and LPS-induced cytokines(TNF-a, IL-6,...
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Usefulness of Intraductal Secretin Test in Assessing Exocrine Pancreatic Function in Patients with Chronic Pancreatitis

Choi HS, Cho YJ, Hahm JS, Han DS, Sohn JH, Jun YC, Yoon BC, Lee MH, Lee DH, Kee CS, Park KN, Park IG

  • KMID: 2014243
  • Korean J Gastrointest Endosc.
  • 2000 Sep;21(3):723-729.
BACKGROUND/AIMS: The duodenal intubation test (duodenal secretin test; DST) is now considered the 'gold standard' test of exocrine pancreatic function in detecting exocrine pancreatic dysfunction in patients with chronic pancreatitis....
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Serotonin and pancreatic duct function

Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko SB, Yoshikawa , Yamamoto A, Hamada H, Hayakawa T

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT...
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Effects of GABA on pancreatic exocrine secretion of rats

Park HS, Park HJ

Since GABA and its related enzymes had been determined in beta-cells of pancreas islets, effects of GABA on pancreatic exocrine secretion were investigated in the isolated perfused rat pancreas. GABA, given intra-arterially...
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The diagnostic value of serum and fecal pancreatic elastase-1 in patients with pancreatic disease

Kang CD, Kim KH, Lee HS, Kim CD, Lee JW, Hur BW, Jeen YT, Chun HJ, Song CW, Um SH, Lee SW, Choi JH, Ryu HS, Hyun JH

  • KMID: 2251313
  • Korean J Med.
  • 2000 Apr;58(4):392-401.
BACKGROUND: The aims of this study were to evaluate the diagnostic value of pancreatic elastase-1(PE-1) in patients with pancreatic diseases and compare the significance of PE-1 with that of pancreatic exocrine function...
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Pancreatic Exocrine Function according to Pancreatograms in Patients with Chronic Pancreatitis

Kim KH, Lee HS, Kim CD, Ryu HS, Hyun JH

  • KMID: 1548532
  • Korean J Gastroenterol.
  • 1999 Nov;34(5):667-673.
BACKGROUND/AIMS: This study was to evaluate the relationship between pancreatic exocrine functional impairment and degree of ductal change observed by endoscopic retrograde pancreatography (ERP) in patients with chronic pancreatitis (CP)....
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Mechanism of the Potentiating Effect of Secretin-CCK in Rat Pancreas

Lee DK, Kim JM, Kwon SO, Park KS, Chung JB, Kang JK, Kim KH

  • KMID: 2143777
  • Korean J Gastroenterol.
  • 1997 Mar;29(3):380-393.
BACKGROUND/AIMS: The rnechanism of secretin and CCK potentiation effect was evaluated in the dispersed pancreatic acini of rat. METHODS: To observe the presence of potentiating effect of secretin and insulin...
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The Role of Nitric Oxide on Pancreatic Exocrine Function in Resting and Secretin Stimulated State

Lee HS, Kim CD, Hyun JH

  • KMID: 2143776
  • Korean J Gastroenterol.
  • 1997 Mar;29(3):370-379.
BACKGROUND/AIMS: Recently NADPH-diaphorase has been detected in intrinsic neurons of the rat pancreas. So, nitric oxide(NO) should be considered as a putative neuronal mediator regulating pancreatic secretion(PS). We have investigated...
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The parathyroid hormone-2 receptor: Current status

Usdin TB

  • KMID: 2128620
  • Exp Mol Med.
  • 1997 Mar;29(1):13-17.
G-protein coupled receptors form a large superfamily of plasma membrane proteins which serve a variety of signal transduction roles. New receptors continue to be identified. Based on sequence homology the...
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