J Korean Med Sci.
2000 Aug;15(Suppl):S27-S28. 10.3346/jkms.2000.15.S.S27.
Serotonin and pancreatic duct function
- Affiliations
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- 1Internal Medicine II, Nagoya University School of Medicine, Japan. snaruse@med.nagoya-u.ac.jp
- KMID: 1026940
- DOI: http://doi.org/10.3346/jkms.2000.15.S.S27
Abstract
- 1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
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