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Prognostic value of neutrophil-to-lymphocyte ratio in early-stage ovarian clear-cell carcinoma

Yoshida K, Yoshikawa , Shirakawa , Niimi K, Suzuki S, Kajiyama H, Kikkawa F

OBJECTIVES: There is increasing evidence that systemic inflammatory response (SIR) markers are prognostic factors for various types of cancers. This is the first study to evaluate the usefulness of SIR...
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Serotonin and pancreatic duct function

Naruse S, Suzuki A, Ishiguro H, Kitagawa M, Ko SB, Yoshikawa , Yamamoto A, Hamada H, Hayakawa T

1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT...
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A Case of Muir-Torre Syndrome with Multiple Cancers of Bilateral Eyelids and Breast

Kamisasanuki T, Uchino E, Fukushima , Yoshikawa , Ishibashi , Sakamoto T

We report a case of Muir-Torre syndrome (MTS) with a very rare combination of cancers, involving bilateral eyelid cancers and breast cancer. A 71-year-old female with a history of breast...
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A Rare Case of Lymph Node Metastasis from Early Gastric Cancer

Yoshikawa , Kadokawa Y, Ohana M, Fukuda A, Seno H

Gastric cancers that fulfill the Japanese criteria for curative endoscopic resection show a low risk of lymph node (LN) metastasis. Here, we report a case of LN metastasis from early...
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The Medial Eminence Line for Predicting Tibial Fracture Risk after Unicompartmental Knee Arthroplasty

Yoshikawa , Hiranaka T, Okamoto K, Fujishiro , Hida Y, Kamenaga T, Sakai Y

Background: Tibial fracture after cementless Oxford unicompartmental knee arthroplasty (OUKA) is a rare but serious complication. It is reported more frequently in Asian countries. The aim of this retrospective study...
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Non-Randomized Confirmatory Trial of Laparoscopy-Assisted Total Gastrectomy and Proximal Gastrectomy with Nodal Dissection for Clinical Stage I Gastric Cancer: Japan Clinical Oncology Group Study JCOG1401

Kataoka K, Katai H, Mizusawa J, Katayama H, Nakamura K, Morita S, Yoshikawa , Ito S, Kinoshita , Fukagawa T, Sasako M, Stomach Cancer Study Group/Japan Clinical Oncology Group

Several prospective studies on laparoscopy-assisted distal gastrectomy for early gastric cancer have been initiated, but no prospective study evaluating laparoscopy-assisted total gastrectomy or laparoscopy-assisted proximal gastrectomy has been completed to...
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Seromucinous component in endometrioid endometrial carcinoma as a histological predictor of prognosis

Miyamoto M, Takano M, Aoyama T, Soyama H, Yoshikawa , Tsuda H, Furuya K

OBJECTIVE: In 2014 World Health Organization criteria, seromucinous carcinoma was defined as a new histological subtype in ovarian carcinomas, but “seromucinous carcinoma” was not defined in endometrial carcinomas. The aim...
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Clinicopathologic features of epithelial ovarian carcinoma in younger vs. older patients: analysis in Japanese women

Yoshikawa , Kajiyama H, Mizuno M, Shibata K, Kawai M, Nagasaka T, Kikkawa F

OBJECTIVE: The purpose of this study was to clarify the clinical features of epithelial ovarian carcinoma (EOC) in younger vs. older patients in Japan. METHODS: We collected data on 1,562 patients...
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Comparison of the Japanese Orthopaedic Association Score and the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire Scores: Time-Dependent Changes in Patients with Cervical Spondylotic Myelopathy and Posterior Longitudinal Ligament

Oshima K, Iwasaki M, Sakaura H, Fujimori T, Nagamoto Y, Yoshikawa

STUDY DESIGN: Prospective cohort study. PURPOSE: To identify differences in time-dependent perioperative changes between the Japanese Orthopaedic Association (JOA) score and the JOA Cervical Myelopathy Evaluation Questionnaire (JOACMEQ) score in patients...
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Effects of Weekly Teriparatide Administration for Vertebral Stability and Bony Union in Patients with Acute Osteoporotic Vertebral Fractures

Kitaguchi , Kashii M, Ebina K, Sasaki S, Tsukamoto , Yoshikawa , Murase T

STUDY DESIGN: An open-label, non-randomized prospective study. PURPOSE: Teriparatide (TPTD) is known to be an antiosteoporotic agent that may accelerate the healing of fractures. This study was designed to investigate the...
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Posttreatment human papillomavirus testing for residual or recurrent high-grade cervical intraepithelial neoplasia: a pooled analysis

Onuki M, Matsumoto , Sakurai M, Ochi H, Minaguchi , Satoh T, Yoshikawa

OBJECTIVE: We conducted a pooled analysis of published studies to compare the performance of human papillomavirus (HPV) testing and cytology in detecting residual or recurrent diseases after treatment for cervical...
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Molecular Characterization of Various Trichomonad Species Isolated from Humans and Related Mammals in Indonesia

Kamaruddin M, Tokoro M, Rahman MM, Arayama S, Hidayati A, Syafruddin D, Asih PB, Yoshikawa , Kawahara E

Trichomonad species inhabit a variety of vertebrate hosts; however, their potential zoonotic transmission has not been clearly addressed, especially with regard to human infection. Twenty-one strains of trichomonads isolated from...
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Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas

Miyamoto M, Takano M, Aoyama T, Soyama H, Yoshikawa , Tsuda H, Furuya K

OBJECTIVE: Ovarian clear cell carcinoma (CCC) is one of histological subtypes showing poor prognosis due to chemoresistance. The association of autophagy-related proteins and clinical implementation in CCC has not been...
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Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Mitsui-Iwama M, Yamamoto-Hanada K, Fukutomi Y, Hirota R, Muto G, Nakamura T, Yoshikawa , Nakamura H, Mikami M, Morioka I, Ohya Y

BACKGROUND: Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood. OBJECTIVES:...
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Diagnosis of Myocardial Viability by Fluorodeoxyglucose Distribution at the Border Zone of a Low Uptake Region

Toyota E, Sone T, Yoshikawa , Mimura H, Hayashida , Wada N, Obase K, Imai K, Saito K, Maehama T, Fukunaga M, Yoshida K

PURPOSE: In cardiac 2-[F-18]fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography (PET) examination, interpretation of myocardial viability in the low uptake region (LUR) has been difficult without additional perfusion imaging. We evaluated distribution patterns...
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Role of vaginal pallor reaction in predicting late vaginal stenosis after high-dose-rate brachytherapy in treatment-naive patients with cervical cancer

Yoshida K, Yamazaki H, Nakamura S, Masui K, Kotsuma T, Akiyama H, Tanaka E, Yoshikawa , Uesugi Y, Shimbo T, Narumi Y, Yoshioka Y

OBJECTIVE: To assess actual rates of late vaginal stenosis and identify predisposing factors for complications among patients with previously untreated cervical cancer following high-dose-rate brachytherapy. METHODS: We performed longitudinal analyses of...
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