J Gynecol Oncol.
2018 Mar;29(2):e20. 10.3802/jgo.2018.29.e20.
Seromucinous component in endometrioid endometrial carcinoma as a histological predictor of prognosis
- Affiliations
-
- 1Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Japan.
- 2Department of Clinical Oncology, National Defense Medical College Hospital, Tokorozawa, Japan. mastkn@ndmc.ac.jp
- 3Department of Basic Pathology, National Defense Medical College Hospital, Tokorozawa, Japan.
- KMID: 2404015
- DOI: http://doi.org/10.3802/jgo.2018.29.e20
Abstract
OBJECTIVE
In 2014 World Health Organization criteria, seromucinous carcinoma was defined as a new histological subtype in ovarian carcinomas, but "seromucinous carcinoma" was not defined in endometrial carcinomas. The aim of this study was to identify seromucinous carcinoma resembling ovarian seromucinous carcinoma in endometrial carcinomas, and to evaluate the clinical significance for prognoses of the patients.
METHODS
Central pathological review was conducted for patients with endometrioid carcinoma of the endometrium treated by primary surgery at our hospital between 1990 and 2013.
RESULTS
Among 340 cases included in the study, no case had all tumor cells resembling ovarian seromucinous carcinoma in all specimens, and 31 cases (9.1%) had seromucinous component in combination with endometrioid carcinomas. Immunohistochemical analysis revealed seromucinous component had positive reactivity for cytokeratin (CK) 7, and negative reactivity for CK20 and caudal type homeobox 2 (CDX2) in all cases. Seromucinous component showed lower immunoreactivity of estrogen receptor and progesterone receptor, compared with endometrioid carcinoma component. Progression-free survival of the cases with seromucinous component was better than those without seromucinous component (p=0.049).
CONCLUSION
Seromucinous component was identified in approximately 10% of endometrioid carcinoma, and could be a histological predictor for prognosis.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Microscopic lesions of fallopian tubes in endometrioid carcinoma of the endometrium: How effective are the macroscopic tubal sampling techniques?
- 3 Cases of Synchronous Primary Carcinomas
- Expression of p53 Protein in Endometrial Carcinoma
- A case of simultaneous presentation of uterine endometrial adenocarcinoma with right ovarian endometrioid carcinoma and left ovarian serous adenocarcinoma
- A case of Adult Granulosa Cell Tumor associated with Endometrial Carcinoma
