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Chronic lymphocytic leukemia and concurrent seminoma in the same testis

Miyai K, Kumazawa F, Sato K, Tsuda H

A 59-year-old man presented with a painless testicular mass and underwent a radical orchiectomy. The resected specimen showed a 5-cm-sized, white-yellow and homogenous solid mass in the testicular parenchyma. Histologically,...
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Activated Protein C Anticoagulant System Dysfunction and Thrombophilia in Asia

Hamasaki N, Kuma H, Tsuda H

Thrombophilia that is common among Caucasians is caused by genetic polymorphisms of coagulation factor V Leiden (R506Q) and prothrombin G20210A. Unlike that in Caucasians, thrombophilia that is common in the...
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Seromucinous component in endometrioid endometrial carcinoma as a histological predictor of prognosis

Miyamoto M, Takano M, Aoyama T, Soyama H, Yoshikawa , Tsuda H, Furuya K

OBJECTIVE: In 2014 World Health Organization criteria, seromucinous carcinoma was defined as a new histological subtype in ovarian carcinomas, but “seromucinous carcinoma” was not defined in endometrial carcinomas. The aim...
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Clinical Presentation of Cervical Myelopathy at C1-2 Level

Murahashi , Takebayashi T, Terashima , Tsuda H, Yoshimoto , Yamashita

STUDY DESIGN: Single-center retrospective study. PURPOSE: To clarify the clinical features of cervical myelopathy at the C1-2 level. OVERVIEW OF LITERATURE: Methods for distinguishing the affected level based on myelomere symptoms or...
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Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells

Nakamura M, Ozaki T, Ishii A, Konishi M, Tsubota Y, Furui T, Tsuda H, Mori I, Ota K, Kakudo K

Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to...
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Clear cell histology as a poor prognostic factor for advanced epithelial ovarian cancer: a single institutional case series through central pathologic review

Miyamoto M, Takano M, Goto T, Kato M, Sasaki N, Tsuda H, Furuya K

OBJECTIVE: Compared with serous adenocarcinoma (SAC), clear cell carcinoma (CCC) often shows chemo-resistance, which would potentially lead to a poor prognosis. On the other hand, there have been arguments over...
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Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas

Miyamoto M, Takano M, Aoyama T, Soyama H, Yoshikawa , Tsuda H, Furuya K

OBJECTIVE: Ovarian clear cell carcinoma (CCC) is one of histological subtypes showing poor prognosis due to chemoresistance. The association of autophagy-related proteins and clinical implementation in CCC has not been...
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DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers

Kato M, Takano M, Miyamoto M, Sasaki N, Goto T, Tsuda H, Furuya K

OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not...
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Current status of hereditary breast and ovarian cancer practice among gynecologic oncologists in Japan: a nationwide survey by the Japan Society of Gynecologic Oncology (JSGO)

Kobayashi Y, Masuda K, Hiraswa A, Takehara K, Tsuda H, Watanabe Y, Oda K, Nagase S, Mandai M, Okamoto A, Yaegashi N, Mikami M, Enomoto T, Aoki D, Katabuchi H, Working Group on Clinical Practice for Cancer Genomic Medicine and HBOC, Japan Society of Gynecologic Oncology

Objective The practices pertaining to hereditary breast and ovarian cancer (HBOC) in Japan have been rapidly changing owing to the clinical development of poly(ADP-ribose) polymerase inhibitors, the increasing availability of companion...
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