A case of Adult Granulosa Cell Tumor associated with Endometrial Carcinoma

Lee, Sang Eun; Kim, Dong Kyu; Ahn, Young Sun

Abstract

Granulosa cell tumors of the ovary are rare neoplasms, which account for 2-3% of all ovarian malignancies. There are two types of granulosa cell tumors, adult type and juvenile type. The patients with adult granulosa cell tumors present symptoms of metrorrhagia and amenorrhea due to high serum estrogen level, and maybe accompanied by endometrial hyperplasia in one third of cases and endometrial cancer in 10% of cases. Endometrial cancers have two different pathogenetic types, estrogen-dependent tumors with a history of exposure to unopposed estrogen, and estrogen-independent tumors. In patients with granulosa cells tumors, estrogen-dependent endometrial cancers can be found and most of these endometrial cancers are well differentiated, endometrioid adenocarcinoma and good prognosis due to early detection Although it is known that granulosa cell tumors with endometrial cancers are found in 10% of cases, Finn et al. found no cases of granulosa cell tumors with endometrial cancers. Heric et al. reported 5 of 54 cases of granulosa cell tumors with endometrial cancers, and recently Monzer et al. reported one such case. As we expeirence a case of adult granulosa cell tumor associated with endometrial cancer, we report our case with a literature review.