Asia Pac Allergy.  2019 Jan;9(1):e5. 10.5415/apallergy.2019.9.e5.

Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Affiliations
  • 1Allergy Center, National Center for Child Health and Development, Tokyo, Japan. yamamoto-k@ncchd.go.jp
  • 2Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
  • 3Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara Hospital, Kanagawa, Japan.
  • 4Graduate School of Health Science, Matsumoto University, Nagano, Japan.
  • 5Department of Hygiene, Kitasato University School of Medicine, Kanagawa, Japan.
  • 6Pharmacokinetics and Bioanalysis Center, Shin Nippon Biomedical Laboratories Ltd., Wakayama, Japan.
  • 7Department of Environmental and Preventive Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
  • 8Division of Biostatistics, Department of Data Management, Center for Clinical Research and Development, National Center for Child Health and Development, Tokyo, Japan.

Abstract

BACKGROUND
Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood.
OBJECTIVES
The present study was aimed to examine such exposure among Japanese individuals with allergic diseases.
METHODS
This cross-sectional study included the International Study of Asthma and Allergies in Childhood questionnaire survey to evaluate allergic outcomes and the collection of urine samples to examine Pb and TCS exposure.
RESULTS
Pb containing daily commodities was used in 84.8% children. Pb use was positively associated with current atopic dermatitis (adjusted odds ratio, 4.61; 95% confidence interval, 1.23-17.3). Urinary Pb concentrations were increased significantly in those with current atopic dermatitis (AD) (median, 4.58 vs. 0; p < 0.0001), and showed an increased tendency in those with current wheeze (median, 3.45 vs. 1.81; p = 0.0535) in participants ≤15 years old. Urinary TCS concentration was under the limit of detection in all children.
CONCLUSION
Urinary levels of Pb were associated with current AD in children. We should pay more attention about Pb and TCS.

Keyword

Allergy; Child; Atopic dermatitis; Paraben; Triclosan; Wheezing

MeSH Terms

Asian Continental Ancestry Group
Asthma
Child
Cross-Sectional Studies*
Dermatitis, Atopic
Humans
Hypersensitivity
Limit of Detection
Odds Ratio
Respiratory Sounds
Triclosan*
Triclosan
Full Text Links
  • APA
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr