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Neurotropin protects rotator cuff tendon cells from lidocaine-induced cell death

Abe R, Ohzono H, Gotoh M, Nakamura Y, Honda H, Nakamura H, Kume S, Okawa T, Shiba N

Background: Local anesthetics often are used in rotator cuff tears as therapeutic tools, although some cases have reported that they have detrimental effects. Neurotropin (NTP) is used widely in Japan...
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Exposure to paraben and triclosan and allergic diseases in Tokyo: A pilot cross-sectional study

Mitsui-Iwama M, Yamamoto-Hanada K, Fukutomi Y, Hirota R, Muto G, Nakamura T, Yoshikawa , Nakamura H, Mikami M, Morioka I, Ohya Y

BACKGROUND: Previous studies have reported that exposure to paraben (Pb) and triclosan (TCS) is associated with allergies. However, Pb and TCS exposure in the Japanese population is not fully understood. OBJECTIVES:...
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Utility of Discography as a Preoperative Diagnostic Tool for Intradural Lumbar Disc Herniation

Matsumoto , Toyoda H, Terai H, Dohzono S, Hori Y, Nakamura H

Preoperative definitive diagnosis of intradural lumbar disc herniation (ILDH) is difficult despite the availability of various neuroradiological investigative tools. We present a case of ILDH diagnosed preoperatively by discography and...
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Phase 2 single-arm study on the efficacy and safety of niraparib in Japanese patients with heavily pretreated, homologous recombination-deficient ovarian cancer

Okamoto A, Kondo E, Nakamura T, Yanagida S, Hamanishi J, Harano K, Hasegawa K, Hirasawa T, Hori K, Komiyama S, Matsuura M, Nakai H, Nakamura H, Sakata J, Tabata T, Takehara K, Takekuma M, Yokoyama Y, Kase Y, Sumino S, Soeda J, Suri A, Aoki D, Sugiyama T

Objective: To evaluate the efficacy and safety of niraparib in Japanese women with heavily pretreated ovarian cancer. Methods: This Phase 2 open-label, single-arm study enrolled Japanese women with homologous recombination deficiency-positive...
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Risk of Revision After Vertebral Augmentation for Osteoporotic Vertebral Fracture: A Narrative Review

Takahashi S, Inose H, Tamai K, Iwamae M, Terai H, Nakamura H

Osteoporotic vertebral fractures (OVFs) can hinder physical motor function, daily activities, and the quality of life in elderly patients when treated conservatively. Vertebral augmentation, which includes vertebroplasty and balloon kyphoplasty,...
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Association between Age and Trunk Muscle Area and Density in Patients with Spinal Metastases

Dohzono S, Sasaoka R, Takamatsu K, Nakamura H

Study Design: A retrospective study. Purpose: This study aimed to evaluate the relationship between age and trunk muscle composition and between trunk muscle composition and overall survival in patients with spinal...
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Posterior decentering of the humeral head in patients with arthroscopic rotator cuff repair

Nakamura H, Gotoh M, Honda H, Mitsui Y, Ohzono H, Shiba N, Kume S, Okawa T

Background: In some patients with rotator cuff tear (RCT), the axial view of magnetic resonance imaging (MRI) shows subtle posterior decentering (PD) of the humeral head from the glenoid fossa....
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Effect of suprascapular nerve injury on muscle and regenerated enthesis in a rat rotator cuff tear model

Eshima K, Ohzono H, Gotoh M, Shimokobe H, Tanaka K, Nakamura H, Kanazawa T, Okawa T, Shiba N

Background: Massive rotator cuff tears (RCTs) are complicated by muscle atrophy, fibrosis, and intramuscular fatty degeneration, which are associated with postoperative tendon-to-bone healing failure and poor clinical outcomes. We evaluated...
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Short-Term Risk Factors for Distal Junctional Kyphosis after Spinal Reconstruction Surgery in Patients with Osteoporotic Vertebrae

Sawada Y, Takahashi S, Terai H, Kato M, Toyoda H, Suzuki A, Tamai K, Yabu A, Iwamae M, Nakamura H

Study Design: Level 3 retrospective cohort case-control study. Purpose: This study aimed to investigate the risk factors for distal junctional kyphosis (DJK) caused by osteoporotic vertebral fractures following spinal reconstruction surgery,...
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Can Conventional Magnetic Resonance Imaging Substitute Three-Dimensional Magnetic Resonance Imaging in the Diagnosis of Lumbar Foraminal Stenosis?

Hasib MM, Yamada K, Hoshino M, Yamada E, Tamai K, Takahashi S, Suzuki A, Toyoda H, Terai H, Nakamura H

Study Design: Retrospective radiological comparative design. Purpose: To investigate whether conventional magnetic resonance imaging (MRI) could substitute three-dimensional (3D)-MRI for the calculation of the foraminal stenotic ratio (FSR) and clarification of...
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Does physiotherapy after rotator cuff repair require supervision by a physical therapist?: a meta-analysis

Karasuyama M, Gotoh M, Oike T, Nishie K, Shibuya M, Nakamura H, Ohzono H, Kawakami J

Background: A supervised physiotherapy program (SPP) is a standard regimen after surgical rotator cuff repair (RCR); however, the effect of a home-based exercise program (HEP), as an alternative, on postoperative...
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Surgical Outcomes of Multilevel Posterior Lumbar Interbody Fusion versus Lateral Lumbar Interbody Fusion for the Correction of Adult Spinal Deformity: A Comparative Clinical Study

Iwamae M, Matsumura A, Namikawa T, Kato M, Hori Y, Yabu A, Sawada Y, Hidaka N, Nakamura H

Study Design: A retrospective case control study. Purpose: The purpose of this study was to compare the surgical outcomes of multilevel lateral lumbar interbody fusion (LIF) and multilevel posterior lumbar interbody...
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Prevalence of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Spinal Disorders

Toyoda H, Terai H, Yamada K, Suzuki A, Dohzono S, Matsumoto , Nakamura H

STUDY DESIGN: Retrospective cohort study. PURPOSE: The purpose of this study was to evaluate the prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in patients with spinal diseases determined by roentgen images...
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Clinical outcome in patients with hand lesions associated with complex regional pain syndrome after arthroscopic rotator cuff repair

Imai T, Gotoh M, Fukuda K, Ogino M, Nakamura H, Ohzono H, Shiba N, Okawa T

Background: Complex regional pain syndrome (CRPS)-related hand lesions are one of the complications following arthroscopic rotator cuff repair (ARCR). This study aimed to investigate the clinical outcomes of patients with...
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Effect of Different Types of Upper Instrumented Vertebrae Instruments on Proximal Junctional Kyphosis Following Adult Spinal Deformity Surgery: Pedicle Screw versus Transverse Process Hook

Matsumura , Namikawa T, Kato M, Oyama S, Hori Y, Yabu A, Hidaka N, Nakamura H

STUDY DESIGN: Retrospective comparative study. PURPOSE: To compare the incidence of proximal junctional kyphosis (PJK) between transverse process hooks (TPHs) and pedicle screws (PSs) at the upper instrumented vertebrae (UIV) following...
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Autogenic Rib Graft for Atlantoaxial and Occipitocervical Fixation in Pediatric Patients

Matsumura , Namikawa T, Kato M, Hori Y, Iwamae M, Hidaka N, Konishi S, Nakamura H

STUDY DESIGN: Retrospective case series. PURPOSE: To evaluate surgical outcomes and effectiveness of an autogenic rib graft for upper cervical fixation in pediatric patients. OVERVIEW OF LITERATURE: Autogenic bone grafts have long...
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Clinical and Radiological Outcomes after Microscopic Bilateral Decompression via a Unilateral Approach for Degenerative Lumbar Disease: Minimum 5-Year Follow-Up

Dohzono S, Toyoda H, Matsumura , Terai H, Suzuki A, Nakamura H

STUDY DESIGN: A retrospective study. PURPOSE: To assess postoperative bone regrowth at surgical sites after lumbar decompression with >5 years of follow-up. Postoperative preservation of facet joints and segmental spinal instability...
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