Biomol Ther.  2014 Jan;22(1):47-54.

Beneficial Antioxidative and Antiperoxidative Effect of Cinnamaldehyde Protect Streptozotocin-Induced Pancreatic beta-Cells Damage in Wistar Rats

• Subash-Babu P
• Alshatwi A
• Ignacimuthu S

Abstract

The present study was aimed to evaluate the antioxidant defense system of cinnamaldehyde in normal, diabetic rats and its possible protection of pancreatic beta-cells against its gradual loss under diabetic conditions. In vitro free radical scavenging effect of cinnamaldehyde was determined using DPPH (1,1-diphenyl-2-dipicrylhydrazyl), superoxide radical, and nitric oxide radical. Streptozotocin (STZ) diabetic rats were orally administered with cinnamaldehyde at concentrations of 5, 10 and 20 mg/kg body weight for 45 days. At the end of the experiment, the levels of plasma lipid peroxides and antioxidants such as vitamin C, vitamin E, ceruloplasmin, catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase were determined. A significant increase in the levels of plasma glucose, vitamin E, ceruloplasmin, and lipid peroxides and significant decrease in the levels of plasma insulin and reduced glutathione were observed in the diabetic rats. Also the activities of pancreatic antioxidant enzymes were altered in the STZ-induced diabetic rats. The altered enzyme activities were reverted to near-normal levels after treatment with cinnamaldehyde and glibenclamide. Histopathological studies also revealed a protective effect of cinnamaldehyde on pancreatic beta-cells. Cinnamaldehyde enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic conditions and thus protects pancreatic beta-cells against their loss and exhibits antidiabetic properties.

Keyword

Cinnamaldehyde; Diabetes; beta-Islets; Streptozotocin; Cinnamonum zeylanicum

MeSH Terms

Animals
Antioxidants
Ascorbic Acid
Blood Glucose
Body Weight
Catalase
Ceruloplasmin
Glutathione
Glutathione Peroxidase
Glyburide
Insulin
Lipid Peroxides
Nitric Oxide
Plasma
Rats
Rats, Wistar*
Reactive Oxygen Species
Streptozocin
Superoxide Dismutase
Superoxides
Vitamin E
Vitamins
Antioxidants
Ascorbic Acid
Catalase
Ceruloplasmin
Glutathione
Glutathione Peroxidase
Glyburide
Insulin
Lipid Peroxides
Nitric Oxide
Reactive Oxygen Species
Streptozocin
Superoxide Dismutase
Superoxides
Vitamin E
Vitamins