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Large Hepatocellular Adenoma Presenting with Iron Deficiency Anemia: A Case Report

Koh YK, Yoon SH, Kang SH, Kim H, Im HJ, Ha S, Namgoong JM, Koh KN

Hepatocellular adenoma is an uncommon, benign liver tumor usually occurring in patients using estrogen or anabolic androgens and in those with a genetic disease, including glycogen storage disease. Hepatocellular adenomas...
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Practical strategies for the prevention and management of chronic postsurgical pain

Kim BR, Yoon SH, Lee HJ

Chronic postsurgical pain (CPSP) is a multifactorial condition that affects a significant proportion of patients undergoing surgery. The prevention and management of CPSP require the identification of preoperative risk factors...
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Deep Learning-Based Computed Tomography Image Standardization to Improve Generalizability of Deep Learning-Based Hepatic Segmentation

Lee SB, Hong Y, Cho YJ, Jeong D, Lee J, Yoon SH, Lee S, Choi YH, Cheon JE

Objective: We aimed to investigate whether image standardization using deep learning-based computed tomography (CT) image conversion would improve the performance of deep learning-based automated hepatic segmentation across various reconstruction methods. Materials...
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Optimal Use and Need for Therapeutic Drug Monitoring of Teicoplanin in Children: A Systematic Review

Choi Js, Yoon SH, Park HJ, Lee SY, Kim YJ

Background: Teicoplanin is a glycopeptide antimicrobial that treats serious invasive infections caused by gram-positive bacteria, such as the methicillin-resistant Staphylococcus aureus. Despite some comparable advantages, there is no guideline or...
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Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells that Are Defective in Self-Renewal

Seo BJ, Hong TK, Yoon SH, Song JH, Uhm SJ, Song H, Hong K, Schöler HR, Do JT

Background and Objectives: DNA methyltransferases (Dnmts) play an important role in regulating DNA methylation during early developmental processes and cellular differentiation. In this study, we aimed to investigate the role...
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Effects of rosiglitazone, an antidiabetic drug, on Kv3.1 channels

Lee HM, Yoon SH, Kim MG, Hahn SJ, Choi BH

Rosiglitazone is a thiazolidinedione-class antidiabetic drug that reduces blood glucose and glycated hemoglobin levels. We here investigated the interaction of rosiglitazone with Kv3.1 expressed in Chinese hamster ovary cells using...
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Combined impact of tacrolimus interpatient variability and intrapatient variability on allograft outcomes in kidney transplantation

Park Y, Lee H, Eum SH, Yoon SH, Hwang WM, Yun SR, Yang CW, Shin J, Chung BH

Background: Concentration to dose ratio (CDR) of tacrolimus (TAC) is an index of inter-patient variability that reflects TAC me-tabolism, and whether it influences allograft outcomes is controversial in kidney transplantation...
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Group 1 metabotropic glutamate receptor 5 is involved in synaptically-induced Ca2+ -spikes and cell death in cultured rat hippocampal neurons

Yang JS, Jeon S, Jang HJ, Yoon SH

Group 1 metabotropic glutamate receptors (mGluRs) can positively affect postsynaptic neuronal excitability and epileptogenesis. The objective of the present study was to determine whether group 1 mGluRs might be involved...
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Improvement of Neurodegenerative Disease after Use of Vemurafenib in Refractory BRAF V600E-Mutated Langerhans Cell Histiocytosis: A Case Report

Koh YK, Yoon SH, Kang SH, Kim H, Im HJ, Kim PH, Jung AY, Koh KN

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder characterized by heterogenous lesions infiltrated with CD1a+/CD207+ cells. Although LCH has a relatively good prognosis, the prognosis for patients with LCH...
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Leptomeningeal Spread at the Diagnosis of Glioblastoma Multiforme: A Case Report and Literature Review

Jang C, Cho BK, Hwang SH, Shin HJ, Yoon SH

Approximately two-thirds of glioblastoma (GBM) patients progress to leptomeningeal spread (LMS) within two years. While 90% of LMS cases are diagnosed during the progression and/or recurrence of GBM (defined as...
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Impact of Mediastinal Lymphadenopathy on the Severity of COVID-19 Pneumonia: A Nationwide Multicenter Cohort Study

Lee JE, Jeong WG, Nam BD, Yoon SH, Jeong YJ, Kim YH, Kim SJ, Yoo JY

Background: We analyzed the differences between clinical characteristics and computed tomography (CT) findings in patients with coronavirus disease 2019 (COVID-19) to establish potential relationships with mediastinal lymphadenopathy and clinical outcomes. Methods:...
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A Simple Method for Generating Cerebral Organoids from Human Pluripotent Stem Cells

Hong YJ, Lee Sb, Choi J, Yoon SH, Do JT

Background and Objectives: In recent years, brain organoid technologies have been the most innovative advance in neural differentiation research. In line with this, we optimized a method to establish cerebral organoids...
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Delayed Influenza Treatment in Children With False-Negative Rapid Antigen Test: A Retrospective Single-Center Study in Korea 2016–2019

Lee JY, Baek SH, Ahn JG, Yoon SH, Kim MK, Kim SY, Kim KW, Sohn MH, Kang JM

Background: We aimed to examine the delay in antiviral initiation in rapid antigen test (RAT) false-negative children with influenza virus infection and to explore the clinical outcomes. We additionally conducted...
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Tissue Adequacy and Safety of Percutaneous Transthoracic Needle Biopsy for Molecular Analysis in Non-Small Cell Lung Cancer: A Systematic Review and Meta-analysis

Nam BD, Yoon SH, Hong H, Hwang JH, Goo JM, Park S

Objective: We conducted a systematic review and meta-analysis of the tissue adequacy and complication rates of percutaneous transthoracic needle biopsy (PTNB) for molecular analysis in patients with non-small cell lung...
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CT Examinations for COVID-19: A Systematic Review of Protocols, Radiation Dose, and Numbers Needed to Diagnose and Predict

Lee JH, Hong H, Kim H, Lee CH, Goo JM, Yoon SH

Purpose Although chest CT has been discussed as a first-line test for coronavirus disease 2019 (COVID-19), little research has explored the implications of CT exposure in the population. To review...
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Use of Artificial Intelligence-Based Software as Medical Devices for Chest Radiography: A Position Paper from the Korean Society of Thoracic Radiology

Eui Jin EJ, Goo JM, Yoon SH, Beck KS, Seo JB, Choi BW, Chung MJ, Park CM, Jin KN, Lee SM

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Recurrent Cervical Spontaneous Spinal Epidural Hematoma with Conservative Management: A Case Report

Koo JM, Hwang SH, Yoon J, Yoon SH, Cho BK

Cervical spontaneous spinal epidural hematoma (CSSEH) is a rare condition that can be potentially fatal if not properly diagnosed and managed. While prompt surgical decompression and evacuation of the hematoma...
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Renal Safety of Repeated Intravascular Administrations of Iodinated or Gadolinium-Based Contrast Media within a Short Interval

Kwon C, Kang KM, Choi YH, Yoo RE, Sohn CH, Han SS, Yoon SH

Objective: We aimed to investigate whether repeated intravascular administration of iodinated contrast media (ICM) or gadolinium-based contrast agents (GBCAs) within a short interval was associated with an increased risk of...
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A Prospective, Multi-Center, Double-Blind, Randomized Study to Evaluate the Efficacy and Safety of the Synthetic Bone Graft Material DBM Gel with rhBMP-2 versus DBM Gel Used during the TLIF Procedure in Patients with Lumbar Disc Disease

Hyun SJ, Yoon SH, Kim JH, Oh JK, Lee CH, Shin JJ, Kang J, Ha Y

Objective : This study is to evaluate the efficacy and safety of demineralized bone matrix (DBM) gel versus DBM gel with recombinant human bone morphogenetic protein-2 (rhBMP-2) used in transforaminal...
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Cone-Beam CT-Guided Percutaneous Transthoracic Needle Lung Biopsy of Juxtaphrenic Lesions: Diagnostic Accuracy and Complications

Hong W, Yoon SH, Goo JM, Park CM

Objective: To investigate the diagnostic accuracy and complications of cone-beam CT-guided percutaneous transthoracic needle biopsy (PTNB) of juxtaphrenic lesions and identify the risk factors for diagnostic failure and complications. Materials and...
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