- The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
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Park MH, Choi KY, Min DS
- KMID: 2359887
- Exp Mol Med.
- 2015 Dec;47(12):e200.
- doi: 10.1038/emm.2015.101
Endocytosis is differentially regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) and phospholipase D (PLD). However, the relationship between HIF-1alpha and PLD in endocytosis is unknown. HIF-1alpha is degraded through the prolyl hydroxylase... -
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- Phospholipase D2 promotes degradation of hypoxia-inducible factor-1alpha independent of lipase activity
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Park MH, Bae SS, Choi KY, Min DS
- KMID: 2359883
- Exp Mol Med.
- 2015 Nov;47(11):e196.
- doi: 10.1038/emm.2015.87
Hypoxia-inducible factor-1alpha (HIF-1alpha) is a key transcriptional mediator that coordinates the expression of various genes involved in tumorigenesis in response to changes in oxygen tension. The stability of HIF-1alpha protein... -
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- Euodia sutchuenensis Dode extract stimulates osteoblast differentiation via Wnt/beta-catenin pathway activation
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Hwang JH, Cha PH, Han G, Bach TT, Min DS, Choi KY
- KMID: 2155417
- Exp Mol Med.
- 2015 Mar;47(3):e152.
- doi: 10.1038/emm.2014.115
The Wnt/beta-catenin pathway has a role in osteoblast differentiation and bone formation. We screened 100 plant extracts and identified an extract from Euodia sutchuenensis Dode (ESD) leaf and young branch... -
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- Phospholipase D activates HIF-1-VEGF pathway via phosphatidic acid
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Han S, Huh J, Kim W, Jeong S, Min DS, Jung Y
- KMID: 2155391
- Exp Mol Med.
- 2014 Dec;46(12):e126.
- doi: 10.1038/emm.2014.86
Growth factor-stimulated phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC), generating phosphatidic acid (PA) which may act as a second messenger during cell proliferation and survival. Therefore, PLD is... -
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- Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells
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Hwang WC, Kim MK, Song JH, Choi KY, Min DS
- KMID: 2155389
- Exp Mol Med.
- 2014 Dec;46(12):e124.
- doi: 10.1038/emm.2014.74
Autophagy is a conserved lysosomal self-digestion process used for the breakdown of long-lived proteins and damaged organelles, and it is associated with a number of pathological processes, including cancer. Phospholipase... -
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- Effect of Transurethral Resection of the Prostate Based on the Degree of Obstruction Seen in Urodynamic Study
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Min DS, Cho HJ, Kang JY, Yoo TK, Cho JM
- KMID: 2315940
- Korean J Urol.
- 2013 Dec;54(12):840-845.
PURPOSE: We retrospectively investigated the effect of transurethral resection of the prostate (TURP) on the basis of the degree of obstruction seen in preoperative urodynamic study in patients with benign... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Efficacy of Alfuzosin After Shock Wave Lithotripsy for the Treatment of Ureteral Calculi
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Cho HJ, Shin SC, Seo DY, Min DS, Cho JM, Kang JY, Yoo TK
- KMID: 2316073
- Korean J Urol.
- 2013 Feb;54(2):106-110.
PURPOSE: We evaluated the efficacy of alfuzosin for the treatment of ureteral calculi less than 10 mm in diameter after extracorporeal shock wave lithotripsy (ESWL). MATERIALS AND METHODS: A randomized, single-blind... -
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- The hydrophobic amino acids involved in the interdomain association of phospholipase D1 regulate the shuttling of phospholipase D1 from vesicular organelles into the nucleus
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Jang YH, Min DS
- KMID: 1506220
- Exp Mol Med.
- 2012 Oct;44(10):571-577.
Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine to generate the lipid second messenger, phosphatidic acid. PLD is localized in most cellular organelles, where it is likely to play different... -
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- Rebamipide-induced downregulation of phospholipase D inhibits inflammation and proliferation in gastric cancer cells
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Kang DW, Min G, Park DY, Hong KW, Min DS
- KMID: 1104382
- Exp Mol Med.
- 2010 Aug;42(8):555-564.
- doi: 10.3858/emm.2010.42.8.056
Rebamipide a gastroprotective drug, is clinically used for the treatment of gastric ulcers and gastritis, but its actions on gastric cancer are not clearly understood. Phospholipase D (PLD) is overexpressed... -
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- Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells
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Kang DW, Lee JY, Oh DH, Park SY, Woo TM, Kim MK, Park MH, Jang YH, Min DS
- KMID: 756211
- Exp Mol Med.
- 2009 Sep;41(9):678-685.
- doi: 10.3858/emm.2009.41.9.074
In spite of the importance of phospholipase D (PLD) in cell proliferation and tumorigenesis, little is known about the molecules regulating PLD expression. Thus, identification of small molecules inhibiting PLD... -
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- The expression and cellular localization of phospholipase D isozymes in the developing mouse testis
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Kim S, Kim H, Lee Y, Hyun JW, Lee YH, Shin MK, Min DS, Shin T
- KMID: 1090792
- J Vet Sci.
- 2007 Sep;8(3):209-212.
- doi: 10.4142/jvs.2007.8.3.209
To examine the involvement of phospholipase D (PLD)isozymes in postnatal testis development, the expression ofPLD1 and PLD2 was examined in the mouse testis atpostnatal weeks 1, 2, 4, and 8... -
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- Phospholipase D is activated and phosphorylated by casein kinase-II in human U87 astroglioma cells
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Ahn BH, Min G, Bae YS, Bae YS, Min DS
- KMID: 1105277
- Exp Mol Med.
- 2006 Feb;38(1):55-62.
Elevated expression of protein casein kinase II (CKII) stimulated basal phospholipase D (PLD) activity as well as PMA-induced PLD activation in human U87 astroglioma cells. Moreover, CKII-selective inhibitor, emodin and... -
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- Phospholipase D activity is elevated in hepatitis C virus core protein-transformed NIH3T3 mouse fibroblast cells
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Kim J, Choi BH, Jang KL, Min DS
- KMID: 1123766
- Exp Mol Med.
- 2004 Oct;36(5):454-460.
Hepatitis C Virus (HCV) is associated with a severe liver disease and increased frequency in the development of hepatocellular carcinoma. Overexpression of HCV core protein is known to transform fibroblast... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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- Phospholipase D is involved in oxidative stress-induced migration of vascular smooth muscle cells via tyrosine phosphorylation and protein kinase C
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Kim J, Min G, Bae YS, Min DS
- KMID: 1380203
- Exp Mol Med.
- 2004 Apr;36(2):103-109.
Oxidative stress has been implicated in mediation of vascular disorders. In the presence of vanadate, H2O2 induced tyrosine phosphorylation of PLD1, protein kinase C-a (PKC-a), and other unidentified proteins in... -
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- Efffects of Fluoxetine on ATP-induced Calcium Signaling in PC12 Cells
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Lee YM, Kim HJ, Hong SH, Kim MJ, Min DS, Rhie DJ, Kim MS, Jo YH, Hahn SJ, Yoon SH
- KMID: 1517038
- Korean J Physiol Pharmacol.
- 2004 Feb;8(1):57-63.
Fluoxetine, a widely used anti-depressant compound, has several additional effects, including blockade of voltage-gated ion channels. We examined whether fluoxetine affects ATP-induced calcium signaling in PC12 cells by using fura-2-based... -
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- The Inhibitory Effect of Epicatechin on IL-1beta -induced iNOS Expression and NO Production in RINm5F Cell
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Ryu GR, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Jo YH, Kim MJ
- KMID: 2008132
- J Korean Diabetes Assoc.
- 2003 Dec;27(6):456-466.
BACKGROUND: Interleukin-1beta (IL-1beta ) stimulates the expression of inducible nitric oxide synthase (iNOS) and the production of nitric oxide (NO), lead to NO-mediated insulin, which produces cell damage. Within... -
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- Electrophysiological and Morphological Classification of Inhibitory Interneurons in Layer II/III of the Rat Visual Cortex
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Rhie DJ, Kang HY, Ryu GR, Kim MJ, Yoon SH, Hahn SJ, Min DS, Jo YH, Kim MS
- KMID: 1607516
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):317-323.
Interneuron diversity is one of the key factors to hinder understanding the mechanism of cortical neural network functions even with their important roles. We characterized inhibitory interneurons in layer II/III... -
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- Altered Cholecystokinin-induced Calcium Signal in Streptozotocin-induced Diabetic Rat Pancreatic Acini
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Kim MJ, Ryu GR, Sung JH, Min DS, Rhie DJ, Yoon SH, Hahn SJ, Jo YH, Kim MS
- KMID: 1066043
- Korean J Gastroenterol.
- 2003 Dec;42(6):519-526.
BACKGROUND/AIMS: Pancreatic acini of streptozotocin (STZ)-induced diabetic rats release amylase less than normal acini on cholecystokinin (CCK) stimulation. Pancreatic enzyme secretion has been closely related to the intracellular calcium... -
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