Mycobiology.  2005 Sep;33(3):158-162. 10.4489/MYCO.2005.33.3.158.

Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus

• Kim YR

• KMID: 1596524
• DOI: http://doi.org/10.4489/MYCO.2005.33.3.158

Abstract

The immunomodulatory effect of aqueous extract of Inonotus obliquus, called as Chaga, was tested on bone marrow cells from chemically immunosuppressed mice. The Chaga water extract was daily administered for 24 days to mice that had been treated with cyclophosphamide (400 mg/kg body weight), immunosuppressive alkylating agent. The number of colony-forming unit (CFU)-granulocytes/macrophages (GM) and erythroid burst-forming unit (BFU-E), increased almost to the levels seen in non-treated control as early as 8 days after treatment. Oral administration of the extract highly increased serum levels of IL-6. Also, the level of TNF-alpha was elevated by the chemical treatment in control mice, whereas was maintained at the background level in the extract-treated mice, indicating that the extract might effectively suppress TNF-alpha related pathologic conditions. These results strongly suggest the great potential of the aqueous extract from Inonotus obliquus as immune enhancer during chemotherapy.

Keyword

Bone marrow; Cytokine; Hematopoiesis; Immune modulator; Inonotus obliquus

MeSH Terms

Administration, Oral
Agaricales*
Animals
Bone Marrow
Bone Marrow Cells
Cyclophosphamide
Drug Therapy
Erythroid Precursor Cells
Hematopoiesis
Interleukin-6
Mice
Stem Cells
Tumor Necrosis Factor-alpha
Water*
Cyclophosphamide
Interleukin-6
Tumor Necrosis Factor-alpha
Water