- Voltage-dependent Ca2+ Current Identified in Freshly Isolated Interstitial Cells of Cajal (ICC) of Guinea-pig Stomach
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Kim YC, Suzuki H, Xu WX, Hashitani , Choi W, Yun HY, Park SM, Youn SJ, Lee SJ, Lee SJ
- KMID: 2285359
- Korean J Physiol Pharmacol.
- 2008 Dec;12(6):323-330.
- doi: 10.4196/kjpp.2008.12.6.323
The properties of voltage dependent Ca2+ current (VDCC) were investigated in interstitial cells of Cajal (ICC) distributed in the myenteric layer (ICC-MY) of guinea-pig antrum. In tissue, ICC-MY showed c-Kit... -
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- Effects of arachidonic acid on the calcium channel current (I|B|a) and on the osmotic stretch-induced increase of I|B|a in guinea-pig gastric myocytes
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Xu WX, Kim SJ, So I, Suh SH, Kim KW
- KMID: 2071515
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):435-443.
We employed the whole-cell patch clamp technique to investigate the effects of arachidonic acid (AA) on barium inward current through the L-type calcium channels (IBa) and on osmotic stretch-induced increase of IBa in... -
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- Relaxant Effect of Spermidine on Acethylcholine and High K+-induced Gastric Contractions of Guinea-Pig
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Kim YC, Sim JH, Choi W, Kim CH, You RY, Xu WX, Lee SJ
- KMID: 1486144
- Korean J Physiol Pharmacol.
- 2008 Apr;12(2):59-64.
- doi: 10.4196/kjpp.2008.12.2.59
In our previous study, we found that spermine and putrescine inhibited spontaneous and acetylcholine (ACh)-induced contractions of guinea-pig stomach via inhibition of L-type voltage- dependent calcium current (VDCCL). In this... -
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- Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice
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Song NN, Huang X, Lu HL, Lu C, Chen J, Xu WX
- KMID: 2541577
- J Neurogastroenterol Motil.
- 2023 Apr;29(2):250-261.
- doi: 10.5056/jnm22052
Background/Aims The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients’ life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this... -
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- High K(+)-Induced Relaxation by Nitric Oxide in Human Gastric Fundus
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Kim DH, Kim YC, Choi W, Yun HY, Sung R, Kim HS, Kim H, Yoo RY, Park SM, Yun SJ, Song YJ, Xu WX, Lee SJ
- KMID: 1493961
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):297-303.
- doi: 10.4196/kjpp.2012.16.5.297
This study was designed to elucidate high K(+)-induced relaxation in the human gastric fundus. Circular smooth muscle from the human gastric fundus greater curvature showed stretch-dependent high K+ (50 mM)-induced... -
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- Sodium-activated Potassium Current in Guinea pig Gastric Myocytes
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Kim YC, Sim JH, Kang TM, Suzuki H, Kim SR, Kwon SC, Xu WX, Lee SJ, Kim KW
- KMID: 1713230
- J Korean Med Sci.
- 2007 Feb;22(1):57-62.
- doi: 10.3346/jkms.2007.22.1.57
This study was designed to identify and characterize Na+ -activated K+ current (I(K(Na))) in guinea pig gastric myocytes under whole-cell patch clamp. After whole-cell configuration was established under 110 mM... -
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- Ca2+-activated K+ Current in Freshly Isolated c-Kit Positive Cells in Guinea-pig Stomach
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Kim YC, Suzuki H, Xu WX, Choi W, Kim SH, Lee SJ
- KMID: 1779152
- J Korean Med Sci.
- 2009 Jun;24(3):384-391.
- doi: 10.3346/jkms.2009.24.3.384
This study was designed to isolate Ca2+-activated K+ current (IKCa) and elucidate its physiological significance in freshly isolated interstitial cells of Cajal (ICCs) of guinea-pig stomach. Single ICC was freshly... -
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- Effects of Polyamines on Contractility of Guinea-Pig Gastric Smooth Muscle
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Kim YC, Sim JH, Kim YH, Kwon SC, Lee SJ, Kim SR, Kim DW, Park SM, Youn SJ, Lee SJ, Xing DG, Xu WX, Kim KW
- KMID: 1713229
- J Korean Med Sci.
- 2007 Feb;22(1):48-56.
- doi: 10.3346/jkms.2007.22.1.48
This study was designed to investigate the effects of polyamines on mechanical contraction and voltage-dependent calcium current (VDCC) of guinea-pig gastric smooth muscle. Mechanical contraction and calcium channel current (I(Ba))... -
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- Regulation of L-type Calcium Channel Current by Somatostatin in Guinea-Pig Gastric Myocytes
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Kim YC, Sim JH, Lee SJ, Kang TM, Kim SJ, Kim SR, Youn SJ, Lee SJ, Xu WX, So I, Kim KW
- KMID: 2285316
- Korean J Physiol Pharmacol.
- 2005 Apr;9(2):103-108.
To study the direct effect of somatostatin (SS) on calcium channel current (IBa) in guinea-pig gastric myocytes, IBa was recorded by using whole-cell patch clamp technique in single smooth muscle... -
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- Relaxation Patterns of Human Gastric Corporal Smooth Muscle by Cyclic Nucleotides Producing Agents
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Kim YC, Choi W, Sung R, Kim H, You RY, Park SM, Youn SJ, Kim MJ, Song YJ, Xu WX, Lee SJ, Yun HY
- KMID: 2285388
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):503-510.
- doi: 10.4196/kjpp.2009.13.6.503
To elucidate the mechanism of cyclic nucleotides, such as adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5' -cyclic monophosphate (cGMP), in the regulation of human gastric motility, we examined the effects... -
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- Regional Distribution of Interstitial Cells of Cajal, (ICC) in Human Stomach
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Yun HY, Sung R, Kim YC, Choi W, Kim HS, Kim H, Lee GJ, You RY, Park SM, Yun SJ, Kim MJ, Kim WS, Song YJ, Xu WX, Lee SJ
- KMID: 2071700
- Korean J Physiol Pharmacol.
- 2010 Oct;14(5):317-324.
- doi: 10.4196/kjpp.2010.14.5.317
We elucidated the distribution of interstitial cells of Cajal (ICC) in human stomach, using cryosection and c-Kit immunohistochemistry to identify c-Kit positive ICC. Before c-Kit staining, we routinely used hematoxylin... -
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- Mechanism of Relaxation Via TASK-2 Channels in Uterine Circular Muscle of Mouse
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Hong SH, Sung R, Kim YC, Suzuki H, Choi W, Park YJ, Ji IW, Kim CH, Myung SC, Lee MY, Kang TM, You RY, Lee KJ, Lim SW, Yun HY, Song YJ, Xu WX, Kim HS, Lee SJ
- KMID: 2285471
- Korean J Physiol Pharmacol.
- 2013 Aug;17(4):359-365.
- doi: 10.4196/kjpp.2013.17.4.359
Plasma pH can be altered during pregnancy and at labor. Membrane excitability of smooth muscle including uterine muscle is suppressed by the activation of K+ channels. Because contractility of uterine... -
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- Nitric Oxide-mediated Relaxation by High K+ in Human Gastric Longitudinal Smooth Muscle
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Kim YC, Choi W, Yun HY, Sung R, Yoo RY, Park SM, Yun SJ, Kim MJ, Song YJ, Xu WX, Lee SJ
- KMID: 2285428
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):405-413.
- doi: 10.4196/kjpp.2011.15.6.405
This study was designed to elucidate high-K+induced response of circular and longitudinal smooth muscle from human gastric corpus using isometric contraction. Contraction from circular and longitudinal muscle stripes of gastric... -
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- H2 Receptor-Mediated Relaxation of Circular Smooth Muscle in Human Gastric Corpus: the Role of Nitric Oxide (NO)
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Lee SE, Kim DH, Kim YC, Han JH, Choi W, Kim CH, Jeong HW, Park SM, Yun SJ, Choi SY, Sung R, Kim YH, Yoo RY, Sun PH, Kim H, Song YJ, Xu WX, Yun HY, Lee SJ
- KMID: 2285542
- Korean J Physiol Pharmacol.
- 2014 Oct;18(5):425-430.
- doi: 10.4196/kjpp.2014.18.5.425
This study was designed to examine the effects of histamine on gastric motility and its specific receptor in the circular smooth muscle of the human gastric corpus. Histamine mainly produced... -
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- Regulation of Ba2+-Induced Contraction of Murine Ureteral Smooth Muscle
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Kim YC, Lee MY, Kim WJ, Myung SC, Choi W, Kim CH, Xu WX, Kim SR, Lee SJ
- KMID: 2285344
- Korean J Physiol Pharmacol.
- 2007 Oct;11(5):207-213.
This study was designed to characterize ureteral smooth muscle motility and also to study the effect of forskolin (FSK) and isoproterenol (ISO) on smooth muscle contractility in murine ureter. High... -
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- Myometrial relaxation of mice via expression of two pore domain acid sensitive K⺠(TASK-2) channels
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Kyeong KS, Hong SH, Kim YC, Cho W, Myung SC, Lee MY, You RY, Kim CH, Kwon SY, Suzuki H, Park YJ, Jeong EH, Kim HS, Kim H, Lim SW, Xu WX, Lee SJ, Ji IW
- KMID: 2350512
- Korean J Physiol Pharmacol.
- 2016 Sep;20(5):547-556.
- doi: 10.4196/kjpp.2016.20.5.547
Myometrial relaxation of mouse via expression of two-pore domain acid sensitive (TASK) channels was studied. In our previous report, we suggested that two-pore domain acid-sensing K⺠channels (TASK-2) might be... -
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