- Cross-Regulation of Innate and Adaptive Immunity: A New Perspective for the Pathogenesis of Inflammatory Bowel Disease
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Oh DY, Koh SJ
- KMID: 2155636
- Gut Liver.
- 2015 May;9(3):263-264.
- doi: 10.5009/gnl15123
No abstract available. -
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- Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
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Moon YA, Park SW, Kim KS
- KMID: 1093599
- Exp Mol Med.
- 2002 Mar;34(1):60-68.
The cis-acting element in the promoter of the rat ATP-citrate lyase (ACL) and transcription factors which interact with these elements were determined. Six Sp1 binding sites and CAAT box exist... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer
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You L, Guo X, Huang Y
- KMID: 2418846
- Yonsei Med J.
- 2018 Jan;59(1):35-42.
- doi: 10.3349/ymj.2018.59.1.35
PURPOSE: To investigate the association of cancer stem-cell markers [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and Nanog homebox (NANOG)] expression with clinicopathological properties and overall... -
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- Toward understanding the role of the neuron-specific BAF chromatin remodeling complex in memory formation
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Choi KY, Yoo M, Han JH
- KMID: 2070274
- Exp Mol Med.
- 2015 Apr;47(4):e155.
- doi: 10.1038/emm.2014.129
The long-term storage of memory requires the finely tuned coordination of intracellular signaling with the transcriptional, translational and epigenetic regulations of gene expression. Among the epigenetic mechanisms, however, we know... -
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- Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells
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Byun E, Park B, Lim JW, Kim H
- KMID: 2374084
- Yonsei Med J.
- 2016 May;57(3):647-651.
- doi: 10.3349/ymj.2016.57.3.647
PURPOSE: In the gastric mucosa of Helicobacter pylori (H. pylori)-infected patients with gastritis or adenocarcinoma, proliferation of gastric epithelial cells is increased. Hyperproliferation is related to induction of oncogenes, such... -
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- Immunoexpression of HBME-1, High Molecular Weight Cytokeratin, Cytokeratin 19, Thyroid Transcription Factor-1, and E-cadherin in Thyroid Carcinomas
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Choi YL, Kim MK, Suh JW, Han J, Kim JH, Yang JH, Nam SJ
- KMID: 1781771
- J Korean Med Sci.
- 2005 Oct;20(5):853-859.
- doi: 10.3346/jkms.2005.20.5.853
To examine the immunohistochemical alterations associated with the histological dedifferentiation of thyroid carcinomas, we performed staining for HBME-1, high molecular weight cytokeratin (HCK), CK 19, thyroid transcription factor-1 (TTF-1) and... -
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- Decreased Expression of Surfactant Protein Genes Is Associated with an Increased Expression of Forkhead Box M1 Gene in the Fetal Lung Tissues of Premature Rabbits
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Hahn WH, Chang JY, Lee KS, Bae CW
- KMID: 1798139
- Yonsei Med J.
- 2013 Nov;54(6):1422-1429.
- doi: 10.3349/ymj.2013.54.6.1422
PURPOSE: Recently, Forkhead box M1 (FoxM1) was reported to be correlated with lung maturation and expression of surfactant proteins (SPs) in mice models. However, no study has been conducted in... -
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- Ovarian Clear Cell Carcinoma Sub-Typing by ARID1A Expression
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Choi JY, Han HH, Kim YT, Lee JH, Kim BG, Kang S, Cho NH
- KMID: 2374189
- Yonsei Med J.
- 2017 Jan;58(1):59-66.
- doi: 10.3349/ymj.2017.58.1.59
PURPOSE: Loss of AT-rich DNA-interacting domain 1A (ARID1A) has been identified as a driving mutation of ovarian clear cell carcinoma (O-CCC), a triple-negative ovarian cancer that is intermediary between serous... -
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- Hsp70 and HSF-1 expression is altered in the tissues of pigs transported for various periods of times
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Zhang M, Yue Z, Liu Z, Islam A, Rehana B, Tang S, Bao E, Hartung J
- KMID: 1389764
- J Vet Sci.
- 2012 Sep;13(3):253-259.
- doi: 10.4142/jvs.2012.13.3.253
The aim of this study was to assess changes of Hsp70 and HSF-1 protein and mRNA expression in stress-sensitive organs of pigs during transportation for various periods of time. Twenty... -
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- The Role of Foxo3 in Leydig Cells
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Choi YS, Song JE, Kong BS, Hong JW, Novelli S, Lee EJ
- KMID: 2345887
- Yonsei Med J.
- 2015 Nov;56(6):1590-1596.
- doi: 10.3349/ymj.2015.56.6.1590
PURPOSE: Foxo3 in female reproduction has been reported to regulate proliferation of granulose cells that form follicles. There are no reports so far that discuss on the role of Foxo3... -
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- AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma
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Kwon JH, Ahn KS, Moon YH, Park JY, Wang HJ, Choi KY, Kim G, Joh JW, Lee KG, Kang KJ
- KMID: 2344149
- J Korean Med Sci.
- 2015 Sep;30(9):1253-1259.
- doi: 10.3346/jkms.2015.30.9.1253
Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1... -
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- Expression of TIM-3, Human beta-defensin-2, and FOXP3 and Correlation with Disease Activity in Pediatric Crohn's Disease with Infliximab Therapy
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Kim MJ, Lee WY, Choe YH
- KMID: 2155645
- Gut Liver.
- 2015 May;9(3):370-380.
- doi: 10.5009/gnl13408
BACKGROUND/AIMS: This study investigated the expression of T cell immunoglobulin- and mucin-domain-containing molecule 3 (TIM-3), human beta-defensin (HBD)-2, forkhead box protein 3 (FOXP3), and the frequency of CD4+ CD25+ FOXP3+... -
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- Tempol Attenuates Renal Fibrosis in Mice with Unilateral Ureteral Obstruction: The Role of PI3K-Akt-FoxO3a Signaling
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Yoon HE, Kim SJ, Kim SJ, Chung S, Shin SJ
- KMID: 1789980
- J Korean Med Sci.
- 2014 Feb;29(2):230-237.
- doi: 10.3346/jkms.2014.29.2.230
This study investigated whether tempol, an anti-oxidant, protects against renal injury by modulating phosphatidylinositol 3-kinase (PI3K)-Akt-Forkhead homeobox O (FoxO) signaling. Mice received unilateral ureteral obstruction (UUO) surgery with or without... -
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- The Relationship between HIF-2α and VEGF with Radiographic Severity in the Primary Osteoarthritic Knee
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Jian-lin Z, Hong-song , Hao P, Shuang D, Shen C, Jian-ping , Bo Q, Jin-qing W, Feng L
- KMID: 2374095
- Yonsei Med J.
- 2016 May;57(3):735-740.
- doi: 10.3349/ymj.2016.57.3.735
PURPOSE: The aim of this study was to determine the relationship of hypoxia-inducible factor-2 (HIF-2α) and vascular endothelial growth factor (VEGF) with radiographic severity in primary osteoarthritis (OA) of the... -
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- Weakening of the repressive YY-1 site on the thrombospondin-1 promoter via c-Jun/YY-1 interaction
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Kang JH, Chang SY, Yeom DH, Kim SA, Um SH, Hong KJ
- KMID: 1094074
- Exp Mol Med.
- 2004 Aug;36(4):300-310.
Thrombospondin-1 (TSP-1) level is tightly regulated at the transcriptional level. To determine the detailed molecular mechanisms of TSP-1 expression, nine serial 5'-deletion constructs of the human genomic tsp-1 promoter (nucleotides... -
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- Clinicopathologic significance of the expression of Snail in hepatocellular carcinoma
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Woo HY, Min AL, Choi JY, Bae SH, Yoon SK, Jung CK
- KMID: 1105509
- Korean J Hepatol.
- 2011 Mar;17(1):12-18.
- doi: 10.3350/kjhep.2011.17.1.12
BACKGROUND/AIMS: E-cadherin is involved in intercellular binding and cellular polarity formation. Snail is a key regulator of the epithelial-mesenchymal transition and is closely associated with tumor invasiveness due to its... -
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- Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
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Jang SK, Choi GH, Choi J, Quan X, Jang JW, Kim BH, Jung G, Park YM
- KMID: 1372653
- Korean J Hepatol.
- 2012 Mar;18(1):63-74.
- doi: 10.3350/kjhep.2012.18.1.63
BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for... -
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- CD4+CD25highFoxP3+ Regulatory T-cells in Hematologic Diseases
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Moon HW, Kim BH, Park CM, Hur M, Yun YM, Kim SY, Lee MH
- KMID: 1781685
- Korean J Lab Med.
- 2011 Oct;31(4):231-237.
- doi: 10.3343/kjlm.2011.31.4.231
BACKGROUND: CD4+CD25+ regulatory T-cells (Tregs) play a critical role in immune responses. We explored the status of Tregs in neoplastic and autoimmune hematologic diseases. We also evaluated the technical aspects... -
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