Korean J Hepatol.
2011 Mar;17(1):12-18. 10.3350/kjhep.2011.17.1.12.
Clinicopathologic significance of the expression of Snail in hepatocellular carcinoma
- Affiliations
-
- 1Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea.
- 2Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. jychoi@catholic.ac.kr
- 3Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.
- KMID: 1105509
- DOI: http://doi.org/10.3350/kjhep.2011.17.1.12
Abstract
- BACKGROUND/AIMS
E-cadherin is involved in intercellular binding and cellular polarity formation. Snail is a key regulator of the epithelial-mesenchymal transition and is closely associated with tumor invasiveness due to its ability to suppress E-cadherin expression. We investigated the expressions of E-cadherin and Snail in hepatocellular carcinoma (HCC) tissue to determine the clinical significance of these proteins in HCC.
METHODS
Immunohistochemistry was used to examine the expressions of E-cadherin and Snail in resected tissues from 59 patients diagnosed with HCC. We also evaluated the relationship between the expressions of these two molecules in HCC tissue and clinicopathologic factors in the patients.
RESULTS
Immunohistochemistry showed that Snail was stained in 20.3% of the HCC tissues and 3.4% of noncancerous tissues. Snail was not stained in the area of E-cadherin expression. The expression of Snail in the HCC tissue was associated with poorly differentiated HCC (P=0.028). The expression of Snail without E-cadherin staining in HCC tissue was significantly associated with postoperative HCC recurrence (P=0.013).
CONCLUSIONS
The expression of Snail in HCC tissue was associated with decreased expression of E-cadherin and poorly differentiated HCC. The expression of Snail without E-cadherin staining in HCC was associated with postoperative recurrence.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Correlation between p53 and p27kip1 Expression and Clinicopathologic Features in Hepatocellular Carcinoma
- Immunohistochemical Expression of CD34 and Vascular Endothelial Growth Factor in Hepatocellular Carcinoma
- Prognostic Factors and Clinicopathologic Features after Resection of Small Hepatocellular Carcinoma (< or =2 cm)
- Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
- Clinical significance of GIFTEC test in hepatocellular carcinoma
