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miR-200c-141 Enhances Sheep Kidney Cell Reprogramming into Pluripotent Cells by Targeting ZEB1

Zhang Y, He Y, Wu P, Hu S, Zhang Y, Chen C

Background and Objectives: Sheep-induced pluripotent stem cells (siPSCs) have low reprogramming efficiency, thereby hampering their use in biotechnology and agriculture. Several studies have shown that some microRNAs play an important...
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Role of E-cadherin and cyclin D1 as predictive markers of aggression and clonal expansion in head and neck squamous cell carcinoma

Shergill K, Sen A, Pillai HJ

OBJECTIVES: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Inconsistency in various histopathologic features for predicting nodal metastasis and overall prognosis and a better...
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Luteolin Induces Apoptosis via Mitochondrial Pathway and Inhibits Invasion and Migration of Oral Squamous Cell Carcinoma by Suppressing Epithelial-Mesenchymal Transition Induced Transcription Factors

Park BS, Kil JJ, Kang HM, Yu SB, Park DB, Park JA, Kim IR

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Numerous therapies have been proposed for its cure. Research is continually being conducted to develop new forms...
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Feeder Cells Free Rabbit Oral Mucosa Epithelial Cell Sheet Engineering

Oliva J, Ochiai K, Florentino A, Bardag-Gorce F, Wood A, Niihara Y

The optimal cell culture method of autologous oral mucosal epithelial cell sheet is not well established for a safe transplantation on to the patients' ocular surface. Animal serum and 3T3...
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Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study

Song MJ, Park YS, Song HJ, Park SJ, Ahn JY, Choi KD, Lee GH, Jung HY, Yook JH, Kim BS

BACKGROUND/AIMS: Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer. METHODS: All consecutive patients who presented...
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Hypoxia Increases Epithelial Permeability in Human Nasal Epithelia

Min HJ, Kim TH, Yoon JH, Kim CH

PURPOSE: The nasal mucosa is the first site to encounter pathogens, and it forms continuous barriers to various stimuli. This barrier function is very important in the innate defense mechanism....
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The Epithelial-Mesenchymal Transition and E-cadherin and Vimentin Expression in Basal Cell Carcinoma and Squamous Cell Carcinoma

Kim YU, Kim KJ, Heo EP

  • KMID: 2246223
  • Korean J Dermatol.
  • 2015 Feb;53(2):96-105.
BACKGROUND: The epithelial-mesenchymal transition (EMT) in epithelial tumor cells plays a key role in tumor invasion and metastasis. The reduction or loss of E-cadherin and the acquisition of vimentin are...
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Clinical Significance of Aberrant Wnt7a Promoter Methylation in Human Non-Small Cell Lung Cancer in Koreans

Kim TH, Moon JY, Kim SH, Paik SS, Yoon HJ, Shin DH, Park SS, Sohn JW

The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, and polarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation and cancer, and loss of Wnt7a expression...
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Expression of E-cadherin in pig kidney

Lee SY, Han SM, Kim JE, Chung KY, Han KH

E-cadherin is a cell adhesion molecule that plays an important role in maintaining renal epithelial polarity and integrity. The purpose of this study was to determine the exact cellular localization...
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Bacteroides fragilis Toxin Induces IL-8 Secretion in HT29/C1 Cells through Disruption of E-cadherin Junctions

Hwang S, Gwon SY, Kim MS, Lee S, Rhee KJ

Enterotoxigenic Bacteroides fragilis (ETBF) is a human gut commensal bacteria that causes inflammatory diarrhea and colitis. ETBF also promotes colorectal tumorigenesis in the Min mouse model. The key virulence factor...
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Prostaglandin E2 and Interleukin-1beta Reduce E-cadherin Expression by Enhancing Snail Expression in Gastric Cancer Cells

Jee YS, Jang TJ, Jung KH

Inflammation is closely related to the progression of cancer as well as tumorigenesis. Here, we investigated the effect of prostaglandin E2 (PGE2) and interleukin-1beta (IL-1beta) on E-cadherin expression in SNU719...
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Role of Keratinocytes in the Development of Vitiligo

Lee AY

  • KMID: 2434675
  • Ann Dermatol.
  • 2012 May;24(2):115-125.
Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather...
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Immunohistochemical Study for the Syndecan-1, E-cadher in and Beta-catenin Expressions in Epidermal Tumors

Shin BS, Choi KC, Kim HR, Kim MS

  • KMID: 2247585
  • Korean J Dermatol.
  • 2011 Apr;49(4):309-317.
BACKGROUND: Syndecan-1, E-cadherin and beta-catenin are cell adhesion molecules that are primarily expressed on the surface of adult epithelial cells. The expressions of them appear to be inversely correlated with...
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Clinicopathologic significance of the expression of Snail in hepatocellular carcinoma

Woo HY, Min AL, Choi JY, Bae SH, Yoon SK, Jung CK

BACKGROUND/AIMS: E-cadherin is involved in intercellular binding and cellular polarity formation. Snail is a key regulator of the epithelial-mesenchymal transition and is closely associated with tumor invasiveness due to its...
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Expression of E-cadherin, beta-catenin, Cdx2 and MMP7 in pT2 and N1/N2 Gastric Cancer: Relationship with Tumor Recurrence within 2-Year Period

Kim JH, Eom DY, Kim CW, Choi NK, Kwak JH, Choi GM, Jang HJ, Han MS

PURPOSE: The aim of this study was to examine the expression of E-cadherin, beta-catenin, Cdx2, MMP7 in gastric cancer and to evaluate the clinical significance of these molecules in tumor...
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Epithelial-mesenchymal transition in osteogenic sarcoma of the neck following oral squamous cell carcinoma

Kim HS, Kim NH, Han SH, Cha IH, Seo DJ, Park W, Yook JI, Kim HJ

Postirradiation extraosseous osteogenic sarcomas are uncommon in the head and neck, despite the extensive use of high-dose radiation. It has been described as de novo radiation-induced neoplasm. We present a...
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Cyclooxygenase (COX)-1, Cyclooxygenase (COX)-2 and E-cadherin Expression in Colorectal Cancer Patients with Hepatic Metastasis

Joo SH, Kim BS, Choi SI, Song JY, Lee KY, Kim YW, Kim GY, Lee SH, Lee SM, Hong SW

PURPOSE: Recent studies have shown that cyclooxygenase (COX)-2 may be involved in colorectal carcinogenesis. In this study, we evaluate the differences of COX-2 expression in patients with synchronous and metachronous...
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Expression of E-cadherin, Heat Shock Protein 47, Transforming Growth Factor beta1 and C4d in Chronic Allograft Nephropathy

Chun KW, Park JH, Jung JC, Kim DJ, Park SG, Kim JS, Nam ES, Hyun SJ, Lee S

  • KMID: 2324195
  • J Korean Soc Transplant.
  • 2010 Dec;24(4):298-305.
BACKGROUND: Chronic allograft nephropathy (CAN), which causes graft failure, is related to tubular atrophy and interstitial fibrosis. E-cadherin is a well-known epithelial marker and heat shock protein (HSP)-47 is a...
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E-cadherin Expression in Colonic Epithelium of Various Colitis in Children

Lee NY, Park DY, Park JH

  • KMID: 2275388
  • Korean J Pediatr Gastroenterol Nutr.
  • 2009 Sep;12(2):177-182.
PURPOSE: Colitis is a condition associated with a spectrum of altered morphologic changes and cellular adhesion. E-cadherin plays a key role in the establishment and maintenance of epithelial tissue structure...
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TNF-alpha Downregulates E-cadherin and Sensitizes Response to gamma-irradiation in Caco-2 Cells

Yi JY, Jung YJ, Choi SS, Chung E

  • KMID: 2128578
  • Cancer Res Treat.
  • 2009 Sep;41(3):164-170.
PURPOSE: The purpose of the present study was to assess the biological effects of TNF-alpha in Caco-2 well-differentiated colon adenocarcinoma cells and to determine radiation sensitivity in order to develop...
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