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Identification and comparison of functional microbiomes affecting immune homeostasis in long-term stable and tolerant patients after liver transplantation

Lee SK, Jhun JY, Cho ML, Choi HJ, You YK, Sung PS, Jang JW, Yoon SK, Choi JY

Background: In this study, we aimed to identify the gut microbial balance and functional microbiomes affecting immune homeostasis in the long-term post-liver transplant (LT) and tolerant patients. Methods: A total of...
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Real-life experience of ledipasvir and sofosbuvir for HCV infected Korean patients: a multicenter cohort study

Lee SK, Lee SW, Lee HL, Kim HY, Kim CW, Song DS, Chang UI, Yang JM, Yoo SH, Kwon JH, Nam SW, Kim SH, Song MJ, Lee J, Yang H, Bae SH, Han JW, Nam H, Sung PS, Jang JW, Choi JY, Yoon SK

Background/Aims: To evaluate the efficacy and safety of ledipasvir/sofosbuvir (LDV/SOF) therapy in hepatitis C virus (HCV)-infected Korean patients in a real clinical setting. Methods: A total of 273 patients who received...
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Multidisciplinary approach for hepatocellular carcinoma arising from cirrhotic liver with Budd-Chiari syndrome: a case report

Kim S, Kim JH, Han JW, Jang JW, Choi JY, Yoon SK, Sung PS

Budd-Chiari syndrome (BCS) is defined by the obstruction of the hepatic venous outflow between the small hepatic veins and the junction of the inferior vena cava (IVC) with the right...
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Safety and effectiveness of direct-acting antivirals in patients with chronic hepatitis C and chronic kidney disease

Ryu JE, Song MJ, Kim SH, Kwon JH, Yoo SH, Nam SW, Nam HC, Kim HY, Kim CW, Yang H, Bae SH, Song DS, Chang UI, Yang JM, Lee SW, Lee HL, Lee SK, Sung PS, Jang JW, Choi JY, Yoon SK

Background/Aims: To evaluate the effectiveness and safety of direct acting antivirals (DAAs) available in chronic kidney disease (CKD) patients with hepatitis C virus (HCV) infection in Korea. Methods: In a retrospective,...
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Nuss Procedure for Surgical Stabilization of Anterior Flail Chest with Mechanical Ventilation Weaning Failure: A Case Report

Kim D, Yoon SK, Lee GD, Kim DK

Flail chest is a critical medical condition in which multiple segmentally fractured adjacent ribs cause paradoxical movement of the thoracic cage in patients with severe blunt trauma injury. Surgical stabilization...
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Diagnostic performance of serum exosomal miRNA-720 in hepatocellular carcinoma

Jang JW, Kim JM, Kim HS, Kim JS, Han JW, Lee SK, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK

Background/Aim: Hepatocellular carcinoma (HCC) is associated with poor prognosis, largely due to late detection. Highly accurate biomarkers are urgently needed to detect early-stage HCC. Our study aims to explore the...
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Risk Factors for Renal Function Impairment Following Radiofrequency Ablation of Renal Tumors

Park IC, Yoon SK, Kim DW

Purpose To evaluate the various factors that affect renal function following percutaneous radiofrequency ablation (RFA) therapy in patients with renal tumors. Materials and Methods Between 2010 and 2018, 91 patients diagnosed with renal...
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Anti-fibrotic effects of branched-chain amino acids on hepatic stellate cells

Lee HL, Lee J, Cha JH, Cho S, Sung PS, Hur W, Yoon SK, Bae SH

Background/Aims: Patients with liver cirrhosis (LC) have low levels of branchedchain amino acids (BCAAs). There is accumulating evidence that BCAAs have anti- fibrotic effects in cirrhosis. This study is aimed...
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Multilocular Cystic Renal Neoplasm of Low Malignant Potential: A Case Report and Literature Review

Lee J, Kim DW, Song JY, Yoon SK

Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) is a rare subtype of renal cell carcinoma that has a favorable outcome. Most cases of MCRNLMP usually present as distinct...
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Analysis of Medical Consultation Patterns in Medical and Surgical Intensive Care Units: Changes in the Pattern of Consultation after the Implementation of Intensivist-Directed Care

Bang MJ, Yoon SK, Yoon KW, Gil E, Yoo K, Choi KJ, Park CM

Purpose: Critically ill patients often require multidisciplinary treatment for both acute illnesses and pre-existing medical conditions. Since different medical conditions are managed in the intensive care unit (ICU), consultation is...
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Use of Gemcitabine plus Carboplatin is Associated with Poor Outcomes in Urothelial Carcinoma Patients with Chronic Kidney Disease Stage 4-5

Kim HD, Im HS, Kim JH, Jeong H, Yoon SK, Park I, Lee JL

Purpose This study aimed to investigate the clinical outcomes with gemcitabine-carboplatin (GCb), the standard treatment for patients with advanced urothelial carcinoma (UC) who are ineligible for cisplatin-based regimens, in advanced...
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Urothelial Carcinoma of the Bladder: Radiologic Perspective

Kim DW, Yoon SK, Kim SH

Bladder cancer is a relatively common cancer type, with a high recurrence rate, that can be often encountered in the imaging study. Accurate diagnosis and staging have a significant impact...
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Thoracic Chordoma Misdiagnosed as Primary Adenocarcinoma of the Mediastinum

Yoon SK, Moon MH, Moon SW

Chordoma is a rare malignant bone tumor originating from the embryonic notochord. Herein, we present a case of thoracic chordoma located at T3–T5 that was misdiagnosed as primary mediastinal adenocarcinoma. The...
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Effect of the Proximal Anastomosis Configuration of the Radial Artery in Patients Undergoing Coronary Artery Bypass Grafting

Yoon SK, Song H, Lim JY

Background: Several factors, such as the degree of target vessel stenosis, are known to be associated with radial artery (RA) graft patency in coronary artery bypass grafting (CABG). There is...
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Continuing besifovir dipivoxil maleate versus switching from tenofovir disoproxil fumarate for treatment of chronic hepatitis B: Results of 192-week phase 3 trial

Song DS, Kim W, Ahn SH, Yim HJ, Jang JY, Kweon YO, Cho YK, Kim YJ, Hong GY, Kim DJ, Jung YK, Sohn JH, Lee JW, Park SJ, Lee BS, Kim JH, Kim HS, Yoon SK, Kim MY, Lee KS, Lim YS, Lee WS, Yang JM, Kim KH, Han KH, Um SH

Background/Aims: Besifovir dipivoxil maleate (BSV), an acyclic nucleotide phosphonate, shows potent antiviral activity against hepatitis B virus. Our previous 48-week trial revealed that BSV has comparable antiviral efficacy to tenofovir...
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Targeted Next-Generation Sequencing of Plasma CellFree DNA in Korean Patients with Hepatocellular Carcinoma

Chae H, Sung PS, Choi H, Kwon A, Kang D, Kim Y, Kim M, Yoon SK

Background: Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer-related deaths worldwide, and an accurate and non-invasive biomarker for the early detection and monitoring of HCC is required. We assessed...
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Persistence of intrahepatic hepatitis B virus DNA integration in patients developing hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Jang JW, Kim JS, Kim HS, Tak KY, Nam H, Sung PS, Bae SH, Choi JY, Yoon SK, Roberts LR

Background/Aims: The role of hepatitis B virus (HBV) integration into the host genome in hepatocarcinogenesis following hepatitis B surface antigen (HBsAg) seroclearance remains unknown. Our study aimed to investigate and...
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Obesity and the risk of primary liver cancer: A systematic review and meta-analysis

Sohn W, Lee HW, Lee S, Lim JH, Lee MW, Park CH, Yoon SK

Background/Aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer. Methods: This study was conducted using...
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Factors of Determining N-acetylcysteine Administration in Patients with Acute Acetaminophen Poisoning

Lee JH, Choi S, Yoon SK, Shin KC

Purpose: In acute acetaminophen poisoning, the administration of N-acetylcysteine (NAC) can effectively treat the main complications, such as kidney injury and liver failure. In the current situation, measurements of the...
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Infiltration of T Cells and Programmed Cell Death Ligand 1-expressing Macrophages as a Potential Predictor of Lenvatinib Response in Hepatocellular Carcinoma

Sung PS, Cho SW, Lee J, Yang H, Jang JW, Bae SH, Choi JY, Yoon SK

Background/Aims: Lenvatinib was recently proven to be non-inferior to sorafenib in treating unresectable hepatocellular carcinoma (HCC) in a phase-3 randomized controlled trial. In this study, we investigated whether the response...
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