J Liver Cancer.  2020 Mar;20(1):84-89. 10.17998/jlc.20.1.84.

Successful Sequential Therapy Involving Regorafenib after Failure of Sorafenib in a Patient with Recurrent Hepatocellular Carcinoma after Liver Transplantation

• Lee SK
• Jang JW
• Nam H
• Sung PS
• Bae SH
• Choi JY
• Yoon SK

• KMID: 2505847
• DOI: http://doi.org/10.17998/jlc.20.1.84

Abstract

The efficacy and safety of sequential systemic therapy for the treatment of recurrent hepatocellular carcinoma (HCC) after liver transplantation (LT) are not well established. This study describes a successful experience where sequential therapy with sorafenib followed by regorafenib was used to treat recurrent HCC in a 54-year old male LT recipient. After HCC recurred in both lungs 10 months after LT, sorafenib was administered with radiation therapy to treat pulmonary metastases. However, after 4 months of sorafenib treatment showed progressive pulmonary metastases, sequential regorafenib treatment was started. After 3 months (cycles) of regorafenib treatment, tumor response was partial, and after 6 months (cycles), disease status remained stable without signs of progression or drug-related serious adverse events. This case suggests that sequential systemic therapy is feasible in patient with recurrent HCC after LT.

Keyword

Liver transplantation; Hepatocellular carcinoma; Sorafenib; Regorafenib; Metastasis

Figure

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  Figure 1. Initial chest computed tomography findings. (A) Pulmonary metastases (arrows) before sorafenib treatment. (B) Overall pulmonary metastases (arrows) progression after sorafenib treatment.

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  Figure 2. Follow-up chest computed tomography findings. (A) Overall partial response of pulmonary metastases (arrows) after 3 cycles of regorafenib. (B) Overall stable status of pulmonary metastases (arrows) after 6 cycles of regorafenib.

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