J Korean Cancer Assoc.
2000 Apr;32(2):390-397.
Correlation between p53 and p27kip1 Expression and Clinicopathologic Features in Hepatocellular Carcinoma
Abstract
-
PURPOSE: The aim of this study was to evaluate the expression of p53 and p27Kip1 and its
association with numerous prognostic indicators of hepatocellular carcinoma (HCC).
MATERIALS AND METHODS
We reviewd the clinicopathologic features of 59 patients with HCC between 1993 and 1998. p53 and p27Kip1 expression were evaluated for relation with level of AFP, presence of HBsAg and microscopic findings such as Edmonson grade, grade of mitosis, cirrhotic background, tumor margin and Ki67 labeling index.
RESULTS
The expression rate of p53 was positively correlated with with Edmonson grade, high mitosis, infiltrative tumor margin and level of serum AFP. The expression rate of p27Kip1 was correlated inversely with Edmonson grade and presence of cirrhotic background. Ki67 labeling index was well correlated with Edmonson grade and mitotic activity. There was no correalation between p53 and p27Kip1 expression.
CONCLUSION
The aberrant expression of p53 and p27Kip1 is well associated with various prognostic factors of HCC.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Correlation between p53 and Rb Protein Expression and Clinicopathologic Features in Hepatocellular Carcinoma
- p27Kipl, K-67 and Bcl-2 Expression in Adenoid Cystic Carcinoma of Head and Neck
- P53 expression in hepatocellular carcinoma: influence on the radiotherapeutic response of the hepatocellular carcinoma
- Expression of Proteins Related Cell Cycle and Apoptosis during Diethylnitrosamine (DEN)-induced Hepatocarcinogenesis in Rats
- Analysis of Expression of p63 in Cervical Neoplasia Comparing with Other Immunohistochemical Markers
