- Potential Role of Sirtuin as a Therapeutic Target for Neurodegenerative Diseases
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Han SH
- KMID: 2045417
- J Clin Neurol.
- 2009 Sep;5(3):120-125.
- doi: 10.3988/jcn.2009.5.3.120
The sirtuins (SIRTs) are protein-modifying enzymes that are distributed ubiquitously in all organisms. SIRT1 is a mammalian homologue of yeast nicotinamide-adenine-dinucleotide-dependent deacetylase silent information regulator 2 (known as Sir2), which... -
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- Sirt1 as a New Therapeutic Target in Metabolic and Age-Related Diseases
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Lee DH
- KMID: 1730001
- Chonnam Med J.
- 2010 Aug;46(2):67-73.
- doi: 10.4068/cmj.2010.46.2.67
Sirt1 among the mammalian sirtuins has generated intense scientific interest in recent years, mainly because of its effects on longevity, metabolism, and other aging-related processes. Via nicotinamide adenine dinucleotide (NAD)-dependent... -
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- Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation
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Wang Y
- KMID: 2280675
- Diabetes Metab J.
- 2014 Oct;38(5):321-329.
- doi: 10.4093/dmj.2014.38.5.321
Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with... -
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- Carcinogenic Compounds, 2-nitrofluorene and Clonidine Can Modulate the Level of Sirtuin mRNAs Expression in Human Adipose Tissue-derived Stem Cells
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Lee J, Lee CY, Kwon Y, Kim H, Kim H
- KMID: 1982461
- Korean J Phys Anthropol.
- 2014 Dec;27(4):235-243.
- doi: 10.11637/kjpa.2014.27.4.235
Sirtuins (SIRTs) are involved in multiple cellular processes. And they are involved in cellular pathways related aging, cancer, and a variety of cellular functions including cell cycle, DNA repair and... -
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- Mitochondrial Mechanisms in Diabetic Cardiomyopathy
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Gollmer J, Zirlik A, Bugger H
- KMID: 2470953
- Diabetes Metab J.
- 2020 Feb;44(1):33-53.
- doi: 10.4093/dmj.2019.0185
Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus... -
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- Expression of SIRT1 and SIRT3 varies according to age in mice
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Kwon Y, Kim J, Lee CY, Kim H
- KMID: 2046075
- Anat Cell Biol.
- 2015 Mar;48(1):54-61.
- doi: 10.5115/acb.2015.48.1.54
Sirtuins (SIRTs) are involved in multiple cellular processes including those related to aging, cancer, and a variety of cellular functions including cell cycle progression, DNA repair, and cellular proliferation. SIRTs... -
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- Prognostic Significance of Sirtuins Expression in Papillary Thyroid Carcinoma
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Kang YE, Shong M, Kim JM, Koo BS
- KMID: 2448985
- Int J Thyroidol.
- 2018 Nov;11(2):143-151.
- doi: 10.11106/ijt.2018.11.2.143
BACKGROUND AND OBJECTIVES: Sirtuins (SIRTs) play important roles in cellular and organismal homeostasis. They have distinct gene expression patterns in various cancers; however, the relationship between SIRT expression and the... -
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- Duodenal-Jejunal Bypass Surgery Stimulates the Expressions of Hepatic Sirtuin1 and 3 and Hypothalamic Sirtuin1
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Ha E, Kang JY, Park KS, Seo YK, Ha TK
- KMID: 2436617
- J Obes Metab Syndr.
- 2018 Dec;27(4):248-253.
- doi: 10.7570/jomes.2018.27.4.248
BACKGROUND: Sirtuins mediate metabolic responses to nutrient availability and slow aging and accompanying decline in health. This study was designed to assess the expressions of sirtuin1 (SIRT1) and sirtuin3 (SIRT3)... -
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- Luteolin and fisetin suppress oxidative stress by modulating sirtuins and forkhead box O3a expression under in vitro diabetic conditions
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Kim A, Lee W, Yun JM
- KMID: 2390136
- Nutr Res Pract.
- 2017 Oct;11(5):430-434.
- doi: 10.4162/nrp.2017.11.5.430
BACKGROUND/OBJECTIVE: Chronic hyperglycemia induces oxidative stress via accumulation of reactive oxygen species (ROS) and contributes to diabetic complications. Hyperglycemia induces mitochondrial superoxide anion production through the increased activity of nicotinamide... -
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- Emodin exerts protective effect against palmitic acid-induced endoplasmic reticulum stress in HepG2 cells
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Thomas SS, Park S, Cha YS, Kim KA
- KMID: 2444941
- J Nutr Health.
- 2019 Apr;52(2):176-184.
- doi: 10.4163/jnh.2019.52.2.176
PURPOSE: Protein overloading in the endoplasmic reticulum (ER) leads to endoplasmic reticulum stress, which exacerbates various disease conditions. Emodin, an anthraquinone compound, is known to have several health benefits. The... -
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- Supplementation with psyllium seed husk reduces myocardial damage in a rat model of ischemia/reperfusion
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Lim SH, Lee J
- KMID: 2453284
- Nutr Res Pract.
- 2019 Jun;13(3):205-213.
- doi: 10.4162/nrp.2019.13.3.205
BACKGROUND/OBJECTIVES: Myocardial infarction (MI) is caused by extensive myocardial damage attributed to the occlusion of coronary arteries. Our previous study in a rat model of ischemia/reperfusion (I/R) demonstrated that administration... -
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- AMP-activated protein kinase as a key molecular link between metabolism and clockwork
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Lee Y, Kim EK
- KMID: 2154252
- Exp Mol Med.
- 2013 Jul;45(7):e33.
Circadian clocks regulate behavioral, physiological and biochemical processes in a day/night cycle. Circadian oscillators have an essential role in the coordination of physiological processes with the cyclic changes in the... -
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- Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
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Lee HJ, Yang SJ
- KMID: 2434070
- Nutr Res Pract.
- 2019 Feb;13(1):3-10.
- doi: 10.4162/nrp.2019.13.1.3
BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents... -
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- Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function
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Moon J, Kim HR, Shin MG
- KMID: 2434727
- Ann Lab Med.
- 2018 Sep;38(5):395-401.
- doi: 10.3343/alm.2018.38.5.395
Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very... -
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- SIRT1 promotes DNA repair activity and deacetylation of Ku70
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Jeong J, Juhn K, Lee H, Kim SH, Min BH, Lee KM, Cho MH, Park GH, Lee KH
- KMID: 1103676
- Exp Mol Med.
- 2007 Feb;39(1):8-13.
Human SIRT1 controls various physiological responses including cell fate, stress, and aging, through deacetylation of its specific substrate protein. In processing DNA damage signaling, SIRT1 attenuates a cellular apoptotic response... -
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