Diabetes Metab J.  2020 Feb;44(1):33-53. 10.4093/dmj.2019.0185.

Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Affiliations
  • 1Division of Cardiology, Medical University of Graz, Graz, Austria. heiko.bugger@medunigraz.at

Abstract

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus (DM), defects in mitochondrial structure and function occur in many organs throughout the body, contributing both to the pathogenesis of DM and complications of DM. Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitochondrial mechanisms have been proposed to contribute to the development of DbCM. Well established mechanisms include myocardial energy depletion due to impaired adenosine triphosphate (ATP) synthesis and mitochondrial uncoupling, and increased mitochondrial oxidative stress. A variety of upstream mechanisms of impaired ATP regeneration and increased mitochondrial reactive oxygen species have been proposed, and recent studies now also suggest alterations in mitochondrial dynamics and autophagy, impaired mitochondrial Ca²âº uptake, decreased cardiac adiponectin action, increased O-GlcNAcylation, and impaired activity of sirtuins to contribute to mitochondrial defects in DbCM, among others. In the current review, we present and discuss the evidence that underlies both established and recently proposed mechanisms that are thought to contribute to mitochondrial dysfunction in DbCM.

Keyword

Diabetes mellitus; Diabetic cardiomyopathies; Heart failure; Mitochondria

MeSH Terms

Adenosine Triphosphate
Adiponectin
Autophagy
Diabetes Mellitus
Diabetic Cardiomyopathies*
Heart Failure
Mitochondria
Mitochondrial Dynamics
Oxidative Stress
Reactive Oxygen Species
Regeneration
Sirtuins
Adenosine Triphosphate
Adiponectin
Reactive Oxygen Species
Sirtuins
Full Text Links
  • DMJ
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error