- Mitochondrial Dynamics in the Heart as a Novel Therapeutic Target for Cardioprotection
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Hwang SJ, Kim W
- KMID: 2048813
- Chonnam Med J.
- 2013 Dec;49(3):101-107.
- doi: 10.4068/cmj.2013.49.3.101
Traditionally, mitochondria have been regarded solely as energy generators for cells; however, accumulating data have demonstrated that these complex organelles play a variety of roles within the cardiomyocyte that extend... -
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- Control of Mitochondrial Dynamics by Fas-induced Caspase-8 Activation in Hippocampal Neurons
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Cho HM, Sun W
- KMID: 2165558
- Exp Neurobiol.
- 2015 Sep;24(3):219-225.
- doi: 10.5607/en.2015.24.3.219
Cells undergo apoptosis mainly via two pathways-the mitochondrial pathway and the cytosolic pathway. It has been well documented that activation of the mitochondrial pathway promotes mitochondrial fragmentation and inhibition of... -
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- Mitochondrial Mechanisms in Diabetic Cardiomyopathy
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Gollmer J, Zirlik A, Bugger H
- KMID: 2470953
- Diabetes Metab J.
- 2020 Feb;44(1):33-53.
- doi: 10.4093/dmj.2019.0185
Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus... -
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- Physiological and Pathological Significance of Dynamin-Related Protein 1 (Drp1)-Dependent Mitochondrial Fission in the Nervous System
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Cho B, Choi SY, Cho HM, Kim HJ, Sun W
- KMID: 2165478
- Exp Neurobiol.
- 2013 Sep;22(3):149-157.
- doi: 10.5607/en.2013.22.3.149
Mitochondria are essential for proper neuronal morphogenesis and functions, as they are the major source of energy for neural development. The dynamic morphology of mitochondria determines the key functions of... -
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- miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
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Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK
- KMID: 2155388
- Exp Mol Med.
- 2014 Nov;46(11):e123.
- doi: 10.1038/emm.2014.73
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial... -
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- Effects of Acute Exercise on Mitochondrial Function, Dynamics, and Mitophagy in Rat Cardiac and Skeletal Muscles
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Yoo SZ, No MH, Heo JW, Park DH, Kang JH, Kim JH, Seo DY, Han J, Jung SJ, Kwak HB
- KMID: 2448804
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S22-S31.
- doi: 10.5213/inj.1938038.019
PURPOSE: This study aimed to investigate the effects of single-bout exercise on mitochondrial function, dynamics (fusion, fission), and mitophagy in cardiac and skeletal muscles. METHODS: Fischer 344 rats (4 months old)... -
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- Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes
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Lee H, Song W
- KMID: 2436604
- J Obes Metab Syndr.
- 2018 Sep;27(3):150-157.
- doi: 10.7570/jomes.2018.27.3.150
Exercise is regarded as a potent stimulus in modulation of glucose utility and mitochondrial adaptations in skeletal muscle, leading to enhanced metabolic health. As mitochondria play a crucial role in... -
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- Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
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Heo JW, No MH, Park DH, Kang JH, Seo DY, Han J, Neufer PD, Kwak HB
- KMID: 2395251
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):567-577.
- doi: 10.4196/kjpp.2017.21.6.567
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all associated with mitochondrial dysfunction in skeletal muscle.... -
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- Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells
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Park KS, Wiederkehr A, Wollheim C
- KMID: 2285443
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):71-77.
- doi: 10.4196/kjpp.2012.16.1.71
Mitochondrial dynamics and distribution is critical for their role in bioenergetics and cell survival. We investigated the consequence of altered fission/fusion on mitochondrial function and motility in INS-1E rat clonal... -
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- High Glucose Causes Human Cardiac Progenitor Cell Dysfunction by Promoting Mitochondrial Fission: Role of a GLUT1 Blocker
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Choi HY, Park JH, Jang WB, Ji ST, Jung SY, Kim DY, Kang S, Kim YJ, Yun J, Kim JH, Baek SH, Kwon SM
- KMID: 2351684
- Biomol Ther.
- 2016 Jul;24(4):363-370.
- doi: 10.4062/biomolther.2016.097
Cardiovascular disease is the most common cause of death in diabetic patients. Hyperglycemia is the primary characteristic of diabetes and is associated with many complications. The role of hyperglycemia in... -
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- Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease
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Tang J, Oliveros A, Jang MH
- KMID: 2448802
- Int Neurourol J.
- 2019 Feb;23(Suppl 1):S5-S10.
- doi: 10.5213/inj.1938036.018
Synapses are sites of high energy demand which are dependent on high levels of mitochondrial derived adenosine triphosphate. Mitochondria within synaptic structures are key for maintenance of functional neurotransmission and... -
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- Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation
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Kim DY, Jung SY, Kim YJ, Kang S, Park JH, Ji ST, Jang WB, Lamichane , Lamichane , Chae YC, Lee D, Chung JS, Kwon SM
- KMID: 2410110
- Korean J Physiol Pharmacol.
- 2018 Mar;22(2):203-213.
- doi: 10.4196/kjpp.2018.22.2.203
Tumor undergo uncontrolled, excessive proliferation leads to hypoxic microenvironment. To fulfill their demand for nutrient, and oxygen, tumor angiogenesis is required. Endothelial progenitor cells (EPCs) have been known to the... -
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- Etoposide Induces Mitochondrial Dysfunction and Cellular Senescence in Primary Cultured Rat Astrocytes
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Bang M, Kim DG, Gonzales E, Kwon KJ, Shin CY
- KMID: 2462880
- Biomol Ther.
- 2019 Nov;27(6):530-539.
- doi: 10.4062/biomolther.2019.151
Brain aging is an inevitable process characterized by structural and functional changes and is a major risk factor for neurodegenerative diseases. Most brain aging studies are focused on neurons and... -
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- A novel p.Leu699Pro mutation in MFN2 gene causes Charcot-Marie-Tooth disease type 2A
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Kang SY, Ko KH, Oh JH
- KMID: 2434189
- Ann Clin Neurophysiol.
- 2019 Jan;21(1):57-60.
- doi: 10.14253/acn.2019.21.1.57
Axonal Charcot-Marie-Tooth disease (CMT2) has most frequently been associated with mutations in the MFN2 gene. MFN2 encodes mitofusin 2, which is a mitochondrial fusion protein that plays an essential role... -
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- Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes β-Cell Impairment via Mitochondrial Dysregulation
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Hong SW, Lee J, Kwon H, Park SE, Rhee EJ, Park CY, Oh KW, Park SW, Lee WY
- KMID: 2447031
- Endocrinol Metab.
- 2018 Sep;33(3):403-412.
- doi: 10.3803/EnM.2018.33.3.403
BACKGROUND: Emerging evidence suggests that sphingolipids may be involved in type 2 diabetes. However, the exact signaling defect through which disordered sphingolipid metabolism induces β-cell dysfunction remains unknown. The current... -
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- LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
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Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W
- KMID: 2416244
- Exp Neurobiol.
- 2018 Jun;27(3):171-180.
- doi: 10.5607/en.2018.27.3.171
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,... -
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- Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury
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Park DJ, Kim MO, Koh PO
- KMID: 2391092
- Lab Anim Res.
- 2017 Sep;33(3):202-208.
- doi: 10.5625/lar.2017.33.3.202
Ischemic stroke is one of the leading causes of adult disability and death. Hyperglycemia is associated with an increased risk of stroke and poor outcomes after brain injury. Dynamin-like protein... -
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- The First Generation of iPSC Line from a Korean Alzheimer's Disease Patient Carrying APP-V715M Mutation Exhibits a Distinct Mitochondrial Dysfunction
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Li L, Roh JH, Kim HJ, Park HJ, Kim M, Koh W, Heo H, Chang JW, Nakanishi , Yoon T, Na DL, Song J
- KMID: 2451069
- Exp Neurobiol.
- 2019 Jun;28(3):329-336.
- doi: 10.5607/en.2019.28.3.329
Alzheimer's Disease (AD) is a progressive neurodegenerative disease, which is pathologically defined by the accumulation of amyloid plaques and hyper-phosphorylated tau aggregates in the brain. Mitochondrial dysfunction is also a... -
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- Progression of Multifaceted Immune Cells in Atherosclerotic Development
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Park S, Lee IK
- KMID: 2447753
- J Lipid Atheroscler.
- 2019 May;8(1):15-25.
- doi: 10.12997/jla.2019.8.1.15
Atherosclerosis is a major cause of morbidity and mortality due to cardiovascular diseases, such as coronary artery disease, stroke, and peripheral vascular disease, that are associated with thrombosis-induced organ infarction.... -
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- Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling
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Park J, Seo J, Won J, Yeo HG, Ahn YJ, Kim K, Jin YB, Koo BS, Lim KS, Jeong KJ, Kang P, Lee HY, Baek SH, Jeon CY, Hong JJ, Huh JW, Kim YH, Park SJ, Kim SU, Lee DS, Lee SR, Lee Y
- KMID: 2451076
- Exp Neurobiol.
- 2019 Jun;28(3):414-424.
- doi: 10.5607/en.2019.28.3.414
Mitochondria continuously fuse and divide to maintain homeostasis. An impairment in the balance between the fusion and fission processes can trigger mitochondrial dysfunction. Accumulating evidence suggests that mitochondrial dysfunction is... -
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