Exp Mol Med.
2014 Nov;46(11):e123. 10.1038/emm.2014.73.
miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
- Affiliations
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- 1Department of Biochemistry, College of Medicine, The Catholic University of Korea, Seoul, South Korea. leeek@catholic.ac.kr
- 2Department of Molecular Science and Technology, Ajou University, Suwon, South Korea.
- 3Department of Cellular and Molecular Medicine, College of Medicine, Chosun University, Gwangju, South Korea.
- 4Department of East-West Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Suwon, South Korea.
- 5Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
- 6Cancer Evolution Research Center, The Catholic University of Korea, Seoul, South Korea.
- KMID: 2155388
- DOI: http://doi.org/10.1038/emm.2014.73
Abstract
- Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial dynamics is related to the pathogenesis of several human diseases, its molecular mechanism is not fully elucidated. In this study, we demonstrate the potential role of miR-27 in the regulation of mitochondrial dynamics. Mitochondrial fission factor (MFF) mRNA is a direct target of miR-27, whose ectopic expression decreases MFF expression through binding to its 3'-untranslated region. Expression of miR-27 results in the elongation of mitochondria as well as an increased mitochondrial membrane potential and mitochondrial ATP level. Our results suggest that miR-27 is a novel regulator affecting morphological mitochondrial changes by targeting MFF.
MeSH Terms
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3' Untranslated Regions
Cell Line
Gene Expression Regulation
Humans
Membrane Potential, Mitochondrial
Membrane Proteins/*genetics
MicroRNAs/*metabolism
Mitochondria/*genetics/*metabolism
*Mitochondrial Dynamics
Mitochondrial Proteins/*genetics
*Protein Biosynthesis
RNA, Messenger/genetics/metabolism
3' Untranslated Regions
Membrane Proteins
MicroRNAs
Mitochondrial Proteins
RNA, Messenger
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