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Isoprenaline Induces Periostin Expression in Gastric Cancer

Liu GX, Xi HQ, Sun XY, Geng ZJ, Yang SW, Lu YJ, Wei B, Chen L

PURPOSE: Periostin mediates critical steps in gastric cancer and is involved in various signaling pathways. However, the roles of periostin in promoting gastric cancer metastasis are not clear. The aim...
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Concomitant inhibition of renin angiotensin system and Toll-like receptor 2 attenuates renal injury in unilateral ureteral obstructed mice

Chung S, Jeong JY, Chang YK, Choi DE, Na KR, Lim BJ, Lee KW

BACKGROUND/AIMS: There has been controversy about the role of Toll-like receptor 2 (TLR2) in renal injury following ureteric obstruction. Although inhibition of the renin angiotensin system (RAS) reduces TLR2 expression...
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Chemokine Signaling Pathway Involved in CCL2 Expression in Patients with Rheumatoid Arthritis

Zhang L, Yu M, Deng J, Lv X, Liu J, Xiao Y, Yang W, Zhang Y, Li C

PURPOSE: Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Chemokines are involved in RA pathogenesis. In this study,...
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Hypoxia Increases Epithelial Permeability in Human Nasal Epithelia

Min HJ, Kim TH, Yoon JH, Kim CH

PURPOSE: The nasal mucosa is the first site to encounter pathogens, and it forms continuous barriers to various stimuli. This barrier function is very important in the innate defense mechanism....
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Cloning, expression and functional analysis of the duck Toll-like receptor 5 (TLR5) gene

Cheng Y, Sun Y, Wang H, Shi S, Yan Y, Li J, Ding C, Sun J

Toll-like receptor 5 (TLR5) is responsible for the recognition of bacterial flagellin in vertebrates. In the present study, the first TLR5 gene in duck was cloned. The open reading frame...
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Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate Cancer

Yan C, Kim YH, Kang HW, Seo SP, Jeong P, Lee IS, Kim D, Kim JM, Choi YH, Moon SK, Yun SJ, Kim WJ

The potential use of urinary nucleic acids as diagnostic markers in prostate cancer (PCa) was evaluated. Ninety-five urine samples and 234 prostate tissue samples from patients with PCa and benign...
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Biologic Response of Degenerative Living Human Nucleus Pulposus Cells to Treatment with Cytokines

Kim SH, Kuh SU, Kim KN, Park JY, Cho KH, Chin DK, Kim KS, Cho YE

PURPOSE: To investigate the molecular responses of various genes and proteins related to disc degeneration upon treatment with cytokines that affect disc-cell proliferation and phenotype in living human intervertebral discs...
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Benzylideneacetophenone derivatives attenuate IFN-gamma-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition

Lee SH, Lim SY, Choi JH, Jung JC, Oh S, Kook KH, Choi YH

The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized...
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Identification of abnormal gene expression in bovine transgenic somatic cell nuclear transfer embryos

Cho J, Kang S, Lee BC

This study was conducted to investigate the expression of three genes related to early embryonic development in bovine transgenic cloned embryos. To accomplish this, development of bovine transgenic somatic cell...
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Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice

Huang Z, Yu M, Tong S, Jia K, Liu R, Wang H, Li S, Ning Z

Activation of the innate immune system requires recognition of pathogen-associated molecular patterns, such as NOD-like receptors. The NOD-like receptor protein 3 (NLRP3) inflammasome is involved in induction of the pro-inflammatory...
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Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma

Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM, Chung YJ

Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unknown. We...
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Quantitative expression and localization of cysteine and aspartic proteases in human abdominal aortic aneurysms

Lohoefer F, Reeps C, Lipp C, Rudelius M, Haertl F, Matevossian E, Zernecke A, Eckstein H, Pelisek J

Cysteine and aspartic proteases possess high elastolytic activity and might contribute to the degradation of the abdominal aortic aneurysm (AAA) wall. The aim of this study was to analyze, in...
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Role of histone deacetylase activity in the developing lateral line neuromast of zebrafish larvae

He Y, Mei H, Yu H, Sun S, Ni W, Li H

Histone deacetylases are involved in many biological processes and have roles in regulating cell behaviors such as cell cycle entry, cell proliferation and apoptosis. However, the effect of histone deacetylases...
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Ribosomal protein mutations in Korean patients with Diamond-Blackfan anemia

Chae H, Park J, Lee S, Kim M, Kim Y, Lee JW, Chung NG, Cho B, Jeong DC, Kim J, Kim JR, Park G

Diamond-Blackfan anemia (DBA) is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, associated physical malformations and a predisposition to cancer. DBA has been associated with mutations and deletions...
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Stanniocalcin-1 protects bovine intestinal epithelial cells from oxidative stress-induced damage

Wu LM, Guo R, Hui L, Ye YG, Xiang JM, Wan CY, Zou M, Ma R, Sun XZ, Yang SJ, Guo DZ

Chronic enteritis can produce an excess of reactive oxygen species resulting in cellular damage. Stanniocalcin-1(STC-1) reportedly possesses anti-oxidative activity, the aim of this study was to define more clearly the...
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miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor

Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK

Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial...
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A known expressed sequence tag, BM742401, is a potent lincRNA inhibiting cancer metastasis

Park SM, Park SJ, Kim HJ, Kwon OH, Kang TW, Sohn HA, Kim SK, Moo Noh S, Song KS, Jang SJ, Sung Kim Y, Kim SY

  • KMID: 2154250
  • Exp Mol Med.
  • 2013 Jul;45(7):e31.
Long intergenic non-coding RNAs (lincRNAs) have historically been ignored in cancer biology. However, thousands of lincRNAs have been identified in mammals using recently developed genomic tools, including microarray and high-throughput...
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Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform

Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS

  • KMID: 2154232
  • Exp Mol Med.
  • 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary...
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B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages

Kim MY, Kim DH, Do MS

  • KMID: 2154223
  • Exp Mol Med.
  • 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we...
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Acute UV Irradiation Increases Heparan Sulfate Proteoglycan Levels in Human Skin

Jung JY, Oh JH, Kim YK, Shin MH, Lee D, Chung JH

Glycosaminoglycans are important structural components in the skin and exist as various proteoglycan forms, except hyaluronic acid. Heparan sulfate (HS), one of the glycosaminoglycans, is composed of repeated disaccharide units,...
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