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Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy

Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS

BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated...
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The Potential Role of MicroRNA in Diabetic Cardiomyopathy

Kim JH

No abstract available.
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Mitochondrial Mechanisms in Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus...
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Established and Emerging Mechanisms of Diabetic Cardiomyopathy

Gollmer J, Zirlik A, Bugger H

Diabetes mellitus increases the risk for the development of heart failure even in the absence of coronary artery disease and hypertension, a cardiac entity termed diabetic cardiomyopathy (DC). Clinically, DC...
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Diabetic cardiomyopathy: where we are and where we are going

Lee WS, Kim J

The global burden of diabetes mellitus and its related complications are currently increasing. Diabetes mellitus affects the heart through various mechanisms including microvascular impairment, metabolic disturbance, subcellular component abnormalities, cardiac...
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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy

Brahma MK, Pepin ME, Wende AR

Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level...
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Insulin-like growth factor-1 improves diabetic cardiomyopathy through antioxidative and anti-inflammatory processes along with modulation of Akt/GSK-3β signaling in rats

Wang CY, Li XD, Hao ZH, Xu D

Diabetic cardiomyopathy (DCM), a serious complication of diabetes mellitus, is associated with changes in myocardial structure and function. This study sought to explore the ability of insulin-like growth factor-1 (IGF-1)...
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Diabetic Cardiomyopathy; Summary of 41 years

Yilmaz S, Canpolat U, Aydogdu S, Abboud HE

Patients with diabetes have an increased risk for development of cardiomyopathy, even in the absence of well known risk factors like coronary artery disease and hypertension. Diabetic cardiomyopathy was first...
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Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status

Chen J, Zhang Z, Cai L

Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen...
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Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy

Lee EH, Lee HK, Kim HW, Kim YH

  • KMID: 1600069
  • Korean J Physiol Pharmacol.
  • 2005 Aug;9(4):195-201.
High extracellular glucose concentration was reported to suppress intracellular Ca2+ clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and...
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Unchanged protein level of ryanodine receptor but reduced (3H) ryanodine binding of cardiac sarcoplasmic reticulum from diabetic cardiomyopathy rats

Lee EH, Seo YJ, Kim YH, Kim HW

  • KMID: 1607079
  • Korean J Physiol Pharmacol.
  • 2001 Oct;5(5):397-405.
The ryanodine receptor, a Ca2+ release channel of the sarcoplasmic reticulum (SR), is responsible for the rapid release of Ca2+ that activates cardiac muscle contraction. In the excitation-contraction coupling cascade, activation of SR...
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